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| 1 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 2 | Effect of nuclear factor kappa B on intercellular adhesion molecule-1 expression and neutrophil infiltration in lung injury induced by intestinal ischemia/reperfusion in rats显示文摘瞄准:为了在肺损害的致病调查原子因素 kappa B (NF-kappaB ) 的角色,导致了旁边肠的 ischemia/reperfusion (I/R ) ,和它细胞间的粘附 molecule-1 (ICAM-1 ) 上的效果表示和嗜中性的渗入。方法:24 只 Wistar 老鼠随机被划分成控制, I/R 和吡咯烷 dithiocarbamate (PDTC ) 处理组,在各个的 n=8。I/R 组和 PDTC 治疗组织为 2 h 为 1 h 和灌注堵塞的收到的优异 mys 伤寒动脉(SMA ) 。PDTC 组在外科前与 2% 100 mg/kg PDTC 1 h 的腹膜内注射被管理。肺组织学和支气管 alveolus 肺液体(BALF ) 蛋白质是 assayed。浆液 IL-6,肺 malondialdehyde (MDA ) 和象 NF-kappaB 和 ICAM-1 的表示水平一样的 myeloperoxidase (军邮局) 被测量。结果:肺损害由肠的 I/R 导致了,被浮肿,出血和嗜中性的渗入以及由 BALF 的重要升起描绘蛋白质。比作控制组,在 I/R 显著地增加的浆液 IL-6 和肺 MDA 和军邮局的层次组织(P=0.001 ) 。NF-kappaB p65 和 ICAM-1 的强壮的积极表示被观察。在 PDTC 的管理以后,象 NF-kappaB 和 ICAM-1 一样的浆液 IL-6,肺 MDA 和军邮局的水平显著地减少了(P<0.05 ) 什么时候与 I/R 相比组。结论:NF-kappaB 的激活在肠的 I/R 直在调整嗜中性的渗入和肺 ICAM-1 表示上面导致的肺损害的致病起一个重要作用。NF-kappaB 的一个禁止者能阻止肺损害的 PDTC 通过禁止 NF-kappaB 的活动由肠的 I/R 导致了。 | Xiao-Feng Tian Ji-Hong Yao Ying-Hua Li Xue-Song Zhang Bing-An Fen Chun-Ming Yang Shu-Sen Zheng | 2006 | World Journal of Gastroenterology2006，12，3： | 28 |
| 3 | Edaravone injection reverses learning and memory deficits in a rat model of vascular dementia显示文摘Edaravone 是由禁止 endothelial 损害并且由改善施加 neuroprotective 效果的新奇免费激进的 scavenger 在大脑局部缺血的 neuronal 损坏。最近, edaravone 能减轻病理和 Alzheimers 疾病病人的认知赤字,这被报导。然而,它到脉管的痴呆(VaD ) 的关联不是清楚的。在这研究,我们部分堵塞了老鼠的双边的颈动脉动脉通过手术导致长期的服的 hypoperfusion (CCH ) , VaD 的一个著名老鼠模型。水迷宫和电压降低的禁止的测试被用来评估记忆赤字。superoxide dismutase 的活动 ?( 草皮) 并且喂奶脱氢酶(LDH ) , malondialdehyde 的内容 ?(MDA ) 并且全部的反应的氧种类被测量评估氧化压力水平。西方的污点分析被用来计算 synaptic 蛋白质表达式。有为一个 5 星期的时期的 edaravone 的治疗在有 CCH 的老鼠对空间的颠倒和害怕记忆赤字有能力,这被发现。Edaravone 显著地由增加草皮活动并且减少与 CCH 在老鼠的大脑减少了氧化应力的水平 MDA, LDH,和全部的反应的氧种类的内容。而且, edaravone 处理也与 CCH 在老鼠的海马恢复了多重 synaptic 蛋白质的层次。我们的数据提供在 VaD 支持 edaravone 的 neuroprotective 效果的直接证据。我们建议氧化应力的缓和和 synaptic 蛋白质的恢复在 neuroprotection 起重要作用。 | Xu Li Fen Lu Wei Li Lingzhi Qin Yong Yao Xuerong Ge Qingkai Yu Xinliang Liang Dongmei Zhao Xiaohong Li Jiewen Zhang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 14 |
| 4 | Incidence of Extended-Spectrum β-Lactamases and Characterization of Integrons in Extended-Spectrum β-Lactamase-producing Klebsiella pneumoniae Isolated in Shantou, China显示文摘这研究涉及生产 Klebsiella pneumoniae 的抗菌素抵抗 ofextended 光谱 beta-lactamase (ESBL ) 的水平,在 Shantou,中国,和它的机制孤立。74 非重复临床 K 孤立。生产在 2 年的一个时期上孤立的 ESBLswere 的 pneumoniae。抗菌素危险性,由 Epsilometer 测试执行了,证明大多数 isolates 是多抵抗的。聚合酶链反应证明在 beta-lactamases 的几种类型之中, SHV 是最流行的, TEM 是第二个大多数流行,并且 CTX-M 是最不流行的。69 孤立为 integrase 基因 IntI1 是积极的,但是没有 IntI2 或 IntI3 基因被发现。班 1 integrons 的可变区域被定序放大并且进一步识别了。13 个不同基因盒子和 11 不同盒子联合被检测。Dfr 和 aadA 盒子是占优势的,盒子 combinationsdfrA12, orfF 和 aadA2 最经常被发现。编码 ESBL 的基因盒子都不是 found.Integrons 是流行的并且起了一个重要作用在多在生产 ESBL K.pneumoniae 的药抵抗。 | Fen YAO Yuanshu QIAN Shuzhen CHEN Peifen WANG Yuanchun HUANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，7： | 9 |
| 5 | Tetramethylpyrazine reverses intracerebroventricular streptozotocin-induced memory deficits by inhibiting GSK-3β显示文摘大脑机能障碍,特别认知的缺陷,是在 Alzheimers 疾病(广告) 的主要复杂并发症之一,它威胁世界范围的 4680 万个人的健康。目前,认知机能障碍的致病仅仅部分被理解,并且为在广告的记忆损失的有效治疗留下逃犯。Tetramethylpyrazine (TMP ) 是从 Chuanxiong 净化的主要 bioactive 混合物之一,中国植物为神经与血管、心血管的疾病的处理使用了。TMP 的 neuroprotective 性质在一些 neurodegenerative 疾病是明显的,包括 Parkinsons 疾病。然而, TMP 是否在广告起一个 neuroprotective 作用,仍然是未知的。这里,我们报导有 TMP 的 2 星期的处理救了记忆缺陷在一个著名广告老鼠模型由 streptozotocin 的 intracerebroventricular 注射导致了的短期、长期的害怕。TMP 的管理也恢复了在注射 streptozotocin 的老鼠的空间学习和记忆保留能力。而且, TMP 禁止了 GSK-3 的活动,调停的重要 kinase 在糖尿病 mellitus 的海马趾的 synaptic 和记忆混乱。最后,我们发现 TMP 处理恢复了胆碱能的神经原的功能。我们的数据建议 TMP 的那饮食的举起能在广告对存储器损失提供保护,并且 GSK-3 的抑制可以在这保护的效果起一个重要作用。 | Fen Lu Xu Li Wei Li Ke Wei Yong Yao Qianlin Zhang Xinliang Liang Jiewen Zhang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 9 |
| 6 | Corrosion resistance of Mg(OH)2/Mg-Al-layered double hydroxide coatings on magnesium alloy AZ31:influence of hydrolysis degree of silane显示文摘Mg(OH)2/Mg-Al-layered double hydroxide (LDH) coatings were modified with methyltrimethoxysilane (MTMS) on magnesium alloys. Effect of hydrolysis degree of silane solution on coating formation was investigated. Chemical compositions and surface morphologies of the coatings were examined using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and field-emission scanning electronic microscopy (FESEM). Results indicated that the composite coatings consisted of polymethyltrimethoxysilane (PMTMS), LDH and Mg(OH)2. Electrochemical and hydrogen evolution measurements revealed that the composite coatings possessed good corrosion resistance, especially the ones prepared in a high hydrolysis degree of silane. The optimum corrosion resistance of the composite coati ng was LDH/PMTMS-3 coating, which had the lowest value of corrosion current density (5.537×10^-9 A·cm^-2) and a dense surface.Plausible mechanism for coating formation and corrosion process of MTMS-modified Mg(OH)2/Mg-Al-LDH coatings were discussed. | Qing-Song Yao Zhong-Chao Li Zai-Meng Qiu Fen Zhang Xiao-Bo Chen Dong-Chu Chen Shao-Kang Guan Rong-Chang Zeng | 2019 | Rare Metals2019，38，7： | 9 |
| 7 | Central Obesity and Metabolic Risk Factors in Middle-aged Chinese显示文摘Objective Central obesity is considered to be a central component of metabolic syndrome. Waist circumference(WC) has been widely used as a simple indicator of central obesity. This study is aimed to evaluate the sensitivity of WC cut-off values for predicting metabolic risk factors in middle-aged Chinese. Methods The study involved 923 subjects aged 40-65 years. The metabolic risk factors were defined according to the Chinese Joint Committee for Developing Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults. WC cut-off 85-90 cm and ≥90 cm were used as cut-off values of central pre-obesity and central obesity in males, respectively, while WC 80-85 cm and ≥85 cm were used as cut-off values of central pre-obesity and central obesity in females. Results First, WC values corresponding to body mass index(BMI) 24 kg/m2 and visceral fat area(VFA) 80 cm2 were 88.55 cm and 88.51 cm in males, and 81.46 cm and 82.51 cm in females respectively. Second, receiver operating characteristic curves showed that the optimal WC cut-off of value was 88.75 cm in males, higher than that in females(81.75 cm). Third, the subjects with higher WC values were more likely to have accumulating metabolic risk factors. The prevalence of metabolic risk factors increased linearly and significantly in relation to WC levels. Conclusion WC cut-off values of central pre-/central obesity are optimal to predict multiple metabolic risk factors. | YIN Xue Yao ZHENG Fen Ping ZHOU Jia Qiang DU Ying PAN Qian Qian ZHANG Sai Fei YU Dan LI Hong | 2014 | Biomedical and Environmental Sciences2014，27，5： | 6 |
| 8 | Hadron Physics Programs at HIRFL-CSRm: Plan and Status显示文摘 | ZHENG Chuan XIAO Zhi-Gang XU Hu-Shan XIAO Guo-Qing ZHAN Wen-Long LI Zhan-Kui DUAN Li-Min SUN Zhi-Yu YAO Nan YUAN Xiao-Hua ZHANG Xue-Ying WANG Jian-Song CHEN Ruo-Fu FAN Rui-Rui FU Fen HUANG Tian-Heng LIANG Jin-Jie OUYANG Zhen YU Yu-Hong YUE Ke ZHANG Xue-Heng ZHANG Ya-Peng LI Xi-Guo LI Jin | 2007 | 高能物理与核物理2007，31，12： | 5 |
| 9 | Underlying Mechanisms of Memory Deficits Induced by Etomidate Anesthesia in Aged Rat Model: Critical Role of Immediate Early Genes显示文摘 | Xu Li Fen Lu Wei Li Jun Xu Xiao-Jing Sun LJng-Zhi Qin Qian-Lin Zhang Yong Yao Qing-Kai Yu Xin-Liang Liang | 2016 | Chinese Medical Journal2016，，1： | 4 |
| 10 | Cloning and expression of HLA-B7 gene显示文摘INTRODUCTIONInrecentyears,ithasbeenfoundthatHLAB7playsanimportantroleintheantigenpresentationandtheresearchofhumantumorthera... | QU Shen, LI Qing Fen, DENG Yao Zu, ZHANG Jian Ming and ZHANG Jie | 1999 | World Journal of Gastroenterology1999，5，4： | 4 |
| 11 | Provenance of Detrital Magnetites from Quaternary Sediments in the Yichang Area and its Significance to the Birth of the Three Gorges, Yangtze River显示文摘Objective In recent years,the birth time and evolution of the Three Gorges,Yangtze River has become a focused topic.Different from previous studies,this study used provenance analysis of Quaternary sediments to | XIANG Fang WANG Yuwan ZHANG Yao LI Shuxia WANG Jinyuan FEN Qin | 2016 | Acta Geologica Sinica(English Edition)2016，90，3： | 3 |
| 12 | Effects of Maternal Screening and Universal Immunization to Prevent Mother-to-Infant Transmission of HBV显示文摘 | Huey–Ling Chen Lung–Huang Lin Fu–Chang Hu Jian–Te Lee Wen–Terng Lin Yao–Jung Yang Fu–Chen Huang Shu–Fen Wu Solomon Chih–Cheng Chen Wan–Hsin Wen Chia–Hsiang Chu Yen–Hsuan Ni Hong–Yuan Hsu Pei–Lin Tsai Cheng–Lun Chiang Ming–Kwang Shyu Ping–Ing Lee Feng–Yee | 2012 | Gastroenterology2012，，4： | 2 |
| 13 | Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson’s disease显示文摘Inflammation is one of the pathogenic processes in Parkinson’s disease(PD).Dopamine receptor agonist pramipexole(PPX)is extensively used for PD treatment in clinics.A number of studies show that PPX exerts neuroprotection on dopaminergic(DA)neurons,but the molecular mechanisms underlying the protective effects of PPX on DA neurons are not fully elucidated.In the present study,we investigated whether PPX modulated PD-related neuroinflammation and underlying mechanisms.PD model was established in mice by bilateral striatum injection of lipopolyssaccharide(LPS).The mice were administered PPX(0.5 mg·kg−1·d−1,i.p.)3 days before LPS injection,and for 3 or 21 days after surgery,respectively,for biochemical and histological analyses.We showed that PPX administration significantly alleviated the loss of DA neurons,and suppressed the astrocyte activation and levels of proinflammatory cytokine IL-1βin the substantia nigra of LPS-injected mice.Furthermore,PPX administration significantly decreased the expression of NLRP3 inflammasome-associated proteins,i.e.,cleaved forms of caspase-1,IL-1β,and apoptosis-associated speck-like protein containing a caspase recruit domain(ASC)in the striatum.These results were validated in LPS+ATP-stimulated primary mouse astrocytes in vitro.Remarkably,we showed that PPX(100–400μM)dose-dependently enhanced the autophagy activity in the astrocytes evidenced by the elevations in LC3-II and BECN1 protein expression,as well as the increase of GFP-LC3 puncta formation.The opposite effects of PPX on astrocytic NLRP3 inflammasome and autophagy were eliminated by Drd3 depletion.Moreover,we demonstrated that both pretreatment of astrocytes with autophagy inhibitor chloroquine(40μM)in vitro and astrocyte-specific Atg5 knockdown in vivo blocked PPX-caused inhibition on NLRP3 inflammasome and protection against DA neuron damage.Altogether,this study demonstrates an anti-neuroinflammatory activity of PPX via a Drd3-dependent enhancement of autophagy activity in astrocytes,and reveals a new mechanism for the beneficial effect of PPX in PD therapy. | An-qi Dong Ya-ping Yang Shu-min Jiang Xiao-yu Yao Di Qi Cheng-jie Mao Xiao-yu Cheng Fen Wang Li-fang Hu Chun-feng Liu | 2023 | Acta Pharmacologica Sinica2023，44，1： | 2 |
| 14 | Biocorrosion resistance and biocompatibility of Mg-AI layered double hydroxide/poly(L-lactic acid) hybrid coating on magnesium alloy AZ31显示文摘A Mg-AI layered double hydroxide(Mg-AI-LDH)coating was firstly synthesized via an in-situ steam coating growth method on the AZ31 Mg alloy,and then was modified with poly(L-lactic acid)(PLLA)via dipping and vacuum freeze-drying.The microstructure and composition of LDH/PLLA hybrid coating were analyzed by XRD,SEM,EDS and FT-IR.The biocorrosion behavior of hybrid coating was evaluated by potentiodynamic polarization,electrochemical impedance spectroscopy(EIS)and hydrogen evolution test in the Hank's solution.The results showed that LDH/PLLA coatings exhibited a much dense layer compared to the unmodified Mg-AI-LDH coating with unobvious boundary between PLLA and LDH coatings.The corrosion current density of the LDH/PLLA-10 hybrid coating decreased three orders of magnitude in comparison to its substrate.It was proven that the existence of the PLLA coating further prolonged the service life of the Mg-AI-LDH coating.What's more,the MTT assay and livel dead staining showed that the LDH/PLL A-10 coating had good biocompatibility for Mouse NIH3T3 fibroblasts.The formation mechanism and the anti-corrosion mechanism of hybrid coatings were proposed. | Xiang SUN Qing-Song YAO Yu-Chao LI Fen ZHANG Rong-Chang ZENG Yu-Hong ZOU Shuo-Qi LI | 2020 | Frontiers of Materials Science2020，14，4： | 2 |
| 15 | Epidemiological Survey of Hemoglobinopathies Based on Next-Generation Sequencing Platform in Hunan Province,China显示文摘Objective This study was aimed at investigating the carrier rate of,and molecular variation in,α-andβ-globin gene mutations in Hunan Province.Methods We recruited 25,946 individuals attending premarital screening from 42 districts and counties in all 14 cities of Hunan Province.Hematological screening was performed,and molecular parameters were assessed.Results The overall carrier rate of thalassemia was 7.1%,including 4.83%forα-thalassemia,2.15%forβ-thalassemia,and 0.12%for bothα-andβ-thalassemia.The highest carrier rate of thalassemia was in Yongzhou(14.57%).The most abundant genotype ofα-thalassemia andβ-thalassemia was-α^(3.7)/αα(50.23%)andβ^(IVS-Ⅱ-654)/β^(N)(28.23%),respectively.Fourα-globin mutations[CD108(ACC>AAC),CAP+29(G>C),Hb Agrinio and Hb Cervantes]and sixβ-globin mutations[CAP+8(C>T),IVS-Ⅱ-848(C>T),-56(G>C),beta nt-77(G>C),codon 20/21(-TGGA)and Hb Knossos]had not previously been identified in China.Furthermore,this study provides the first report of the carrier rates of abnormal hemoglobin variants andα-globin triplication in Hunan Province,which were 0.49%and 1.99%,respectively.Conclusion Our study demonstrates the high complexity and diversity of thalassemia gene mutations in the Hunan population.The results should facilitate genetic counselling and the prevention of severe thalassemia in this region. | XI Hui LIU Qin XIE Dong Hua ZHOU Xu TANG Wang Lan TANG De Guo ZENG Chun Yan WANG Qiong NIE Xing Hui PENG Jin Ping GAO Xiao Ya WU Hong Liang ZHANG Hao Qing QIU Li FENG Zong Hui WANG Shu Yuan ZHOU Shu Xiang HE Jun ZHOU Shi Hao ZHOU Fa Qun ZHENG Jun Qing WANG Shun Yao CHEN Shi Ping ZHENG Zhi Fen MA Xiao Yuan FANG Jun Qun LIANG Chang Biao WANG Hua | 2023 | Biomedical and Environmental Sciences2023，36，2： | 1 |
| 16 | A quartz crystal microbalance sensor based on mussel - inspired mo- lecularly imprinted polymer显示文摘 | Zhou Wen - hui Tang Shui - fen Yao Qiu - hong | 2010 | Biosens Bioelectron2010，26，： | 1 |
| 17 | The dynamic behavior of a gas bubble near a wall 显示文摘 | Zhang A M Yao X L Fen L H | 2009 | Ocean Engineering2009，36，： | 1 |
| 18 | A quartz crystal microbalance sensor based on mussel-in spired molecularly imprinted polymer显示文摘 | ZH()U Wen Hui TANG Shui Fen YAO Qiu Hong | 2010 | Biosens Bioelectron2010，26，58： | 1 |
| 19 | Preparation and application of VE microcapsules with polyurethane shell for skin-care textiles 显示文摘 | YAO Guo Ping ZHENG Jin Huan CHEN Hui Fen | 2011 | Advances in Textile Engineering2011，331，： | 1 |
| 20 | RNF114 suppresses metastasis through regulation of PARP10 in cervical cancer cells显示文摘Dear editor,ADP-ribosylation is a post-translational modification catalysed by poly(ADP-ribose)polymerases(PARPs)and plays important roles in diverse biological processes,such as DNA repair,chromatin remodelling,telomere homeostasis,transcription,chromosome segregation,cell proliferation,and cell death[1,2].While much is known about the cellular roles of PARPs that catalyse polyADP ribosylation,the function of the PARPs that catalyse monoADP ribosylation is substantially less understood. | Yahui Zhao Xiao Liang Li Wei Yao Liu Juan Liu Huan Feng Fen Zheng Ying Wang Haijie Ma Jiaxue Wu | 2021 | Cancer Communications2021，41，2： | 1 |
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