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| 1 | Phosphate removal from domestic wastewater using thermally modified steel slag显示文摘This study was performed to investigate the removal of phosphate from domestic wastewater using a modified steel slag as the adsorbent. The adsorption effects of alkalinity, salt, water,and thermal modification were investigated. The results showed that thermal activation at 800℃ for 1 hr was the optimum operation to improve the adsorption capacity. The adsorption process of the thermally modified slag was well described by the Elovich kinetic model and the Langmuir isotherm model. The maximum adsorption capacity calculated from the Langmuir model reached 13.62 mg/g. Scanning electron microscopy indicated that the surface of the modified slag was cracked and that the texture became loose after heating. The surface area and pore volume did not change after thermal modification. In the treatment of domestic wastewater, the modified slag bed(35.5 kg) removed phosphate effectively and operated for 158 days until the effluent P rose above the limit concentration of 0.5 mg/L. The phosphate fractionation method, which is often applied in soil research, was used to analyze the phosphate adsorption behavior in the slag bed. The analysis revealed that the total contents of various Ca–P forms accounted for 81.4%–91.1%, i.e., Ca10–P 50.6%–65.1%, Ca8–P 17.8%–25.0%,and Ca2–P 4.66%–9.20%. The forms of Al–P, Fe–P, and O–P accounted for only 8.9%–18.6%. The formation of Ca10–P precipitates was considered to be the main mechanism of phosphate removal in the thermally modified slag bed. | Jian Yu Wenyan Liang Li Wang Feizhen Li Yuanlong Zou Haidong Wang | 2015 | Journal of Environmental Sciences2015，27，5： | 13 |
| 2 | Preparation and evaluation of sustained-release solid dispersions co-loading gastrodin with borneol as an oral brain-targeting enhancer显示文摘Borneol is a traditional Chinese medicine that can promote drug absorption from the gastrointestinal tract and distribution to the brain.However,stomach irritation may occur when high doses of borneol are used.In the present work,gastrodin,the main bioactive ingredient of the traditional Chinese drug“Tianma”(Rhizoma Gastrodiae)was used as a model drug to explore reasonable application of borneol.Sustained-release solid dispersions(SRSDs)for co-loading gastrodin and borneol were prepared using ethylcellulose as a sustained release matrix and hydroxy-propyl methylcellulose as a retarder.The dispersion state of drug within the SRSDs was analyzed by using scanning electron microscopy,differential scanning calorimetry,and powder X-ray diffractometry.The results indicated that both gastrodin and borneol were molecularly dispersed in an amorphous form.Assay of in vitro drug release demonstrated that the dissolution profiles of gastrodin and borneol from the SRSDs both fitted the Higuchi model.Subsequently,gastric mucosa irritation and the brain targeting of the SRSDs were evaluated.Compared with the free mixture of gastrodin and borneol,brain targeting of SRSDs was slightly weaker(brain targeting index:1.83 vs.2.09),but stomach irritation obviously reduced.Sustained-release technology can be used to reduce stomach irritation caused by borneol while preserving sufficient transport capacity for oral brain-targeting drug delivery. | Zheng Cai Xiaolu Lei Zhufen Lin Jie Zhao Feizhen Wu Zhaoxiang Yang Junxue Pu Zhongqiu Liu | 2014 | Acta Pharmaceutica Sinica B2014，4，1： | 7 |
| 3 | Ecotoxicity assessment of soil irrigated with domestic wastewater using different extractions显示文摘与对待的国内废水(地点 A ) 和未经治疗的灰色的废水(地点 B ) 灌溉的土壤的毒性被调查。土壤摘录用提取的水被准备,酸溶剂(车辆的 0.1 molid 生长,在路边的平均下午 2.5 集中在一个相对小的范围上在在 2001 和 2008 之间的采样时期期间波动。与控制在奥林匹克期间测量的暂时的交通的实现,清楚的 V 塑造了弯曲证明在路边的微粒物质和另外的气体的空气污染物质的集中随着时间的过去被识别。分别地,下午 10, 下午 2.5, 公司并且不的平均集中从 6 月在 31.2% , 46.3% , 32.3% 和 35.4% 减少了到 8 月;这被所有空气污染物质的反弹在 2008 年 12 月跟随。主要道路附近的每日的下午 10 集中在非奥林匹克时期为 61.2% of the days 超过了国家周围的空气质量标准(等级 II ) ,当时仅仅为 12.5% 在奥林匹克期间。主要道路附近的下午 2.5/ 下午 10 的吝啬的比率在 0.55 点仍然保持相对稳定( | Wenyan LIANG Lili SUI Yuan ZHAO Feizhen LI Lijun LIU Di XIE | 2015 | Frontiers of Environmental Science & Engineering2015，9，4： | 1 |
| 4 | PHD Finger Recognition of Unmodified Histone H3R2 Links UHRF1 to Regulation of Euchromatic Gene Expression显示文摘 | Eerappa Rajakumara Zhentian Wang Honghui Ma Lulu Hu Hao Chen Yan Lin Rui Guo Feizhen Wu Haitao Li Fei Lan Yujiang Geno Shi Yanhui Xu Dinshaw J. Patel Yang Shi | 2011 | Molecular Cell2011，，： | 1 |
| 5 | DNMT3A reads and connects histone H3K36me2 to DNA methylation显示文摘Dear Editor,DNA methylation at the 5-position of cytosine(5mC)is a crucial epigenetic mark in regulating biological processes including gene silencing,gene imprinting,and X chromo-some inactivation(Jaenisch and Bird,2003;Smith and Meissner,2013).Human genome encodes three DNA methyltransferases,DNMT1,DNMT3A and DNMT3B to catalyze 5mC.Although not tightly restricted,DNMT1 is thought to maintain the established pattern of 5mC throughout DNA replication,while DNMT3A and DNMT3B are largely responsible for the de novo establishment of 5mC.It has long been questioned how de novo DNA 5mC patterns are established in different genomic regions and whether histone modifications crosstalk to the process.Until recently,it was reported that through recognition of histone H3K36me3 mark,DNMT3B plays a dominant role in medi-ating DNA 5mC in the genic region undergoing active tran-scription(Baubec et al.,2015;Neri et al,2017).However,5mC occurs at both intergenic and genic regions,while H3K36me3 is largely absent in the intergenic regions,indi-cating that the intergenic 5mC may be mediated through diferent mechanisms. | Wenqi Xu Jiahui Li Bowen Rong Bin Zhao Mei Wang Ruofei Dai Qilong Chen Hang Liu Zhongkai Gu Shuxian Liu Rui Guo Hongjie Shen Feizhen Wu Fei Lan | 2020 | Protein & Cell2020，11，2： | 0 |
| 6 | Correction to:DNMT3A reads and connects histone H3K36me2 to DNA methylation显示文摘The author would like to add the below information in this correction.A similar study from Chao Lu group was published online on 5 September 2019 in Nature,entitled“The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape”(Weinberg et al.,2019).Although both studies reported the preferential recognition of H3K36me2 by DNMT3A PWWP,ours in addition uncovered a stimulation function by such interaction on the activity of DNMT3A.On the disease connections,we used a NSD2 gain-of-function model which led to the discovery of potential therapeutic implication of DNA inhibitors in the related cancers,while the other study only used NSD1 and DNMT3A loss-of-function models. | Wenqi Xu Jiahui Li Bowen Rong Bin Zhao Mei Wang Ruofei Dai Qilong Chen Hang Liu Zhongkai Gu Shuxian Liu Rui Guo Hongjie Shen Feizhen Wu Fei Lan | 2020 | Protein & Cell2020，11，3： | 0 |
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