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| 1 | Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics显示文摘Multiple myeloma is a hematological malignancy inwhich clonal plasma cells proliferate and accumulate within the bone marrow. The presence of osteolytic le-sions due to increased osteoclast(OC) activity and sup-pressed osteoblast(OB) function is characteristic of the disease. The bone marrow mesenchymal stromal cells(MSCs) play a critical role in multiple myeloma patho-physiology, greatly promoting the growth, survival, drug resistance and migration of myeloma cells. Here, we specifically discuss on the relative contribution of MSCs to the pathophysiology of osteolytic lesions in light of the current knowledge of the biology of my-eloma bone disease(MBD), together with the reported genomic, functional and gene expression differences between MSCs derived from myeloma patients(pMSCs) and their healthy counterparts(dMSCs). Being MSCs the progenitors of OBs, pMSCs primarily contribute to the pathogenesis of MBD because of their reduced osteogenic potential consequence of multiple OB inhibi-tory factors and direct interactions with myeloma cells in the bone marrow. Importantly, pMSCs also readily contribute to MBD by promoting OC formation and ac-tivity at various levels(i.e., increasing RANKL to OPG expression, augmenting secretion of activin A, uncou-pling ephrinB2-EphB4 signaling, and through augment-ed production of Wnt5a), thus further contributing to OB/OC uncoupling in osteolytic lesions. In this review, we also look over main signaling pathways involved in the osteogenic differentiation of MSCs and/or OB activity, highlighting amenable therapeutic targets; in parallel, the reported activity of bone-anabolic agents(at preclinical or clinical stage) targeting those signaling pathways is commented. | Antonio Garcia-Gomez Fermin Sanchez-Guijo M Consuelo del Caizo Jesus F San Miguel Mercedes Garayoa | 2014 | World Journal of Stem Cells2014，6，3： | 5 |
| 2 | Region growing with pulse-coupled neural networks: an alternative to seeded re-gion growing 显示文摘 | Stewart R D Fermin I Opper M | 2002 | IEEE Transactions on Neural Networks2002，13，6： | 1 |
| 3 | Evidence for model- based action planning in a sequential finger movement task显示文摘 | FERMIN A YOSHIDA T ITO M | 2010 | J Motor Behavior2010，42，6： | 1 |
| 4 | Region growing with pulse-coupled neural networks: an alternative to seeded region grow- ing 显示文摘 | STEWART R D FERMIN I OPPER M | 2002 | IEEE Transactions on Neural Network2002，13，6： | 1 |
| 5 | In-stent restenosis:contributions of inflammatory responses and arterial injury to neointimal hyperplasia显示文摘 | Kornowski R Hong M Fermin F | 1998 | J Am Coll Cardiol1998，31，1： | 1 |
| 6 | Papaya ringspot virus resistance of transgenic rainbow and sunup is affected by gene dosage,plant development,and coat protein homology显示文摘 | ENNANT P FERMIN G FITICH M M | 2001 | European Journal of Plant Pathology2001，107，： | 1 |
| 7 | Universal and Reconfigurable to UPS Active Power Filter for Line Conditioning显示文摘 | FERMIN B SALVADOR M FERNANDO Y | | 0，，01： | 1 |
| 8 | Quantitative contribution of NHE2 and NHE3 to rabbit ileal brush-bordrer Na^+/H^+ exchange显示文摘 | WORMMEESTER L FERMIN S M FREDDY K | 1998 | Am J Physiol1998，274，： | 1 |
| 9 | Dyspepsia and irritable bowel syndrome after a salmonella gastroenteritis outbreak: one-year follow-up cohort study显示文摘 | Fermin M Marc P Antonia P | 2005 | Gastroenterology2005，129，1： | 1 |
| 10 | Papaya rings-pot virus resistance of transgenic Rainbow and SunUp is affected by gene dosage,plant development,and coat protein homology显示文摘 | Tennant P Fermin G Fitch M M | 2001 | European Journal of Plant Pathology2001，107，： | 1 |
| 11 | Ablation of ventricular arrhythmias arising near the anterior epicardial veins from the left sinus of Valsalva region: ECG features, anatomic distance, and outcome显示文摘 | Miguel E. Jauregui Abularach Bieito Campos Kyoung-Min Park Cory M. Tschabrunn David S. Frankel Robert E. Park Edward P. Gerstenfeld Stavros Mountantonakis Fermin C. Garcia Sanjay Dixit Wendy S. Tzou Mathew D. Hutchinson David Lin Michael P. Riley Joshua M | 2012 | Heart Rhythm2012，，6： | 1 |
| 12 | Effect of Epinephelus coioides , Chanos chanos , and GIFT tilapia in polyculture with Penaeus monodon on the growth of the luminous bacteria Vibrio harveyi 显示文摘 | Tendencia E A Fermin A C dela Pefia M R | 2006 | Aquaculture2006，253，14： | 1 |
| 13 | Reproductive performance of hatchery-bred donkey's ear abalone, Haliotis asinine Linne, fed natural and artificial diets 显示文摘 | Teruel M N Millamena O M Fermin A C | 2001 | Aquaculture Research2001，32，11： | 1 |
| 14 | Effect of temperature on the ferromagnetic resonance of Ni50Fe50 thin films 显示文摘 | de SIHUES SILVA M D P J FERMIN J R | 2004 | Physica B2004，354，14： | 1 |
| 15 | Region growing with pulse-coupled neural networks:an alternative to seeded region growing显示文摘 | Stewart RD Fermin I Opper M | 2002 | IEEE Trans Neural Netw2002，13，6： | 1 |
| 16 | Region Growing With Pulse-Coupled Neural Networks:An Alternative to Seeded Region Growing显示文摘 | Fermin I Opper M | 2002 | IEEE Transactions on Neural Networks2002，13，6： | 1 |
| 17 | Region growing with pulse-coupled neural networks: An alternative to seeded region growing显示文摘 | Stewart R D Fermin I Opper M | 2002 | IEEE Transaction on Neural Networks2002，13，6： | 1 |
| 18 | Multiresidue Method for the Determination of Quinolone Antibiotics in Bovine Raw Milk by Capillary Electrophoresis - Tandem Mass Spectrometry 显示文摘 | Francisco J Lara Ana M Garcfa - Campaea Fermin Ales - Barre- ro | 2006 | Anal Chem2006，78，22： | 1 |
| 19 | A kinetic study of CdS photocorrosion by intensity modulated photocurrent and photoelectrochemical impedance spectroscopy显示文摘 | FERMIN D J PONOMAREV E A PETER L M | 1999 | Journal of Electroanalytical Chemistry1999，473，12： | 1 |
| 20 | Effect of Epinephelus coioides,Chanos chanos,and GIFT tilapiain polyculture with Penaeus monodon on the growth of the luminous bacteria Vibrio harveyi显示文摘 | TENDENCIA E A FERMIN A C DELAPENA M R | 2006 | Aquaculture2006，253，1： | 1 |
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