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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Loss of flow induces leukocyte - mediated MMP/TIMP imbalance in dynamic in vitro blood - brain barrier model : role of pro - inflammatory cytokines显示文摘 | Krizanac - Bengez L Hossain M Fazio V | 2006 | Am J Physiol Cell Physiol2006，291，4： | 1 |
| 3 | A microsecond-pulse length,frequency-stabilized virtual-cathode oscillator using a resonant cavity显示文摘 | Fazio M V Freeman B L Hoeberlin R L | 1992 | IEEE Trans on Plasma Sci1992，20，3： | 1 |
| 4 | Immunologic functions afterlaparoscopic cholecystectomy 显示文摘 | Puglisi F De Fazio M Capuano P | 2001 | Chir Ital2001，53，5： | 1 |
| 5 | Estimating free - flow speed from posted speed limit signs显示文摘 | I)eardoff M D Wiesner B N Fazio J | 2011 | Procedia- Social and Behavioral Sciences2011，104，： | 1 |
| 6 | Interaction of carbamaz-epine-10,11-epoxide,an active metabolite of carbamazepine,with valproate:a pharmacokinetic study显示文摘 | Pisani F Caputo M Fazio A | | 0，，03： | 1 |
| 7 | Implicit measures in social cogn ition research: their meaning and use 显示文摘 | FAZIO R H OLSON M A | | Annual Review of Psychology 200 30，54，： | 1 |
| 8 | Detection of geometric phases in superconducting nano-circuits显示文摘 | FALCI G FAZIO R PALMA G M | 2000 | Nature2000，407，： | 1 |
| 9 | Hepatocellular carcinoma in Italian patients with cirrhosis显示文摘 | Colombo M de Franchis R Del Ninno E Sangiovanni A De Fazio C Tommasini M | | New England Journal of Medicine0，，： | 1 |
| 10 | Uhracompact pulsed power显示文摘 | Fazio M V Kirbie H C | 2004 | Proceedings of the IEEE Pulsed Power: Technology and Applications2004，92，7： | 1 |
| 11 | A microsecond-pulse length, frequency-stabilized virtual-cathode oscillator using a resonant cavity显示文摘 | Fazio M V Freeman B L Hoeberlin R | 1992 | IEEE1992，20，3： | 1 |
| 12 | Loss of flow induces leukocyte-mediated MMP/TIMP imbalance in dynamic in vitro blood brain barrier model role of pro-inftamrnatotry eytokines 显示文摘 | Krizanac-Bengez L Hossain M Fazio V | 2006 | Am J Physiol Cell Physio12006，291，4： | 1 |
| 13 | Remodelling of sensorimotor maps in paraplegia a functional magnetic resonance imaging study after a surgical nerve transfer 显示文摘 | Perani d Brunelli GA Tettamanti M Scifo P Tecchio F Rossini PM Fazio F | 2001 | Neurosci Lett2001，303，1： | 1 |
| 14 | Development and characterization of PCR markers in cucumber显示文摘 | FAZIO G STAUB J E CHUNG S M | 2002 | Journal of the American Soci- ety for Horticulture Science2002，127，4： | 1 |
| 15 | A 500 MW, 1 μs pulse length high current relative klystron显示文摘 | Fazio M V Haynes W B Carlsten B E | 1994 | IEEE1994，22，5： | 1 |
| 16 | Peripheral markers of blood-brain barrier damage显示文摘 | Marchi N Cavaglia M Fazio V | 2004 | Clin Chim Acta2004，342，12： | 1 |
| 17 | Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation 显示文摘 | LINTON M E ATKINSON J B FAZIO S | 1995 | Science1995，267，： | 1 |
| 18 | A randomized multicenter trial to compare long-term functional outcome,quality of life,and complications of surgical procedures for low rectal cancers显示文摘 | Fazio VW Zutshi M Remzi FH | 2007 | Ann Surg2007，246，3： | 1 |
| 19 | Current perspectives on statins显示文摘 | MARON D J FAZIO S LINTON M F | 2000 | Circulation2000，101，2： | 1 |
| 20 | Dynamic performance evaluation of sensorless permanent magnet synchronous motor drives with reduced current sensors显示文摘 | CARPANETO M FAZIO P MARCHESONI M | 2012 | IEEE Transctions on Industry2012，59，12： | 1 |
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