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| 1 | Second-line treatment of metastatic gastric cancer:Current options and future directions显示文摘Gastric cancer remains one among the leading causes of cancer-related deaths, regardless of its decreasing incidence and newly available treatment options. Most patients present at an advanced stage and are treated with upfront systemic chemotherapy. Those patients receiving first-line therapy may initially respond to treatment, but many of them relapse over time. In such condition, second-line treatment for disease progression remains the only available option. Although there exists no standard approach in the second-line setting, several phase Ⅲ trials have shown modest survival benefit in patients receiving irinotecan, taxane and ramucirumab over the best supportive care or active agents. This review analyzes the currently available treatment regimens and future directions of research in the second-line setting for metastatic gastric cancer with the best available evidence. Additionally, the prognostic factors that influence patient survival in those receiving second-line therapy are discussed. | Dheepak Kanagavel Mikhail Fedyanin Alexey Tryakin Sergei Tjulandin | 2015 | World Journal of Gastroenterology2015，21，41： | 16 |
| 2 | A prognostic model in patients treated for metastatic gastric cancer with second-line chemo-therapy显示文摘 | Kanagavel D Pokataev IA Fedyanin MY | | 0，，09： | 1 |
| 3 | Late relapses ( > 2 years) in patients with stage I testicular germ cell tumors: predic- tive factors and survival显示文摘 | Fedyanin M Tryakin A Kanagave D | 2013 | Urol 0ncol2013，31，4： | 1 |
| 4 | A prognostic model in pa- tients treated for metastatic gastric cancer with second-line chemotherapy 显示文摘 | Kanagavel D Pokataev IA Fedyanin MY | 2010 | Ann Oncol2010，21，9： | 1 |
| 5 | Chemothera- py intensification in patients with advanced seminoma and adverse prognostic factors显示文摘 | Fedyanin M Tryakin A Bulanov A | 2015 | J Cancer Res Clin Oncol2015，141，7： | 1 |
| 6 | Phase II study of concomitant chemoradiotherapy with local hyperthermia and metronidazole for locally advanced fixed rectal cancer显示文摘 | Yu. A. Barsukov S. S. Gordeyev S. I. Tkachev M. Yu. Fedyanin A. G. Perevoshikov | 2013 | Colorectal Dis2013，，9： | 1 |
| 7 | Estimate of the formation time and other parameters of a disruption structure in open pit walls in terms of Muruntau open pit显示文摘 | Bagdasar'yan AG Fedyanin AS Shemetov PA | 2009 | Journal of Mining Science?2009，45，2： | 1 |
| 8 | Non-linear effects in quasi-one-dimensional models of condensed matter theory显示文摘 | Makhankov V G Fedyanin V K | 1984 | Physics Reports1984，104，1： | 1 |
| 9 | A prognostic model in patients treated for metastatic gastric cancer with sec- ond-line chemotherapy显示文摘 | Kanagavel D Pokataev IA Fedyanin MY | 2010 | Ann Oncol2010，21，9： | 1 |
| 10 | Estimate of the formation time and other parameters of a disruption struc- ture in openpit walls in terms of Muruntau openpit显示文摘 | Bagdasaryan A G Fedyanin A S Shemetov P A | 2009 | Journal of Mining Science2009，45，2： | 1 |
| 11 | A prognostic model in patients treated for metastatic gastric cancerr with second-line chemotherapy显示文摘 | Kanagavel D Pokataev IA Fedyanin MY | 2010 | 2010，，09： | 1 |
| 12 | Dc-electric eld-induced second-harmonic interferometry of the Si(111) SiO2 interface in Cr-SiO2-Si MOS capacitor 显示文摘 | Dolgova T V Fedyanin A A Aktsipetrov O A | 2003 | Phys Rev B2003，68，07： | 1 |
| 13 | A prognostic model in patients treated for metastatic gastric cancer with sec- ond-line chemotherapy 显示文摘 | Kanagavel D Pokataev IA Fedyanin MY | 2010 | Ann Oncol2010，21，9： | 1 |
| 14 | A prognostic model in patients treated for metastatic gastric cancer with second-line chemotherapy显示文摘 | Kanagavel D Pokataev lA Fedyanin MY | 2010 | Ann Oncol2010，21，9： | 1 |
| 15 | A prognostic model in patients treated for metastatic gastric cancer with second-line chemotherapy显示文摘 | Kanagavel D Pokataev IA Fedyanin MY | 2010 | Ann Oncol2010，21，9： | 1 |
| 16 | Soliton-like solution of the S3-equation perturbed by resonance interaction显示文摘 | Makhankov V G Fedyanin V K | 1978 | Phys Lett A1978，68，2： | 1 |
| 17 | Clinical significance of molecular subtypes of gastrointestinal tract adenocarcinoma显示文摘Adenocarcinomas of the gastrointestinal tract(esophagus,stomach,and colon)represent a heterogeneous group of diseases with distinct etiology,clinical features,treatment approaches,and prognosis.Studies are ongoing to isolate molecular genetic subtypes,perform complete biological characterization of the tumor,determine prognostic groups,and find predictive markers to the effectiveness of therapy.Separate molecular genetic classifications were created for esophageal adenocarcinoma[The Cancer Genome Atlas(TCGA)],stomach cancer(TCGA,Asian Cancer Research Group),and colon cancer(Colorectal Cancer Subtyping Consortium).In 2018,isolation of TCGA molecular genetic subtypes for adenocarcinomas of the gastrointestinal tract(esophagus,stomach,and colon)highlighted the need for further studies and clinical validation of subtyping of gastrointestinal adenocarcinomas.However,this approach has limitations.The aim of our work was to critically analyze integration of molecular genetic subtyping of gastrointestinal adenocarcinomas in clinical practice. | Ekaterina Olegovna Ignatova Evgenii Kozlov Maxim Ivanov Vladislav Mileyko Sofia Menshikova Henian Sun Mikhail Fedyanin Alexey Tryakin Ivan Stilidi | 2022 | World Journal of Gastrointestinal Oncology2022，14，3： | 0 |
| 18 | Prognostic and predictive role of immune microenvironment in colorectal cancer显示文摘Colorectal cancer(CRC)represents a molecularly heterogeneous disease and one of the most frequent causes of cancer-related death worldwide.The traditional classification of CRC is based on pathomorphological and molecular character-istics of tumor cells(mucinous,ring-cell carcinomas,etc.),analysis of mechanisms of carcinogenesis involved(chromosomal instability,microsatellite instability,CpG island methylator phenotype)and mutational statuses of commonly altered genes(KRAS,NRAS,BRAF,APC,etc.),as well as expression signatures(CMS 1-4).It is also suggested that the tumor microenvironment is a key player in tumor progression and metastasis in CRC.According to the latest data,the immune microenvironment can also be predictive of the response to immune checkpoint inhibitors.In this review,we highlight how the immune environment influences CRC prognosis and sensitivity to systemic therapy. | Olesya Kuznetsova Mikhail Fedyanin Larisa Zavalishina Larisa Moskvina Olga Kuznetsova Alexandra Lebedeva Alexey Tryakin Galina Kireeva Gleb Borshchev Sergei Tjulandin Ekaterina Ignatova | 2024 | World Journal of Gastrointestinal Oncology2024，16，3： | 0 |
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