|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Appended corrole manganese complexes:Catalysis and axial-ligand effect显示文摘A series of N-base appended corroles and their manganese complexes were synthesized and their binding constants with three different nitrogenous ligands,triethylamine,N-methylimidazole and pyridine,were evaluated by spectroscopy.Kinetic studies indicated that the presence of appended Ndonor ligands may cause a significant enhancement of the rate of oxygen atom transfers(OAT) from(oxo)manganese(V) corrole to alkene,and the stronger axial ligand binding has impact on the rate of the oxidation reaction.Turnover frequency(TOF) for the catalytic oxidation of alkenes by appended manganese corroles varies with the following ligand order:acetamido < pyridyl < imidazolyl.The influence of the external axial ligands on the catalytic epoxidation was investigated by using appended acetamido manganese corrole as catalyst,with the results revealing that N-methylimidazole gave the best enhancement on the yields of total oxidation products among the investigated nitrogenous ligands. | Nga-Chun Ng Mian HR Mahmood Chi-K.Chang Hai-Yang Liu Fei Yam Lam-Lung Yeung | 2014 | Chinese Chemical Letters2014，25，4： | 3 |
| 3 | Caudatin induces cell cycle arrest and caspase-dependent apoptosis in HepG2 cell 显示文摘 | Fei HR Chen HL Xiao T | 2012 | Mol Biol Rep2012，39，1： | 1 |
| 4 | Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carci- noma cell lines by blockade of Akt phosphorylation显示文摘 | Fei HR Chen G Wang JM | 2010 | Cytotechnology2010，62，5： | 1 |
| 5 | Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcino- ma cell lines by blockade of Akt phosphorylation 显示文摘 | Fei HR Chen G Wang JM | 2010 | Cy- totechnology2010，62，5： | 1 |
| 6 | Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carci- noma cell lines by blockade of Akt phosphorylation显示文摘 | Fei HR Chen G Wang JM | 2010 | Cytotechnology2010，62，5： | 1 |
| 7 | Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation显示文摘 | FEI HR CHEN G WANG JM | 2010 | Cytotechnology2010，62，5： | 1 |
| 8 | Hepatitis B x-interac-ting protein induces HepG2 cell proliferation through activationof the phosphatidylinositol 3-kinase/Akt pathway显示文摘 | WANG FZ FEI HR LIAN LH | 2011 | Exp BiolMed(Maywood)2011，236，1： | 1 |
| 9 | Caudatin induces cell cy-cle arrest and caspase-dependent apoptosis in HepG2 cell 显示文摘 | Fei HR Chen HL Xiao T | 2012 | Mol Biot Rep2012，39，1： | 1 |
| 10 | Caudatin inhibits car- cinomic human alveolar basal epithelial cell growth and an- giogenesis through modulating GSK3β/β-catenin pathway 显示文摘 | Fei HR Cui LY Zhang ZR | 2012 | J Cell Biochem2012，113，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员