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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Almeida e Silva, Response surface methodology for xylital production from sugarcane bagasse hemicellulosic hydrolyzate using controlled vacuum evaporation process variables显示文摘 | Rita C L B Rodrigues Maria das Gracas A Felipe Joao B | 2003 | Process Biochemistry2003，38，： | 1 |
| 3 | Genetic Polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) Genes Associated With Pathological Characteristics of Prostate Cancer in the Ecuadorian Population显示文摘 | Andrés López-Cortés Gabriela Jaramillo-Koupermann María J. Mu?oz Alejandro Cabrera Carolina Echeverría Felipe Rosales Nicolás Vivar César Paz-y-Mi?o | 2013 | The American Journal of the Medical Sciences2013，，： | 1 |
| 4 | Pathogenicity of Beauveria bassiana (Deuteromycota: Hyphomycetes) against the cactus weevil, Metamasius spinolae ( Coleoptera: Curculionidae) under laboratory conditions 显示文摘 | Felipe T Mario Z Raquel A Juan C T David S | 2004 | Florida Entomologist2004，87，4： | 1 |
| 5 | Growth, feed efficiency and condition of common Octopus fed two formulated moist diets显示文摘 | Jesus C V Maria D H Felipe A G | 2008 | Aquaculture2008，275，： | 1 |
| 6 | Batch xylitol production by Candida guilliermondii FTI20037from sugarcane bagasse hemicellulosic hydrolyzate at controlled pH values显示文摘 | R C L B Rodrigues M G A Felipe I C Roberto | 2003 | Bioprocess Biosyst Eng2003，26，： | 1 |
| 7 | Re- sponse surface methodology for xylitol production from sugarcane bagasse hemicellulosic hydrolyzate using controlled vacuum evaporation process variables显示文摘 | Rodrigues R C L B Felipe M G A Silva J B A | 2003 | Process Biochem- istry2003，38，8： | 1 |
| 8 | Symptom and quality of life results of an international randomised phase llI study of adjuvant vaccination with Bec2/BCG in responding patients with limited disease small-cell lung cancer 显示文摘 | Bottomley A Debruyne C Felip E | 2008 | Eur J Cancer2008，44，15： | 1 |
| 9 | Bioconversion of rice straw hemicelulose hydrolysate for the production of xylitol:Effect of pH and nitrogen source显示文摘 | ROBERTO I C C SILVA S S FELIPE M G A | 1996 | Appl Biochem Biotech1996，57，1： | 1 |
| 10 | ^sup 18^F-FDG PET After 2 Cycles of ABVD Predicts Event-Free Survival in Early and Advanced Hodgkin Lymphoma显示文摘 | Cerci Juliano J Pracchia Luís F Linardi Camila C G Pitella Felipe A Delbeke Dominique Izaki Marisa Trindade Evelinda Junior José Soares Buccheri Valeria Meneghetti José C | 2010 | The Journal of Nuclear Medicine2010，，： | 1 |
| 11 | Prediction of Minimum Fluidization Velocity of Gas-solid Fluidized Beds by Pressure Fluctuation Measurements-Analysis of the Standard Deviation Methodology显示文摘 | Felipe C A S Rocha S C S | 2007 | Powder Technology2007，174，3： | 1 |
| 12 | Anaerobic codigestion of municipal, farm, and industrial organic waste: a survey of recent literature显示文摘 | Felipe A M Parviz S Hub H J C | 2006 | Water Environment Research2006，78，6： | 1 |
| 13 | Site-specific release of nascent chains from ribosomes at a sense codon显示文摘 | Doronina V A Wu C de Felipe P | | 0，，13： | 1 |
| 14 | Y-TZP ceramic processing from co- precipitated powders: a comparative study with three commercial dental ceramics 显示文摘 | Laza Dolores R R Bottino Marco C Mutlu Ozcan Luiz Felipe Valandro Regina Amaral Valter Ussui Ana H A Bressiani | 2008 | Dental Materials2008，24，1： | 1 |
| 15 | Symptom and quality of life results of an international randomised phase Ⅲ study of adjuvant vaccination with Bec2/BCG in responding patients with limited disease small-cell lung cancer显示文摘 | Boomley A Debruyne C Felip E | 2008 | Eur J Cancer2008，44，15： | 1 |
| 16 | The influence of pH,temperature and hydrolysate concentration on the removal of volatile and non-volatile compounds from sugarcane bagasse hemicellulosic hydrolysate treated with activated charcoal before or after vacuum evaporation显示文摘 | Rodrigues R C L B Felipe M G A Almeida E | 2001 | Braz J Chem Eng2001，18，： | 1 |
| 17 | Response surface methodology for xylitol production from sugarcane bagasse hemicellulosic hydrolyzate using controlled vacuum evaporation process variables 显示文摘 | Rodrigues R C L B Felipe M G A Silva J B A | 2003 | Process Biochemistry2003，38，： | 1 |
| 18 | Modulation transfer function:rigid versus foldable phakic intraocular lenses显示文摘 | Artigas JM Peris C Felipe A | | 0，，： | 1 |
| 19 | Prediction of minimum fluidization velocity of gas-solid fluidized beds by pressure uctuation meas- urements-Analysis of the standard deviation methodology 显示文摘 | Felipe C A S Rocha S C S | 2007 | Powder Technology2007，174，： | 1 |
| 20 | Impaired IL-1betainduced neutrophil accumulation in tachykinin NK1 receptor knockout mice显示文摘 | Ahluwalia A De Felipe C O'Brien J | 1998 | Br J Pharmacol1998，124，6： | 1 |
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