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您的检索式：作者名="Faxing Zou"
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| 1 | Cellulose fibers-reinforced self-expanding porous composite with multiple hemostatic efficacy and shape adaptability for uncontrollable massive hemorrhage treatment显示文摘Uncontrollable hemorrhage leads to high mortality and thus effective bleeding control becomes increasingly important in the military field and civilian trauma arena.However,current hemostats not only present limitation when treating major bleeding,but also have various side effects.Here we report a self-expanding porous composites(CMCP)based on novel carboxymethyl cellulose(CMC)fibers and acetalized polyvinyl alcohol(PVA)for lethal hemorrhage control.The CMC fibers with uniform fibrous structure,high liquid absorption and procoagulant ability,are evenly interspersed inside the composite matrix.The obtained composites possess unique fiber-porous network,excellent absorption capacity,fast liquid-triggered self-expanding ability and robust fatigue resistance,and their physicochemical performance can be fine-tuned through varying the CMC content.In vitro tests show that the porous composite exhibits strong blood clotting ability,high adhesion to blood cells and protein,and the ability to activate platelet and the coagulation system.In vivo hemostatic evaluation further confirms that the CMCP presents high hemostatic efficacy and multiple hemostatic effects in swine femoral artery major hemorrhage model.Additionally,the CMCP will not fall off from the injury site,and is also easy to surgically remove from the wound cavity after the hemostasis.Importantly,results of CT tomography and 3D reconstruction indicate that CMCP can achieve shape adaptation to the surrounding tissues and the wound cavities with different depths and shapes,to accelerate hemostasis while protecting wound tissue and preventing infection. | Yansen Wang Yifan Zhao Longxue Qiao Faxing Zou Yajie Xie Yudong Zheng Yong Chao Ying Yang Wei He Siming Yang | 2021 | Bioactive Materials2021，6，7： | 6 |
| 2 | A novel bioactive polyurethane with controlled degradation and L-Arg release used as strong adhesive tissue patch for hemostasis and promoting wound healing显示文摘Effective strategy of hemostasis and promoting angiogenesis are becoming increasingly urgent in modern medicine due to millions of deaths caused by tissue damage and inflammation. The tissue adhesive has been favored as an optimistic and efficient path to stop bleeding, while, current adhesive presents limitations on wound care or potential degradation safety in clinical practice. Therefore, it is of great clinical significance to construct multifunctional wound adhesive to address the issues. Based on pro-angiogenic property of L-Arginine (L-Arg), in this study, the novel tissue adhesive (G-DLPUs) constructed by L-Arg-based degradable polyurethane (DLPU) and GelMA were prepared for wound care. After systematic characterization, we found that the G-DLPUs were endowed with excellent capability in shape-adaptive adhesion. Moreover, the L-Arg released and the generation of NO during degradation were verified which would enhance wound healing. Following the in vivo biocompatibility was verified, the hemostatic effect of the damaged organ was tested using a rat liver hemor-rhage model, from which reveals that the G-DLPUs can reduce liver bleeding by nearly 75% and no obvious inflammatory cells observed around the tissue. Moreover, the wound care effect was confirmed in a mouse full-thickness skin defect model, showing that the hydrogel adhesive significantly improves the thickness of newly formed dermis and enhance vascularization (CD31 staining). In summary, the G-DLPUs are promising candidate to act as multifunctional wound care adhesive for both damaged organ and trauma. | Faxing Zou Yansen Wang Yudong Zheng Yajie Xie Hua Zhang Jishan Chen M.Irfan Hussain Haoye Meng Jiang Peng | 2022 | Bioactive Materials2022，7，11： | 2 |
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