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| 1 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 2 | Disentangling the Incentive and entrenchment effects of large Shareholdings 显示文摘 | Claessens S Djankov S FAN J Lang L H P | 2002 | Journal of Finance2002，57，6： | 1 |
| 3 | Comparison of the efficacy of lamivudine and telbivudine in the treatment of chronic hepatitis B: a systematic review显示文摘 | Zhao S Tang L Fan X | 2010 | Virol J2010，7，： | 1 |
| 4 | A study of early pregnancy factor activity in the sera of women with trophoblastic tumor显示文摘 | Fan X Yan L Jia S | 1999 | Am J Reprod Immrnol1999，41，3： | 1 |
| 5 | Output characteristics of high power double-clad fiber laser显示文摘 | LU F Y FAN Y X HU S L | 2002 | SPIE2002，4914，： | 1 |
| 6 | Supercritical-phase process for selective synthesis of heavy hydrocarbons from syngas on cobalt catalysts显示文摘 | Yan S R Fan L Fujimoto K | 1998 | Appl Catal A:Gen1998，171，7： | 1 |
| 7 | Short-term load forecasting usingcomprehensive combination based on multi-meteorologicalinformation显示文摘 | FAN S CHEN L LEE W J | 2009 | IEEE Trans on Industry Applications2009，45，4： | 1 |
| 8 | Finite Element Modeling of Single Lap Screw Connections in Steel Sheeting Under Static Shear显示文摘 | FAN L RONDAL J CESCOTTO S | 1997 | Thin-walled Structures1997，27，2： | 1 |
| 9 | Biomass and lipid production of marine microalgae using municipal wastewater and high concentration of CO2显示文摘 | Jiang L Luo S Fan X | 2011 | Applied Energy2011，88，10： | 1 |
| 10 | Physical properties of silk fibroin/ cellulose blend films regenerated from the hydrophilic ionic liquid显示文摘 | Shang S Zhu L Fan J | 2011 | Carbohydrate Polymers2011，86，2： | 1 |
| 11 | Effect of Bi203 on physical, optical and structural properties of boron silicon bismuthate glasses 显示文摘 | GAO G HU L L FAN H Y WANG G N LI K F FENG S Y FAN S J CHEN H Y | 2009 | Optical Materials2009，32，： | 1 |
| 12 | Measurement of real-time flow stnlct- ms in gas-liquid and gas-liquid-solid flow systems using electrical capacitance tomography (ECT) 显示文摘 | Warsito W Fan L S | 2001 | Chemical Engineering Science2001，56，2122： | 1 |
| 13 | Fault-tree analysis by fuzzy probability 显示文摘 | TANNK A H FAN L T LAI F S | 1983 | IEEE Transactions on Reliability1983，32，5： | 1 |
| 14 | A multimodal tomography system based on ECT sensors显示文摘 | Marashdeh Q Warsito W Fan L S | 2007 | IEEE Sensors J2007，，7： | 1 |
| 15 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 16 | Nutritional composition of five cultivars of chinese jujube 显示文摘 | Li J W Fan L P Ding S D | 2007 | Food Chemistry2007，103，： | 1 |
| 17 | The Benefits and Costs of Group Affiliation : Evidence from East Asia 显示文摘 | Claessens S Fan J Lang L | 2006 | Emerging Markets Re- view2006，7，1： | 1 |
| 18 | Finite element modelling of single lap screw connections in steel sheeting under static shear 显示文摘 | Fan L Rondal J Cescotto S | 1997 | Thin-Walled Structures1997，27，2： | 1 |
| 19 | Free vibrations of tapered piles embedded partially in Winkler type foundations显示文摘 | LEE B K JEONG J S FAN L G JIN T K | 1999 | J Civil Engrg1999，3，2： | 1 |
| 20 | Nutritional composition ot- five cultivars of Chinese jujube 显示文摘 | Li J W Fan L P Ding S D | 2007 | Food Chemistry2007，103，2： | 1 |
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