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| 1 | 常规脂蛋白检测和载脂蛋白在心血管病预测中的比较显示文摘总胆固醇和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)测量值对于心血管病风险评估至关重要,但对于其他脂质用于风险预测的效用一直存在争议。该研究纳入来自英国生物银行(Biobank)的无基线心血管病、未服用他汀类药物、有相关的脂质指标(n=346 686)的受试者。 | Welsh C Celis-Morales CA Brown R Mackay DF Lewsey J Mark PB Gray SR Ferguson LD Anderson JJ Lyall DM Cleland JG Jhund PS Gill J MR Pell JP Sattar N Welsh P 刘青(译) 叶鹏(摘、审校) | 2019 | 中华高血压杂志2019，27，7： | 10 |
| 2 | Why interleukin-10 supplementation does not work in Crohn's disease patients显示文摘Inflammatory bowel diseases (IBD) such as Crohn's disease (CD) or ulcerative colitis are chronic intestina disorders, which are on the increase in 'Westernised' countries. IBD can be caused by both genetic and environmental factors. Interleukin-10 (IL-10) is an immunoregulatory cytokine that has been identified as being involved in several diseases including IBD. Studies have shown that polymorphisms in the promoter region reduce serum levels of IL-10 and this reduction has been associated with some forms of IBD. Mouse models have shown promising results with IL-10 supplementation, as such IL-10 supplementation has been touted as being a possible alternative treatment for CD in humans. Clinical trials have shown that recombinant human IL-10 is safe and well tolerated up to a dose o 8 μg/kg. However, to date, the results of the clinica trials have been disappointing. Although CD activity was reduced as measured by the CD activity index IL-10 supplementation did not result in significantly reduced remission rates or clinical improvements when compared to placebo. This review discusses why IL-10supplementation is not effective in CD patients currently and what can be addressed to potentially make IL-10 supplementation a more viable treatment option in the future. Based on the current research we conclude that IL-10 supplementation is not a one size fits all treatment and if the correct population of patients is chosen then IL-10 supplementation could be of benefit. | Gareth J Marlow Dominique van Gent Lynnette R Ferguson | 2013 | World Journal of Gastroenterology2013，19，25： | 9 |
| 3 | Vertebroplasty and kyphoplasty :a systematic review of 69 clinical studies显示文摘 | Hulme PA Krebs J Ferguson S J | 2006 | Spine2006，31，17： | 3 |
| 4 | Cytotoxic CD8+ T cells and tissue resident memory cells in colorectal cancer based on microsatellite instability and BRAF status显示文摘BACKGROUND Recent studies in non-colorectal malignancy have associated T resident memory(T_(RM)) cells with improved patient survival. It is unknown if T_(RM) plays a role in colorectal cancer(CRC).AIM To examine the potential role of T_(RM) cells in providing immunogenicity in CRC stratified by microsatellite instability(MSI) and BRAF status.METHODS Patients with known MSI and BRAF mutation status were eligible for inclusion in this study. CRC tumour sections stained with haematoxylin and eosin were microscopically reviewed and the images scanned prior to assessment for location of invading edge and core of tumour. Sequential sections were prepared for quantitative multiplex immunohistochemistry(IHC) staining. Opal Multiplex IHC staining was performed with appropriate positive and negative controls and imaged using a standard fluorescent microscope fitted with a spectral scanning camera(Mantra) in conjunction with Mantra snap software. Images were unmixed and annotated in in Form 2.2.0. Statistical analysis was performed using Graphpad Prism Version 7 and Stata Version 15.RESULTS Seventy-two patients with known MSI and BRAF status were included in the study. All patients were assessed for MSI by IHC and high resolution capillary electrophoresis testing and 44 of these patients successfully underwent quantitative multiplex IHC staining. Overall, there was a statistically significant increase in CD8+ T_(RM) cells in the MSI(BRAF mutant and wild type) group over the microsatellite stable(MSS) group. There was a statistically significant difference in CD8+ T_(RM) between high level MSI(MSI-H):BRAF mutant [22.57, 95% confidence interval(CI): 14.31-30.84] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0076 and MSI-H:BRAF wild type [16.18(95%CI: 10.44-21.93)] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0279. There was no statistically significant difference in CD8 T cells(both CD8+CD103-and CD8+CD103+T_(RM)) between MSI-H: BRAF mutant and wild type CRC.CONCLUSION This study has shown that CD8+ T_(RM) are found in greater abundance in MSI-H CRC, both BRAF mutant and MSI-H:BRAF wild type, when compared with their MSS counterpart. CD8+ T_(RM) may play a role in the immunogenicity in MSI-H CRC(BRAF mutant and BRAF wild type). Further studies should focus on the potential immunogenic qualities of T_(RM) cells and investigate potential immunotherapeutic approaches to improve treatment and survival associated with CRC. | James Wei Tatt Toh Angela L Ferguson Kevin J Spring Hema Mahajan Umaimainthan Palendira | 2021 | World Journal of Clinical Oncology2021，12，4： | 2 |
| 5 | Vertebroplasty and Kyphoplasty: A Systematic Review of 69 Clinical Studies显示文摘 | Paul A. Hulme J?rg Krebs Stephen J. Ferguson Ulrich Berlemann | 2006 | Spine2006，，17： | 2 |
| 6 | Inductive fault analysis of MOS integrated circuits显示文摘 | Shen J Maly W Ferguson F | 1985 | IEEE Design and Test of Computers1985，2，12： | 2 |
| 7 | Use of the scored Patient-Generated Subjective Global Assessment (PG-SGA) as a nutrition assessment tool in patients with cancer显示文摘 | Bauer J Capra S Ferguson M | 2002 | Eur J Clin Nutr2002，56，： | 1 |
| 8 | Expression of human papillomavirus type 16L1 protein in Escherichiacoli:Denaturation, Renaturation, and self- assembly of virus- like particle in vitro显示文摘 | Carmichael J Ferguson J | 1998 | Viology1998，243，： | 1 |
| 9 | Vertebroplasty and kyphoplasty:A systmatic review of 69 clinical studies显示文摘 | Krebs J Ferguson SJ | 2006 | Spine2006，31，17： | 1 |
| 10 | The localization of target antigens and autoantibodies in linear IgA disease is variable; correlation of immunogold electron microscopy and immunoblotting显示文摘 | Zhou S Ferguson DJ Allen J | 1998 | Br J Dermatol1998，139，： | 1 |
| 11 | Vertebroplasty and kyphoplasty:a systematic review of 69 clinical studies显示文摘 | Hulme PA Krebs J Ferguson SJ | 2006 | Spine2006，31，17： | 1 |
| 12 | Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic endothelium 显示文摘 | PREVO R BANERJI S FERGUSON D J | 2001 | J Biol Chem2001，276，19： | 1 |
| 13 | A mechanistic classification of thora- columbar spine fractures 显示文摘 | Ferguson RL Allen BL J r | 1984 | Clin Orthop Relat Res1984，，189： | 1 |
| 14 | The surgical management of bacterial valvular endocarditis显示文摘 | Ferguson E Reardon M J Letsou GV | 2000 | Curr Opin Cardiol2000，15，： | 1 |
| 15 | An assay combining cell cμLture with reverse transcriptase PCR to detect and determine the infectivity of waterborne Cryptosporidium parvum显示文摘 | Rochelle P A Ferguson D M Handojo T J | 1997 | Appl Environ Microbiol1997，63，5： | 1 |
| 16 | An ELISA for the detection of Bacillus subtilis L-form bacteria confirms their symbiosis in strawberry显示文摘 | FERGUSON C M J BOOTHL N A ALLAN E J | 2000 | Lett in Appl Microbiol2000，31，： | 1 |
| 17 | Constrained invemion of seismic refraction data using the controlled random search显示文摘 | Smith D N Ferguson J F | 2000 | Geophysics2000，65，5： | 1 |
| 18 | Effect of vertebral cement augmentation with polymethylmethacrylate on intervertebral disc and bone tissue 显示文摘 | Krebs J Ferguson SJ Goss BG | 2012 | J Biomed Mater Res B Appl Biomater2012，100，3： | 1 |
| 19 | Detection of chloramphenicol and chloramphenicol glucuronide residues in poultry muscle,honey,prawn and milk using a surface plasmon resonance biosensor and Qflex kit chloramphenicol显示文摘 | Ferguson J Baxter A Young P | 2005 | Anal Chim Acta2005，529，： | 1 |
| 20 | Scar formation: the spectral nature of fetal and adult wound repair显示文摘 | Ferguson MW Whitby D J Shah M | | 0，，： | 1 |
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