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| 1 | Partially covered vs uncovered sphincterotome and postendoscopic sphincterotomy bleeding显示文摘AIM: To prospectively compare partially covered vs uncovered sphincterotome use on post-endoscopic biliary sphincterotomy (ES) hemorrhage and other complications. METHODS: All patients referred for therapeutic endoscopic retrograde cholangiopancreatography (ERCP) were randomly assigned to undergo ES either with a partially covered or an uncovered sphincterotome. Both patient and technical risk factors contributing to the development of post-ES bleeding were recorded and analyzed. The characteristics of bleeding was recorded during and after ES. Other complications were also compared. RESULTS: Three-hundred and eighty-seven patients were recruited in this study; 194 patients underwent ES with a partially covered sphincterotome and 193 with conventional uncovered sphincterotome. No statistical difference was noted in the baseline characteristics and risk factors for post-ES induced hemorrhage between the 2 groups. No significant difference in the incidence and pattern of visible bleeding rates was found between the 2 groups (immediate bleeding in 24 patients with the partially covered sphincterotome vs 19 patients with the uncovered sphincterotome, P = 0.418). Delayed bleeding was observed in 2 patients with a partially covered sphincterotome and in 1 patient with an uncovered sphincterotome (P = 0.62). No statistical difference was noted in the rate of other complications. CONCLUSION: The partially covered sphincterotome was not associated with a lower frequency of bleeding. Also, there was no difference in the incidence of other significant complications between the 2 types of sphincterotome. | Panagiotis Katsinelos George Paroutoglou Jannis Kountouras Grigoris Chatzimavroudis Christos Zavos Sotiris Terzoudis Taxiarchis Katsinelos Kostas Fasoulas George Gelas George Tzovaras Ioannis Pilpilidis | 2010 | World Journal of Gastroenterology2010，16，40： | 5 |
| 2 | Improving the phenotypic expression of rice genotypes:Rethinking “intensification” for production systems and selection practices for rice breeding显示文摘Intensification in rice crop production is generally understood as requiring increased use of material inputs: water, inorganic fertilizers, and agrochemicals. However, this is not the only kind of intensification available. More productive crop phenotypes, with traits such as more resistance to biotic and abiotic stresses and shorter crop cycles, are possible through modifications in the management of rice plants, soil, water, and nutrients, reducing rather than increasing material inputs. Greater factor productivity can be achieved through the application of new knowledge and more skill, and(initially) more labor, as seen from the System of Rice Intensification(SRI), whose practices are used in various combinations by as many as 10 million farmers on about 4 million hectares in over 50 countries. The highest yields achieved with these management methods have come from hybrids and improved rice varieties, confirming the importance of making genetic improvements. However,unimproved varieties are also responsive to these changes, which induce better growth and functioning of rice root systems and more abundance, diversity, and activity of beneficial soil organisms. Some of these organisms as symbiotic endophytes can affect and enhance the expression of rice plants' genetic potential as well as their phenotypic resilience to multiple stresses, including those of climate change. SRI experience and data suggest that decades of plant breeding have been selecting for the best crop genetic endowments under suboptimal growing conditions, with crowding of plants that impedes their photosynthesis and growth, flooding of rice paddies that causes roots to degenerate and forgoes benefits derived from aerobic soil organisms, and overuse of agrochemicals that adversely affect these organisms as well as soil and human health. This review paper reports evidence from research in India and Indonesia that changes in crop and water management can improve the expression of rice plants' genetic potential, thereby creating more productive and robustphenotypes from given rice genotypes. Data indicate that increased plant density does not necessarily enhance crop yield potential, as classical breeding methods suggest. Developing cultivars that can achieve their higher productivity under a wide range of plant densities—breeding for density-neutral cultivars using alternative selection strategies—will enable more effective exploitation of available crop growth resources. Density-neutral cultivars that achieve high productivity under ample environmental growth resources can also achieve optimal productivity under limited resources, where lower densities can avert crop failure due to overcrowding. This will become more important to the extent that climatic and other factors become more adverse to crop production. Focusing more on which management practices can evoke the most productive and robust phenotypes from given genotypes is important for rice breeding and improvement programs since it is phenotypes that feed our human populations. | Norman Uphoff Vasilia Fasoula Anas Iswandi Amir Kassam Amod K.Thakur | 2015 | The Crop Journal2015，3，3： | 3 |
| 3 | Wireless capsule endoscopy in detecting small-intestinal polyps in familial adenomatous polyposis显示文摘AIM:To detect the prevalence of small bowel polyps by wireless capsule endoscopy(WCE)in patients with familial adenomatous polyposis(FAP).METHODS:We examined prospectively 14 patients with FAP to assess the location,size and number of small-intestinal polyps.Patients'age,sex,years of observation after surgery,type of surgery,duodenal polyps and colorectal cancer at surgery were analyzed.RESULTS:During WCE,polyps were detected in 9/14(64.3%)patients.Duodenal adenomatous polyps were found in nine(64.3%)patients,and jejunal and ileal polyps in seven(50%)and eight(57.1%),respectively.The Spigelman stage of duodenal polyposis was associated with the presence of jejunal and ileal polyps.Identification of the ampulla of Vater was not achieved with WCE.Importantly,the findings of WCE had no immediate impact on the further clinical management of FAP patients.No procedure-related complications were observed in the patients.CONCLUSION:WCE is a promising noninvasive new method for the detection of small-intestinal polyps.Further investigation is required to determine which phenotype of FAP is needed for surveillance with WCE. | Panagiotis Katsinelos Jannis Kountouras Grigoris Chatzimavroudis Christos Zavos Ioannis Pilpilidis Kostas Fasoulas George Paroutoglou | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 4 | Combination of diclofenac plus somatostatin in the prevention of post-ERCP pancreatitis: a randomized, double-blind, placebo-controlled trial显示文摘 | P. Katsinelos K. Fasoulas G. Paroutoglou G. Chatzimavroudis A. Beltsis S. Terzoudis T. Katsinelos E. Dimou C. Zavos A. Kaltsa J. Kountouras | 2012 | Endoscopy2012，，01： | 2 |
| 5 | Endoscopic management of occluded biliary uncovered metal stents:A multicenter experience显示文摘AIM:To compare diverse endoscopic interventions in the management of occluded uncovered self-expanding metal stents(SEMSs) that had been placed for palliative treatment of unresectable malignant biliary obstruction.METHODS:A retrospective review was undertaken in 4 tertiary endoscopic centers to determine optimal management of different types of occluded SEMSs.The technical success of performed treatment in occluded SEMSs,the patency of the stent,the need for re-intervention and the financial costs of each treatment were analyzed.RESULTS:Fifty four patients were included in the analysis;21 received Hanaro,19 Wallstent and 14 Flexus.For the relief of obstruction,a plastic stent was inserted in 24 patients,a second SEMS in 25 and mechanical cleaning was performed in 5 patients.The overall median second patency rates between second SEMSs and plastic stents did not differ(133 d for SEMSs vs 106 d for plastic stents;P = 0.856).Similarly,no difference was found between the overall survival of SEMS and plastic stent groups,and no procedure-related complications occurred.Incremental cost analysis showed that successive plastic stenting was a cost-saving strategy at least in Greece.CONCLUSION:Insertion of uncovered SEMSs or plastic stents is a safe and effective treatment for occluded uncovered SEMSs;insertion of plastic stents appears to be the most cost-effective strategy. | Panagiotis Katsinelos Athanasios Beltsis Grigoris Chatzimavroudis Dimitris Paikos George Paroutoglou Dimitris Kapetanos Sotiris Terzoudis Georgia Lazaraki Ioannis Pilpilidis Kostas Fasoulas Stefanos Atmatzidis Christos Zavos Jannis Kountouras | 2011 | World Journal of Gastroenterology2011，17，1： | 2 |
| 6 | Can capsule en- doscopy be used as a diagnostic tool in the evaluation of non- bleeding indications in daily clinical practice? A prospective study显示文摘 | Katslnelos P Tziomalos K Fasoulas K | 2011 | Med Princ Pract2011，20，4： | 1 |
| 7 | Validation and designation of quantitative trait loci for seed protein, seed oil, and seed weight from two soybean populations 显示文摘 | Fasoula V A Harris D K Boerma H R | 2004 | Crop Science2004，44，： | 1 |
| 8 | Principles underlying genetic improvement for high and stable crop yield potential显示文摘 | FASOULA VA FASOULA DA | 2002 | Field Crops Res2002，75，： | 1 |
| 9 | Endo- scopic mucosal resection of giant laterally spreading tumors with submucosal injection of hydroxyethyl starch: comparative study with normal saline solution 显示文摘 | Fasoulas K Lazaraki G Chatzimavroudis G | 2012 | Surg Laparosc Endosc Percutan Tech2012，22，3： | 1 |
| 10 | The impact of plant population density on crop yield and response to selection in maize显示文摘 | Fasoula V A Tollenaar M | 2005 | Maydica2005，50，： | 1 |
| 11 | Intra-cultivar variation for seed weight and other agronomic traits within three elite soybean cultivars显示文摘 | Vasilia A Fasoula H Roger B | 2007 | Crop Science2007，47，1： | 1 |
| 12 | Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy显示文摘Being the largest and most accessible organ of the human body,the skin could offer a window to diabetes-related complications on the microvasculature.However,skin microvasculature is typically assessed by histological analysis,which is not suited for applications to large populations or longitudinal studies.We introduce ultra-wideband rasterscan optoacoustic mesoscopy(RSOM)for precise,non-invasive assessment of diabetes-related changes in the dermal microvasculature and skin micro-anatomy,resolved with unprecedented sensitivity and detail without the need for contrast agents.Providing unique imaging contrast,we explored a possible role for RSOM as an investigational tool in diabetes healthcare and offer the first comprehensive study investigating the relationship between different diabetes complications and microvascular features in vivo.We applied RSOM to scan the pretibial area of 95 participants with diabetes mellitus and 48 age-matched volunteers without diabetes,grouped according to disease complications,and extracted six label-free optoacoustic biomarkers of human skin,including dermal microvasculature density and epidermal parameters,based on a novel image-processing pipeline.We then correlated these biomarkers to disease severity and found statistically significant effects on microvasculature parameters as a function of diabetes complications.We discuss how label-free RSOM biomarkers can lead to a quantitative assessment of the systemic effects of diabetes and its complications,complementing the qualitative assessment allowed by current clinical metrics,possibly leading to a precise scoring system that captures the gradual evolution of the disease. | Hailong He Nikolina-Alexia Fasoula Angelos Karlas Murad Omar Juan Aguirre Jessica Lutz Michael Kallmayer Martin Fuchtenbusch Hans-Henning Eckstein Annette Ziegler Vasilis Ntziachristos | 2023 | Light(Science & Applications)2023，12，11： | 1 |
| 13 | Competitive ability and plant breeding 显示文摘 | Fasoula D A Fasoula V A | 1995 | Plant Breeding Rev1995，14，： | 1 |
| 14 | Correlations between auto-allo and nil-competition and their implications in plant breeding显示文摘 | Fasoula D A | 1990 | Euphytica1990，50，： | 1 |
| 15 | Approach for combing spacecraft attitude and thermal control systems 显示文摘 | Varatharajoo R Kahle R Fasoulas S | 2003 | Journal of Spacecraft and Rocket2003，40，5： | 1 |
| 16 | Honeycomb selection design 显示文摘 | Fasoulas A C Fasoula V A | 1995 | Plant Breeding Rev1995，13，： | 1 |
| 17 | Validation and designation of quantitative trait loci for seed protein,seed oil and seed weight from two soybean populations显示文摘 | Fasoula V A Harris D K Boerma H R | 2004 | Crop Science2004，44，4： | 1 |
| 18 | A diagnostic yield and clini- cal impact of wireless capsule endoscopy in patients with chronic abdominal pain with or without diarrhea: a Greek multicenter study 显示文摘 | Katsinelos P Fasoulas K Beltsis | 2011 | Eur InternMed2011，22，5： | 1 |
| 19 | SSR-marker analysis of the intracultivar phenotypic variation discovered within 3 soybean cultivars显示文摘 | YATES J L BOERMA H R FASOULA V A | | 0，，04： | 1 |
| 20 | Correlations between auto-,allo-and nil-competition and their implications in plant breeding显示文摘 | Fasoula D A | 1990 | Euphytica1990，，50： | 1 |
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