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| 1 | Trabecular Plate Loss and Deteriorating Elastic Modulus of Femoral Trabecular Bone in Intertrochanteric Hip Fractures显示文摘Osteoporotic hip fracture is associated with significant trabecular bone loss,which is typically characterized as low bone density by dual-energy X-ray absorptiometry(DXA)and altered microstructure by micro-computed tomography(μCT).Emerging morphological analysis techniques,e.g.individual trabecula segmentation(ITS),can provide additional insights into changes in plate-like and rod-like trabeculae,two major micro-structural types serving different roles in determining bone strength.Using ITS,we evaluated trabecular microstructure of intertrochanteric bone cores obtained from 23 patients undergoing hip replacement surgery for intertrochanteric fracture and 22 cadaveric controls.Micro-finite element(μFE)analyses were performed to further understand how the abnormalities seen by ITS might translate into effects on bone strength.ITS analyses revealed that,near fracture site,plate-like trabeculae were seriously depleted in fracture patients,but trabecular rod volume was maintained.Besides,decreased plate area and rod length were observed in fracture patients.Fracture patients also showed decreased elastic moduli and shear moduli of trabecular bone.These results provided evidence that in intertrochanteric hip fracture,preferential loss of plate-like trabeculae led to more rod-like microstructure and deteriorated mechanical competence adjacent to the fracture site,which increased our understanding of the biomechanical pathogenesis of hip fracture in osteoporosis. | Ji Wang Bin Zhou Ian Parkinson C.David L.Thomas John G.Clement Nick Fazzalari X.Edward Guo | 2013 | Bone Research2013，1，4： | 4 |
| 2 | Trabecular microfracture 显示文摘 | Fazzalari N L | 1993 | Calcif Tissue Int1993，53，1： | 1 |
| 3 | The ratio of messenger RNA levels of receptor activator of nuclear factor kappa B ligand to osteoprotegerin correlates with bone remodeling induces in normal human cancellous bone but not in osteoarthritis显示文摘 | Fazzalari NL Kuliwaba JS Atkins GJ | 2001 | J Bone Miner Res2001，16，6： | 1 |
| 4 | Microcomputed tomography imaging in a rat model of delayed union/ non-union fracture显示文摘 | Dickson GR Geddis C Fazzalari N | 2008 | Journal of orthopaedic research2008，26，5： | 1 |
| 5 | Bone remodeling: A review of the bone microenvironment perspective for fragility fracture ( osteo- porosis) of the hip 显示文摘 | FAZZALARI NL | 2008 | Semin Cell Dev Biol2008，2，19： | 1 |
| 6 | Micro array gene expression proling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogeni cprotein signaling显示文摘 | HOPWOOD B TSYIN A FINDLAY DM FAZZALARI NL | 2007 | Arthritis ResTher2007，5，： | 1 |
| 7 | Anti- osteoporosis therapy and fracture healing 显示文摘 | Larsson S Fazzalari NL | 2012 | Arch Orthop Trauma Surg2012，，： | 1 |
| 8 | Trabecular Microfracture显示文摘 | | 1993 | Calcif Tissue Int1993，53，1： | 1 |
| 9 | Compilation of odor and taste threshold values data显示文摘 | FAZZALARI F | 1978 | ASTM data series1978，，： | 1 |
| 10 | The ratio of messenger RNA levels of receptor activator of nuclear factor kappaB ligand to osteoprotegerin correlates with bone remodeling indices in normal human cancellous bone but not in osteoarthritis显示文摘 | Fazzalari NL Kuliwaba JS Atkins GJ | | 0，，： | 1 |
| 11 | Stability of RNA isolated from human trabecular bone at post-mortem and surgery显示文摘 | Kuliwaba JS Fazzalari NL Findlay DM | 2005 | Biochem Biophys Acta2005，1740，1： | 1 |
| 12 | Bone fracture and bone fracture repair 显示文摘 | Fazzalari N L | 2011 | Osteoporos Int2011，22，6： | 1 |
| 13 | Mechanical and pathologic consequences of induced concentric anular tears in an ovinemodel显示文摘 | Fazzalari NL Costi JJ Hearn TC | 2001 | Spine2001，26，23： | 1 |
| 14 | The elastic fibre network of the human lumbar anulus fibrosus: architecture, mechanical function and potential role in the progression of intervertebral disc degeneration 显示文摘 | Smith L J Fazzalari N L | 2009 | Eur Spine J2009，18，4： | 1 |
| 15 | The elastic fibre network of the human lumbar anulus fibrosus: architecture, mechanical function and potential role in the progression of intervertebral disc degeneration 显示文摘 | Smith LJ Fazzalari NL | 2009 | Eur Spine J2009，4，： | 1 |
| 16 | Intervertebral disc disorganisation and its relationship to age adjusted vertebral body morphometry and vertebral bone architecture 显示文摘 | Fazzalari NL Manthey B Parkinson IH | 2001 | Anat Rec2001，262，3： | 1 |
| 17 | Interrelationships Between Structural Parameters of Cancellous Bone Reveal Accelerated Structural Change at Low Bone Volume显示文摘 | Parkinson IH Fazzalari NL | 2003 | Journal of Bone and Mineral Research2003，18，： | 1 |
| 18 | Trabecular microfracture显示文摘 | Fazzalari NL | 1993 | Calcif Tissue Int1993，53，1： | 1 |
| 19 | The ratio of messenger RNA levels of receptor activator of nuclear factor kappaB ligand to osteoprotegerin correlates with bone remodeling indices in normal human cancellous bone but not in osteoarthritis显示文摘 | Fazzalari NL Kuliwaba JS Atkins GJ | 2001 | J Bone Miner Res2001，16，6： | 1 |
| 20 | Regional variations in the density and arrangement of elastic fibres in the anulus fibrosus of the human lumbar disc显示文摘 | Smith LJ Fazzalari NL | | 0，，03： | 1 |
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