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| 1 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 2 | Combination treatment with chondroitinase ABC in spinal cord injury—breaking the barrier显示文摘After spinal cord injury (SCi), re-establishing functional circuitry in the damaged central nervous system (CNS) faces multiple challenges including lost tissue volume, insufficient intrinsic growth capacity of adult neurons, and the inhibitory environment in the damaged CNS. Several treatment strategies have been developed over the past three decades, but successful restoration of sensory and motor functions will probably require a combination of approaches to address different aspects of the problem. Degradation of the chondroitin sulfate proteoglycans with the chondroitinase ABC (ChABC) enzyme removes a regeneration barrier from the glial scar and increases plasticity in the CNS by removing perineuronal nets. its mechanism of action does not clash or overlap with most of the other treatment strategies, making ChABC an attractive candidate as a combinational partner with other methods. in this article, we review studies in rat SCi models using ChABC combined with other treatments including cell implantation, growth factors, myelin-inhibitory molecule blockers, and ion channel expression. We discuss possible ways to optimize treatment protocols for future combinational studies. To date, combinational therapies with ChABC have shown synergistic effects with several other strategies in enhancing functional recovery after SCi. These combinatorial approaches can now be developed for clinical application. | Rong-Rong Zhao James W Fawcett | 2013 | Neuroscience Bulletin2013，29，4： | 10 |
| 3 | Determination of repaglinide in human plasma by high-performance liquid chromatography–tandem mass spectrometry显示文摘A rapid and sensitive method based on high-performance liquid chromatography–tandem mass spectrometry(LC–MS/MS)has been developed for the determination of repaglinide in human plasma.The analyte and internal standard(I.S.),diazepam,were extracted from plasma(25 mL)by liquid–liquid extraction with diethyl ether–dichloromethane(60:40,v/v)and separated on a XDB-C_(18) column using acetonitrile–ammonium acetate buffer(pH 6.8,0.01 mol/L)as mobile phase.The retention times of repaglinide and I.S.were 1.95 and 2.35 min,respectively.Detection was carried out using API 4000 mass spectrometer with an ESI interface operating in the multiple reaction monitoring(MRM)mode.The assay was linear over the concentration range 0.050–50 ng/mL with a limit of detection(LOD)of 0.010 ng/mL.Intra-and inter-day precisions(as relative standard deviation,R.S.D.)were ≤5.07%and ≤11.2%,respectively,and accuracy(as relative error,R.E.)was from-0.593%to -1.26%.The assay was successfully applied to a pharmacokinetic study involving a single oral administration of a tablet containing 2 mg repaglinide to each of 10 healthy volunteers. | Jie Zhang Feng Gao Xin Guan Yan-tong Sun Jing-kai Gu J.Paul Fawcett | 2011 | Acta Pharmaceutica Sinica B2011，1，1： | 7 |
| 4 | 肝移植治疗原发性胆汁性肝硬化的疗效分析显示文摘目的 观察原发性胆汁性肝硬化(PBC)患者和移植肝的实际生存时间,肝移植后死亡的原因及肝移植后的复发率。 方法 根据QLTS的数据库中的随访资料,回顾性分析52例共接受54次肝移植的PBC患者。52例PBC肝移植患者中,平均年龄(5 3.2±6.7)岁,平均随访时间是(5 5.4±11.3)个月。分析术前的临床特征、移植后生存情况和死亡原因,采用欧洲模式计算未接受肝移植患者和接受肝移植的患者的生存率。 结果 PBC肝移植患者的1、5、1 0年的实际生存率分别为8 8.4%、80.1%和76.9%,未接受肝移植患者实际生存率分别为80.9%、6 5.4%和19.8%。PBC患者移植后的生存率比未接受肝移植的患者(欧洲模型)预期生存率高。有6例患者经肝活检后证实PBC复发,平均复发时间(34.1±10.2)个月。肝移植术后死亡的原因是多器官功能衰竭、腹腔内出血、肾功能衰竭、败血症及心血管疾病。 结论 肝移植可提高P B C患者的生存率,延长其生存时间。 | 许崇恩 Stephen V.Lynch Glenda A.Balderson Jonathan Fawcett Russell W Strong Shinn Yeong | 2004 | 中华肝脏病杂志2004，12，9： | 6 |
| 5 | Covariation between personalities and individual differences in coping with stress:Converging evidence and hypotheses显示文摘In the past decade there has been a profusion of studies highlighting covariation between individual differences instress physiology and behavioural profiles, here called personalities. Such individual differences in ways of coping with stress arerelevant both in biomedicine, since different personalities may experience a different stress and disease vulnerability, and in behaviouralecology, since their adaptive value and evolutionary maintenance are the subject of debate. However, the precise way inwhich individual stress differences and personalities are linked is unclear. Here we provide an updated overview of this covariationacross different species and taxa, consider its functional significance and present working hypotheses for how behaviouraland physiological responses to stress might be causally linked, affecting life-history traits such as dispersal and | Claudio CARERE Doretta CARAMASCHI Tim W. FAWCETT | 2010 | Current Zoology2010，56，6： | 4 |
| 6 | Ampullary cancer of intestinal origin and duodenal cancer-A logical clinical and therapeutic subgroup in periampullary cancer显示文摘Periampullary cancers include pancreatic, ampullary, biliary and duodenal cancers. At presentation, the majority of periampullary tumours have grown to involve the pancreas, bile duct, ampulla and duodenum. This can result in difficulty in defining the primary site of origin in all but the smallest tumors due to anatomical proximity and architectural distortion. This has led to variation in the reported proportions of resected periampullary cancers. Pancreatic cancer is the most common cancer resected with a pancreaticoduodenectomy followed by ampullary(16%-50%), bile duct(5%-39%), and duodenal cancer(3%-17%). Patients with resected duodenal and ampullary cancers have a better reported median survival(29-47 mo and 22-54 mo) compared to pancreatic cancer(13-19 mo). The poorer survival with pancreatic cancer relates to differences in tumour characteristics such as a higher incidence of nodal, neural and vascular invasion. While small ampullary cancers can present early with biliary obstruction, pancreatic cancers need to reach a certain size before biliary obstruction ensues. This larger size at presentation contributes to a higher incidence of resection margin involvement in pancreatic cancer. Ampullary cancers can be subdivided into intestinal or pancreatobiliary subtype cancers with histomolecular staining. This avoids relying on histomorphology alone, as even some poorly differentiated cancers preserve the histomolecular profile of their mucosa of origin. Histomolecular profiling is superior to anatomic location in prognosticating survival. Ampullary cancers of intestinal subtype and duodenal cancers are similar in their intestinal origin and form a logical clinical and therapeutic subgroup of periampullary cancers. They respond to 5-FU based chemotherapeutic regimens such as capecitabine-oxaliplatin. Unlike pancreatic cancers, KRAS mutation occurs in only approximately a third of ampullary and duodenal cancers. Future clinical trials should group ampullary cancers of intestinal origin and duodenal cancers together given their similarities and their response to fluoropyrimidine therapy in combination with oxaliplatin. The addition of anti-epidermal growth factor receptor therapy in this group warrants study. | Manju D Chandrasegaram Anthony J Gill Jas Samra Tim Price John Chen Jonathan Fawcett Neil D Merrett | 2017 | World Journal of Gastrointestinal Oncology2017，9，10： | 4 |
| 7 | Separation and simultaneous quantitation of PGF2α and its epimer 8-iso-PGF2α using modifier-assisted differential mobility spectrometry tandem mass spectrometry显示文摘Because many therapeutic agents are contaminated by epimeric impurities or form epimers as a result of metabolism, analytical tools capable of determining epimers are increasingly in demand. This article is a proof-of-principle report of a novel DMS–MS/MS method to separate and simultaneously quantify epimers, taking PGF2α and its 8-epimer, 8-iso-PGF2α, as an example. Good accuracy and precision were achieved in the range of 10–500 ng/m L with a run time of only 1.5 min. Isopropanol as organic modifier facilitated a good combination of sensitivity and separation. The method is the first example of the quantitation of epimers without chromatographic separation. | Chunsu Liang Hui Sun Xiangjun Meng Lei Yina J.Paul Fawcett Huaidong Yu Ting Liu Jingkai Gu | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 3 |
| 8 | A 10-year study of outcome following hepatic resection for colorectal liver metastases – The effect of evaluation in a multidisciplinary team setting显示文摘 | J.T. Lordan N.D. Karanjia N. Quiney W.J. Fawcett T.R. Worthington | 2008 | European Journal of Surgical Oncology2008，，3： | 2 |
| 9 | Quantitation of bivalirudin,a novel anticoagulant peptide,in human plasma by LC-MS/MS:Method development,validation and application to pharmacokinetics显示文摘A rapid and sensitive method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the determination of a novel anticoagulant peptide bivalirudin in human plasma has been developed and validated. Plasma samples were precipitated protein with acetonitrile and re-extracted with dichloromethane, after which the analyte and triptorelin as an internal standard (IS) were separated on a 300SB-C18 column (150 mm 4.6 mm i.d., 5 mm particle size) using 0.1% formic acid:methanol (45:55, v/v) as mobile phase. The triple-quadrupole mass spectrometer, equipped with electrospray ionization (ESI) interface, was operated in the positive ion mode, and the multiple-reaction monitoring (MRM) transitions of bivalirudin and IS were at m/z 1091.0-650.4 and m/z656.5-249.3, respectively. The lower limit of quantification (LLOQ) was 1 ng/mL for 100 mL plasma sample and the assay was linear over the concentration range 1-1000 ng/mL. The accuracy was within a range from 0.4% to 0.5% in terms of relative error (RE) and the intra- and inter-day precisions in terms of relative standard deviation (RSD) were r2.92 and r3.36, respectively. The method was successfully applied to a pharmacokinetic study involving intravenous administration of bivalirudin (0.5 mg/kg) to Chinese volunteers. | Xiao-Jiao Li Yan-Tong Sun Lei Yin Xue-Ju Zhang Yan Yang J.Paul Fawcett Yi-Min Cui Jing-Kai Gu | 2013 | Journal of Pharmaceutical Analysis2013，3，1： | 2 |
| 10 | Evolution of a flexible rule for foraging that copes with environmental variation显示文摘 | Andrew D. HIGGINSON Tim W. FAWCETT Alasdair I. HOUSTON | 2015 | Current Zoology2015，61，2： | 2 |
| 11 | Protein target discovery of drug and its reactive intermediate metabolite by using proteomic strategy显示文摘Identifying protein targets of bioactive compounds is an effective approach to discover unknown protein functions,identify molecular mechanisms of drug action,and obtain information for optimization of lead compounds.At the same time,metabolic activation of a drug can lead to cytotoxicities.Therefore,it is very important to systemically characterize the drug and its reactive intermediate.Mass spectrometry-based proteomic approach has emerged as the most efficient to study protein functions and modifications.This review will discuss method development for the drug target discovery and the application in different fields including the drug toxicity mechanism caused by reactive metabolites. | Lianghai Hu John Paul Fawcett Jingkai Gu | 2012 | Acta Pharmaceutica Sinica B2012，2，2： | 2 |
| 12 | A comparison of right and extended right hepatectomy with all other hepatic resections for colorectal liver metastases: A ten-year study显示文摘 | N.D. Karanjia J.T. Lordan N. Quiney W.J. Fawcett T.R. Worthington J. Remington | 2007 | European Journal of Surgical Oncology2007，，1： | 2 |
| 13 | Tracking and traceability in the meat processing industry: a solution显示文摘 | A. Mousavi M. Sarhadi A. Lenk S. Fawcett | 2002 | British Food Journal2002，，1： | 2 |
| 14 | Normal human tissues,in addition to some tumors, express multiple different CD44 isoforms 显示文摘 | Fox SB Fawcett J Jackson DG | 1994 | Cancer Res1994，54，16： | 1 |
| 15 | Contribution of reactive oxygen species and caspase-3 to apoptosis and attenuated ICAM-1 expression by paclitaxel-treated MDA- MB-435 breast carcinoma cells显示文摘 | Fawcett H Mader JS Robichaud M | 2005 | Int J Oncol2005，27，6： | 1 |
| 16 | Effects ofchronic hemodialysis on thyroid function in chronicrenal failure 显示文摘 | Silverberg DS Ulan RA Fawcett DM | 1973 | Can Med Assoc J1973，109，： | 1 |
| 17 | Migration psychology: new behavioral models 显示文摘 | James T Fawcett | 1985 | Population & Environment1985，8，12： | 1 |
| 18 | A Dual-Channel Fiber Optic Displacement Probe for Structural Power Flow Measurements显示文摘 | Fawcett S C Keltie R F | 1989 | Sensors and Actuators1989，19，4： | 1 |
| 19 | Common variants inWFS1 confer risk of type 2 diabetes显示文摘 | Sandhu MS Weedon MN Fawcett KA | 2007 | Nat Genet2007，39，8： | 1 |
| 20 | Non-invasive intrana- sal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cere- bral artery occlusion显示文摘 | Liu XF Fawcett JR Thorne RG | 2001 | Neurosci Lett2001，308，2： | 1 |
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