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459篇 您的检索式:作者名="Volinia S"
    题名 作者 年代 出处 被引量
1一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas.Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P 2014中华神经外科疾病研究杂志2014,13,5:6
2A microRNA expression signature of human solid tumors defines cancer gene targets显示文摘Volinia S Calin GA Liu CG 0,,:2
3Evidence of geneticunderexpression in chorionic villi samples of euploid fetuseswith increased nuchal translucency at 10-11 weeks’gestation显示文摘Farina A Volinia S Arcelli D Prenat Diagn0,26,2:1
4Relation between microRNA expression and progression and prognosis of gastric cancer: a mi- croRNA expression analysis显示文摘Ueda T Volinia S Okumura H 2010Lancet Oncol2010,11,2:1
5The structural ba- sis for 14-3-3 : phosphopeptide binding specificity 显示文摘Yaffe M B Rittinger K Volinia S 1997Cell1997,91,7:1
6A microRNA expression signature of human solid tumors defines cancer gene targets显示文摘Volinia S Calin GA Liu CG 0,,:1
7A microRNA expression signature of human solid tumors defines cancer gene targets显示文摘Volinia S Calin GA Liu CG 2006Proc Natl Acad Sci USA2006,103,7:1
8A microRNA ex- pression signature of human solid tumors defines cancer targets显示文摘Volinia S Calin GA Liu CG 2006Proc Natl Acad Sci USA2006,103,7:1
9MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia显示文摘GARZON R VOLINIA S LIU C G 0,,06:1
10A microRNA expression sig- nature of human solid tumors defines cancer gene targets 显示文摘Volinia S Calin GA Liu CG 2006Proc Natl Acad Sci U S A2006,103,7:1
11A microRNA expression signature of human solid tumors defines cancer gene targets显示文摘VOLINIA S CALIN GA LIU CG 0,,:1
12Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer显示文摘Zhang L Volinia S Bonome T Calin GA Greshock J Yang N 0,,:1
13Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer显示文摘Zhang L Volinia S Bonome T 2008Proc Natl Acad Sci U S A2008,105,19:1
14A microRNA expression signature of human solid tumors defines cancer gene targets显示文摘Volinia S Calin GA Liu CG 2006Proc Natl Acad Sci U S A2006,103,7:1
15Relation between microRNAexpression and progression and prognosis of gastric cancer : ami-croRNA expression analysis显示文摘Ueda T Volinia S Okumura H 2010Lancet Oncol2010,11,2:1
16Relation between microRNA expression and progression and prognosis of gastric cancer:a microRNA expression analysis显示文摘Ueda T Volinia S Okumura H 2010Lancet Oncol2010,11,2:1
17MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukaemia显示文摘Garzon R Volinia S Liu C G 2008Blood2008,111,6:1
18A microRNA expression signature of human solid tumors defines cancer gene targets显示文摘Volinia S Calin GA Liu CG 2006Proc Natl Acad Sci USA2006,103,13:1
19MicroRNA expression signaturesin solid malignancies显示文摘Galasso M Sandhu SK Volinia S 2012Cancer J2012,18,3:1
20A microRNA signature for a BMP2-induced osteoblast lineage commitment program显示文摘Li Z Hassan MQ Volinia S 0,,:1
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