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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | A semi-automated in vitro gas production technique for ruminant feedstuff evaluation显示文摘 | Rogerio M Mauricio Fergus L Mould Mewa S Dhanoa Emyr Owen Kulwant S Channa Michael K Theodorou | 1999 | Animal Feed Science and Technology1999，，4： | 2 |
| 3 | Use of the scored Patient Generated Subjective Global Assessment (PG-SGA) as a nutrition assessment tool in patients with cancer 显示文摘 | Bauer J Capra S Fergus on M | 2002 | Eur J Clin Nutr2002，56，8： | 1 |
| 4 | Adolescent resilience:a framework for understanding healthy development in the face of risk显示文摘 | Fergus S Zimmerman M A | | 0，，： | 1 |
| 5 | Removing camera shake from a single photograph 显示文摘 | Fergus R Barun S | 2006 | ACM Transactions on Graphics (TOG)2006，3，25： | 1 |
| 6 | Local staging of prostate canc- er: comparative accuracy of T2-weighted endorectal MR imaging and transrectal ultrasound 显示文摘 | Adam J J Fergus VC Katsuto S | 2012 | Clinical Imaging2012，36，5： | 1 |
| 7 | Mephedrone (4-methyl- methcathinone ; ' meow meow' ) : chemical, pharmacological and clinical issues 显示文摘 | Schifano F Albanese A Fergus S | 2011 | Psychopharmacology (Berl)2011，214，3： | 1 |
| 8 | Mephedrone ( 4 - methylmetheathinone ; 'meow meow' ) : chemical, pharmacological and clinical issues 显示文摘 | Sehifano F Albanese A Fergus S | 2011 | Psychopharmacology ( Berl)2011，214，3： | 1 |
| 9 | Is a STAS-based tool valid to triage patients at a specialist palliative care inpa- tient unit? 显示文摘 | Fergus C J Nicol J S Russell P B | 2008 | Int J Palliat Nuts2008，14，1： | 1 |
| 10 | Adolescent resilience: a frame work for understanding healthy development in the face of risk显示文摘 | Fergus S Zimmerman MA | 2005 | Annu Rev Publ Health2005，26，： | 1 |
| 11 | IgG - Mediated food intolerance in Irritable Bowel Syndrome: a real phenomenon or an Eplphenomenom显示文摘 | Fergus S Peter J | 2005 | Am J Gastroenterol2005，100，7： | 1 |
| 12 | Mephedrone(4-methylmethcathinone;'meow meow'):chemical,pharmacologicaland clinical issues显示文摘 | Schifano F Albanese A Fergus S | 2011 | Psychopharmacology(Berl)2011，214，3： | 1 |
| 13 | Levels of processing:A Framework for Memory Research显示文摘 | FERGUS C LOCKHART R S | 1972 | Journal of Verbal Leaning and Verbal Behavior1972，，11： | 1 |
| 14 | Adolescent resilience:A framework for un-derstanding healthy development in the face of risk显示文摘 | Fergus S Zimmerman MA | 2005 | Annual Review of Public Health2005，26，2： | 1 |
| 15 | Multiscalelandscape and wetland drivers of lake total phosphorus and watercolor 显示文摘 | Fergus C E Soranno P A Cheruvelil K S | 2011 | Limnology and Oceanography2011，56，6： | 1 |
| 16 | Inflammatory bowel disease: immunodiagnostics, immunotherapeutics, and ecotherapeutics显示文摘 | Fergus S | 2001 | Gastroenterology2001，120，3： | 1 |
| 17 | Adolescent resilience:A framework forunderstanding healthy development in the face of risk 显示文摘 | Fergus S Zimmerman M A | 2005 | Annual Review of Public Health2005，26，1： | 1 |
| 18 | Adolescent resilience:A framework for understanding healthy development in the face of risk显示文摘 | Fergus S Zimmerman MA | | 0，，： | 1 |
| 19 | Bowel transition points:multiplicity and posterior location at CT are associated with small-bowel volvulus显示文摘 | Parmbir S Bonnie N Fergus V | 2007 | Radiology2007，245，： | 1 |
| 20 | Local staging of prostate cancer: comparative accuracy of T2-weighted endorectal MR imaging and transrectal ultrasound显示文摘 | Adam JJ Fergus VC Katsuto S | 2012 | Clinical Imaging2012，36，5： | 1 |
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