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| 1 | Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats显示文摘AIM:To investigate whether carnitine deficiency is a risk factor during the development of diethylnitrosamine (DENA)-induced hepatic carcinogenesis. METHODS:A total of 60 male Wistar albino rats were divided into six groups with 10 animals in each group.Rats in group 1(control group)received a single intraperitoneal(i.p.)injection of normal saline. Animals in group 2(carnitine-supplemented group) were given L-carnitine(200 mg/kg per day)in drinking water for 8 wk.Animals in group 3(carnitine-depleted group)were given D-carnitine(200 mg/kg per day)and mildronate(200 mg/kg per day)in drinking water for 8 wk.Rats in group 4(DENA group)were injected with a single dose of DENA(200 mg/kg,i.p.)and 2 wk later received a single dose of carbon tetrachloride(2 mL/kg) by gavage as 1:1 dilution in corn oil.Animals in group 5(DENA-carnitine depleted group)received the same treatment as group 3 and group 4.Rats in group 6 (DENA-carnitine supplemented group)received the same treatment as group 2 and group 4.RESULTS:Administration of DENA resulted in a significant increase in alanine transaminase(ALT), gamma-glutamyl transferase(G-GT),alkaline phosphatase(ALP),total bilirubin,thiobarbituric acid reactive substances(TBARS)and total nitrate/ nitrite(NOx)and a significant decrease in reduced glutathione(GSH),glutathione peroxidase(GSHPx), catalase(CAT)and total carnitine content in liver tissues.In the carnitine-depleted rat model,DENA induced a dramatic increase in serum ALT,G-GT,ALP and total bilirubin,as well as a progressive reduction in total carnitine content in liver tissues.Interestingly, L-carnitine supplementation resulted in a complete reversal of the increase in liver enzymes,TBARS and NOx,and a decrease in total carnitine,GSH,GSHPx, and CAT induced by DENA,compared with the control values.Histopathological examination of liver tissues confirmed the biochemical data,where L-carnitine prevented DENA-induced hepatic carcinogenesis while D-carnitine-mildronate aggravated DENA-induced hepatic damage. CONCLUSION:Data from this study suggest for the first time that:(1)carnitine deficiency is a risk factor and should be viewed as a mechanism in DENA- induced hepatic carcinogenesis;(2)oxidative stress plays an important role but is not the only cause of DENA-induced hepatic carcinogenesis;and(3) long-term L-carnitine supplementation prevents the development of DENA-induced liver cancer. | Salim S Al-Rejaie Abdulaziz M Aleisa Abdulaziz A Al-Yahya Saleh A Bakheet Abdulmalik Alsheikh Amal G Fatani Othman A Al-Shabanah Mohamed M Sayed-Ahmed | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 2 | Transverse diameter of the lumbar spinal canal in normal adult Saudis显示文摘 | Amonoo-Kuofi HS Patel PJ Fatani JA | 1990 | Acta Anat1990，137，2： | 1 |
| 3 | Biomarkers of oxidative stress in acute and chronic bronchial asthma 显示文摘 | Fatani SH | 2014 | J Asthma2014，51，6： | 1 |
| 4 | Transverse diameter of the lumbar spinal canal in normal adult Saudis 显示文摘 | Amonoo-Kuofi HS Patel PJ Fatani JA | 1990 | Acta Anat1990，137，： | 1 |
| 5 | Role ofchlamydia pneumoniae,helicobacter pylori and cytomegalovirusin coronary artery disease 显示文摘 | Al - Ghamdi A Jiman - Fatani AA El - Banna H | 2011 | Pak J Pharm Sci2011，24，2： | 1 |
| 6 | Oral colon targeted delivery systems for treatment of inflammatory bowel diseases: Synthesis, in vitro and in vivo assessment 显示文摘 | Amal H El-Kamel Alaa A M Abdel-Aziz Amal J Fatani | 2008 | Int J Pharm2008，358，12： | 1 |
| 7 | MicroRNA profiling of salivary adenoid cystic carcinoma: association of miR-17-92 upregnlation with poor outcome 显示文摘 | Mitani Y Roberts DB Fatani H | 2013 | PLoS One2013，8，66： | 1 |
| 8 | The effects of physiological and pharmacological weight loss on adiponeetin and leptin mRNA levels in the rat epididymal adipose tissue 显示文摘 | Naderali EK Fatani S Telles M | 2008 | Eur J Pharmaeol2008，579，13： | 1 |
| 9 | The effects of diet-induced obesity on hepatocyte insulin signaling pathways and induction of non- alcoholic liver damage显示文摘 | Fatani S Itua I Clark P | 2011 | Int J Gen Med2011，4，： | 1 |
| 10 | Role of chlamydia pneumoniae, Helicobacter pylori and cytomegalovirus in coronary artery disease 显示文摘 | AI - Ghamdi A Jiman - Fatani AA E1 - Banna H | 2011 | Pakistan Journal of Plaarmaceutical Sciences2011，24，2： | 1 |
| 11 | Biomarkers of oxidative stress in acute andchronic bronchial asthma显示文摘 | Fatani SH | 2014 | J Asthma2014，51，6： | 1 |
| 12 | Carnitinedeficiency aggravates cyclophosphamide-induced cardiotoxicity inrats显示文摘 | FATANI AG DARWEESH AQ RIZWAN L | 2010 | Chemotherapy2010，56，1： | 1 |
| 13 | Trends in antibiotic sus- ceptibility patterns and epidemiology of MRSA isolates from several hospitals in Riyadh, Saudi Arabia显示文摘 | Baddour MM Abuelkheir MM Fatani AJ | 2006 | Ann Clin Microbiol Antimi- crob2006，5，： | 1 |
| 14 | Eruptive xanthomas with Koebner phenomenon,type 1 diabetes mellitus,hypertriglyceridaemia and hypertension in a 41-year-old man显示文摘 | Wani AM Hussain WM Fatani MI | | 0，，： | 1 |
| 15 | Protective effect of red grapeseeds proanthocyanidins against induction of diabetes by alloxan in rats显示文摘 | El-Alfy AT Ahmed AA Fatani AJ | 2005 | Pharmacol Res2005，52，3： | 1 |
| 16 | Protective effect of red grape seeds proanthocyanidins against induction of diabetes by alloxan in rats显示文摘 | Abir T. El-Alfy Amany A.E. Ahmed Amal J. Fatani | 2005 | Pharmacological Research2005，，： | 1 |
| 17 | Oral co-lon targeted delivery systems for treatment of inflammatory boweldiseases : Synthesis, in vitro and in vivo assessment 显示文摘 | El -KAMEL AH ABDEL-AZIZ AA FATANI AJ | 2008 | Int JPharm2008，358，12： | 1 |
| 18 | Eruptive xanthomas with Koehner phenomenon, type 1 diabetes mellitus, hypertrig lyceridaenia and hypertension in a 41 year old man显示文摘 | Wani AM Hussain WM Fatani MI | 2009 | BMJ Case Rep2009，10，： | 1 |
| 19 | Effects of diet-induced obe?sity on protein expression in insulin signaling pathways of skeletal muscle in male Wistar rats显示文摘 | Fatani S Abubakari AR Itua I | 2012 | IntJ Gen Med2012，5，： | 1 |
| 20 | A fat-enriched, glucose-enriched diet markedly attenuates adiponectin mRNA levels in rat epididymal adipose tissue 显示文摘 | Naderali EK Estadella D Rocha M Pickavance LC Fatani S Denis RG etal | 2003 | Clin Sci2003，105，4： | 1 |
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