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| 1 | Negative Feedback Regulation of Auxin Signaling by ATHB8/ACL5-BUD2 Transcription Module显示文摘 | Simona Baima Valentina Forte Marco Possenti Andres Penalosa Guido Leoni Sergio Salvi Barbara Felici Ida Ruberti Giorgio Morelli | 2014 | Molecular Plant2014，7，6： | 4 |
| 2 | Endoscopic papillary balloon dilation for diffi cult common bile duct stones:Our experience显示文摘AIM: To evaluate the eff icacy and safety of endoscopic balloon dilation(EBD) performed for common bile duct(CBD) stones.METHODS: From a computer database, we retrospectively analyzed the data relating to EBD performed in patients at the gastrointestinal unit of the Sandro Pertini Hospital of Rome(small center with low case volume) who underwent endoscopic retrograde cholangiopancreatography(ERCP) for CBD from January 1, 2010 to February 29, 2012. All patients had a proven diagnosis of CBD stones studied with echography, RMN cholangiography and, when necessary, with computed tomography of the abdomen(for example, in cases with pace-makers). Prophylactic therapies, with gabexate mesilate 24 h before the procedure and with an antibiotic(ceftriaxone 2 g) 1 h before, were administered in all patients. The duodenum was intubated with a side-viewing endoscope under deep sedation with intravenous midazolam and propofol. The patients were placed in the supine position in almost all cases. EBDof the ampulla was performed under endoscopic and f luoroscopic guidance with a balloon through the scope(Hercules, wireguided balloon, Cook Ireland Ltd. and CRE, Microvasive, Boston Scientific Co., Natick, MA, United States). RESULTS: A total of 14 patients(9 female, 5 male; mean age of 73 years; range 57-82 years) were enrolled in the study, in whom a total of 15 EBDs were performed. All patients underwent minor endoscopic sphincterotomy(ES) prior to the EBD. The size of balloon insuff lation depended on stone size and CBD dilation and this was performed until it reached 16 mm in diameter. EBD was performed under endoscopic and f luoroscopic guidance. The balloon was gradually f illed with diluted contrast agent and was maintained inf lated in position for 45 to 60 s before def lation and removal. The need for precutting the major papilla was 21.4%. In one patient(an 81-year-old), EBD was performed in a Billroth Ⅱ. Periampullary diverticula were found only in a 74-year-old female. The adverse event related to the procedures(ERCP + ES) was only an intra procedural bleeding(6.6%) that occurred after ES and was treated immediately with adrenaline sclerotherapy. No postoperative complications were reported.CONCLUSION: With the current endoscopic techniques, very few patients with choledocholithiasis require surgery. EBD is an eff icacious and safe procedure. | Maddalena Zippi Isabella De Felici Roberta Pica Giampiero Traversa Giuseppe Occhigrossi | 2013 | World Journal of Clinical Cases2013，1，1： | 4 |
| 3 | Vascular-confined multi-passage discoidal nanoconstructs for the low-dose docetaxel inhibition of triple-negative breast cancer growth显示文摘Taxane efficacy in triple negative breast cancer(TNBC)is limited by insufficient tumor accumulation and severe off-target effects.Nanomedicines offer a unique opportunity to enhance the anti-cancer potency of this drug.Here,1,000 nm×400 nm discoidal polymeric nanoconstructs(DPN)encapsulating docetaxel(DTXL)and the near infrared compound Iipid-Cy5 were engineered.DPN were obtained by filling multiple times cylindrical wells in a poly(vinyl alcohol)template with a polymer mixture comprising poly(lactic-co-glycolic acid)(PLGA)and poly(ethylene glycol)diacrylate(PEG-DA)chains together with therapeutic and imaging agents.The resulting“multi-passage”DPN exhibited higher DTXL loading,Iipid-Cy5 stability,and stiffness as compared to the conventional'single-passage'approach.Confocal microscopy confirmed that DTXL-DPN were not taken up by MDA-MB-231 cells but would rather sit next to the cell membrane and slowly release DTXL thereof.Empty DPN had no toxicity on TNBC cells,whereas DTXL-DPN presented a cytotoxic potential comparable to free DTXL(IC_(50)=2.6 nM±1.0 nM vs.7.0 nM±1.09 nM at 72 h).In orthotopic murine models,DPN accumulated in TNBC more efficiently than free-DTXL.With only 2 mg/kg DTXL,intravenously administered every 2 days for a total of 13 treatments,DTXL-DPN induced tumor regression and were associated to an overall 80%survival rate as opposed to a 30%survival rate for free-DTXL,at 120 days.All untreated mice succumbed before 90 days.Collectively,this data demonstrates that vascular confined multi-passage DPN,biomimicking the behavior of circulating platelets,can efficiently deliver chemotherapeutic molecules to malignant tissues and effectively treat orthotopic TNBC at minimal taxane doses. | Alessia Felici Daniele Di Mascolo Miguel Ferreira Simone Lauciello Luca Bono Andrea Armirotti Arunkumar Pitchaimani Anna Lisa Palange Paolo Decuzzi | 2022 | Nano Research2022，15，1： | 2 |
| 4 | Metabolic Surgery for Non-Obese Type 2 Diabetes: Incretins, Adipocytokines, and Insulin Secretion/Resistance Changes in a 1-Year Interventional Clinical Controlled Study显示文摘 | Bruno Geloneze Sylka Rodovalho Geloneze Elinton Chaim Fernanda Filgueira Hirsch Ana Claudia Felici Giselle Lambert Marcos Antonio Tambascia José Carlos Pareja | 2012 | Annals of Surgery2012，，1： | 2 |
| 5 | CD117显示文摘 | Canonico B Felici C Papa S | 2001 | J Biol Regul Homeost Agents2001，15，1： | 2 |
| 6 | Zn(II) dependence of the Aeromonas hydrophila AE036 metallo-β-lactamase activity and stability显示文摘 | Valladares M H Felici A Weber G | 1997 | Biochemistry1997，36，11： | 1 |
| 7 | Leukemia inhibitory factor sustains the survival of mouse primordial germ cells cultured on TM,feeder layers显示文摘 | MASSIMO DE FELICI SUSANNA DOLCI | 1991 | Dev Biol1991，147，： | 1 |
| 8 | Nonlinear surface EMG analysis to detect changes of motor unit conduction velocity and synchronization显示文摘 | FARINA D FATTORINI L FELICI F | 2002 | J Appl Physiol2002，93，： | 1 |
| 9 | A role for E-cadherin in mouse primordial germ cell development显示文摘 | Di Carlo A De Felici M | 2000 | Dev Biol2000，226，2： | 1 |
| 10 | Detection of hidden rhythms in surface EMG signals with a nonfinear time-seris tool显示文摘 | Filligoi G Felici F | 1999 | Med Engin Phys1999，21，67： | 1 |
| 11 | Accuracy of three electronic apex locators in anterior and posterior teeth:an ex vivo study显示文摘 | Mancini M Felici R Conte G | | 0，，05： | 1 |
| 12 | Incidence of catheter-re- lated complications in patients with central venous or hemodialy- sis catheters:a health care claims database analysis 显示文摘 | Napalkov P Felici DM Chu LK | 2013 | BMC Cardiovasc Disord2013，13，： | 1 |
| 13 | An overview of the kinetic pa- rameters of class B 13-1actamases显示文摘 | Felici A Amicosante G | 1993 | Biochem J1993，291，1： | 1 |
| 14 | Lumbar spine loading during half-squat exercises显示文摘 | CAPPOZZO A FELICI F FIGURA F | 1985 | Med Sci Sports Exe1985，，17： | 1 |
| 15 | Interference excision algorithm for frequencyhopping spread spectrum based on undecimated wavelet packet transform显示文摘 | Perez J J Rodriguez M A Felici S | 2002 | Electron Lett2002，38，16： | 1 |
| 16 | VE - cadherin is a critical, endothelial regulator of TGF-beta signalling 显示文摘 | Rudini N Felici A Giampietro C | 2008 | EMBO J2008，27，7： | 1 |
| 17 | Nonlinear surface EMG analysis to detect changes of motor unit conduction velocity and synchronization显示文摘 | Farina D Fattorini L Felici F | 2002 | J Appl Physiol2002，93，： | 1 |
| 18 | Development of a strain-specific genomic marker for monitoring a Bacillus subtilis biocontrol strain in the rhizosphere of tomato显示文摘 | Felici C Vettori L Toffanin A | 2008 | FEMS Microbiology Ecology2008，65，2： | 1 |
| 19 | Association of genetic markers within the KIT and KITLG genes with human male infertility显示文摘 | Galan J J De Felici M Buch B | 2006 | Hum Rcprod2006，21，12： | 1 |
| 20 | In vitro culture of mouse PGCs显示文摘 | De Felici M Mclaren A | 1983 | Exp Cell Res1983，144，： | 1 |
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