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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 3 | Fludarabine induces apoptosis in chronic lymphocytic leukemia--the role of P53,Bcl-2,Bax,Mcl-1,and Bag-1 proteins显示文摘 | Faria JR Yamamoto M Faria RM | 2006 | Braz J Med Res2006，39，3： | 1 |
| 4 | Ultrasonography for the evolution of visceral fat and cardiovascular risk显示文摘 | Ribeiro-Filho FF Faria AN Kohlmann O Jr | 2001 | Hypertension2001，38，： | 1 |
| 5 | Differential effects of Apo lipoprotein A1 mimetic peptide on evolving and established atherosclerosis in Apo lipoprotein E null mice显示文摘 | Li X Chyu KY Faria Neto JR | 2004 | Circulation2004，110，12： | 1 |
| 6 | Surgical treat-ment of a giant left ventricular aneurysm - a case report显示文摘 | Schaitza GA Faria Neto JR Francisco JC | 2014 | RevBras Cir Cardiovasc *2014，29，4： | 1 |
| 7 | Surgical porcine myocar- dial infarction model through permanent coronary occlusion 显示文摘 | Munz MR Faria MA Monteiro JR | 2011 | Comp Med2011，61，5： | 1 |
| 8 | Differential effects of apolipoprotein A-I mimetic peptide on evolving and estab lished atherosclerosis in apolipoprotein E null mice显示文摘 | Li X Chyu KY Faria Neto JR | 2004 | Circulation2004，110，12： | 1 |
| 9 | Uhrasonograpby for the evaluation of visceral fat and cardiovascular risk显示文摘 | Ribeiro-Filho FF Faria AN Kohlmann O Jr | 2001 | Hypertension2001，38，： | 1 |
| 10 | Differential effects of apolipoprotein A-I-mimetic peptide on evolving and established atherosclerosis in apolipoprotein E-null mice显示文摘 | Li X Chyu KY Faria Neto JR | 2004 | Circulation2004，110，12： | 1 |
| 11 | Ultrasonog-raphy for the evaluation of visceral fat and cardiovascular risk显示文摘 | Ribeiro-Filho FF Faria AN Kohlmann O Jr | 2001 | Hypertension2001，38，3： | 1 |
| 12 | Synthesis and characterization of blue emitting ZnSe quantum dots 显示文摘 | Andrade J J Brasil Jr A G Farias P M A | 2009 | Micro- electron J2009，40，： | 1 |
| 13 | Differential effects of apolipoprotein A-I-mimetic peptide on evolving and established atherosclerosis in apolipoprotein e-Null mice显示文摘 | Chyu KY Faria Neto JR Yano J Nathwani N Ferreira C | 2004 | Circulation2004，110，12： | 1 |
| 14 | Use of statins and the incidence of type 2 diabetes mellitus 显示文摘 | Bernardi A Rocha VZ Faria - Neto JR | 2015 | Rev Assoc Med Bras2015，61，4： | 1 |
| 15 | Differential effects of apolipoprotein AⅠ-mimetic peptide on evolving and established atherosclerosis in apolipoprotein E-null mice显示文摘 | Li X Chyu KY Faria Neto JR Yano J Nathwani N Ferreira C | 2004 | Circulation2004，110，： | 1 |
| 16 | Ultrasonography for the cvalution of visceral fat and cardiovascular risk 显示文摘 | Ribeiro-Filho FF Faria AN Kohlmann O Jr | 2001 | Hypertension2001，38，： | 1 |
| 17 | Differential effects of apoli-poprotein A-I-mimetic peptide on evolving and established athero-selerosis in apolipoprotein E null mice显示文摘 | Li X Chyu KY Faria Neto JR | 2004 | Circulation2004，110，12： | 1 |
| 18 | Displacement control in tunnels excavated by the NATM 3D numerical simulations显示文摘 | DE FARIAS M M MORAES JR A H DE ASSIS A P | 2004 | Tunneling and Underground Space Technology2004，19，3： | 1 |
| 19 | A polyhedral study of the cardinality constrained knapsack problem 显示文摘 | Farias Jr de I R Nemhauser G L | 2003 | Mathematical Programming2003，96，： | 1 |
| 20 | Differential effects of apolipoprotein A-I-mimetic peptide on evolving and established atherosclerosis in apolipoprotein E-null mice 显示文摘 | LI X CHYU KY FARIA NETO JR | 2004 | Circulation2004，110，12： | 1 |
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