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| 1 | The role of structural inheritance in continental break-up and exhumation of Alpine Tethyan mantle(Canavese Zone,Western Alps)显示文摘The Canavese Zone(CZ)in the Western Alps represents the remnant of the distal passive margin of the Adria microplate,which was stretched and thinned during the Jurassic opening of the Alpine Tethys.Through detailed geological mapping,stratigraphic and structural analyses,we document that the continental break-up of Pangea and tectonic dismemberment of the Adria distal margin,up to mantle rocks exhumation and oceanization,did not simply result from the syn-rift Jurassic extension but was strongly favored by older structu ral inheritances(the Proto-Canavese Shear Zone),which controlled earlier lithospheric weakness.Our findings allowed to redefine in detail(i)the tectono-stratigraphic setting of the Variscan metamorphic basement and the Late Carbonife rous to Early Cretaceous CZ succession,(ii)the role played by inherited Late Carboniferous to Early Triassic structures and(iii)the significance of the CZ in the geodynamic evolution of the Alpine Tethys.The large amount of extensional displacement and crustal thinning occurred during different pulses of Late Carbonife rous-Early Triassic strike-slip tectonics is wellconsistent with the role played by long-lived regional-scale wrench faults(e.g.,the East-Variscan Shear Zone),suggesting a re-discussion of models of mantle exhumation driven by low-angle detachment faults as unique efficient mechanism in stretching and thinning continental crust. | Andrea Festa Gianni Balestro Alessandro Borghi Sara De Caroli Andrea Succo | 2020 | Geoscience Frontiers2020，11，1： | 4 |
| 2 | Subcutaneous sarcoidosis of the upper and lower extremities: A case report and review of the literature显示文摘BACKGROUND Sarcoidosis is a granulomatous disease of unknown etiology that most often impacts the lungs.Cutaneous manifestations of sarcoidosis are seen among 9%- 37% of patients.Subcutaneous sarcoidosis is a rare presentation of cutaneous sarcoidosis with estimates of frequency ranging from 1.4%-16%.To date,very few articles and case reports have been written about this subject.In this paper,we describe a case of subcutaneous sarcoidosis and perform a review of the literature to determine if there are commonalities among patients who present with subcutaneous sarcoidosis.CASE SUMMARY A 38-year-old female,with a past medical history of arthritis and recurrent nephrolithiasis,presents with an 8-mo history of 4 firm,asymptomatic,skincolored nodules on her left and right upper extremities and neck.Needle biopsy and post-excisional pathology report both revealed well-formed,dense,noncaseating granulomas localized to the subcutaneous tissue.Chest computed tomography revealed mild mediastinal lymphadenopathy.A diagnosis of subcutaneous sarcoidosis was made,and the lesions were surgically removed.CONCLUSION Commonalities among patients presenting with subcutaneous sarcoidosis include: middle-aged female,lesions localizing to the upper or lower limbs,lymphadenopathy or pulmonary infiltration on chest imaging,elevated serum angiotensin-converting enzyme. | Raman Mehrzad Julia Festa Reena Bhatt | 2019 | World Journal of Clinical Cases2019，7，17： | 3 |
| 3 | Anti-inflammatory and analgesic activities with gastroprotective effect of semi-purified fractions and isolation of pure compounds from Mediterranean gorgonian Eunicella singularis显示文摘Objective: To explore anti-inflammatory activities of organic extract and its semi-purified fractions(ethanol, acetone, methanol/dichloromethane) from the Mediterranean gorgonian Eunicella singularis. Methods: The anti-inflammatory and analgesic activities were evaluated, using the carrageenan-induced rat paw edema model and the acetic acid writhing test in mice. The gastroprotective activity was determined using HCl/Et OH induced gastric ulcers in rats. The purification and structure elucidation of compound(s) from the more effective fraction were determined by chromatographic and spectroscopic methods and in comparison with data reported in the literature. Results: The fraction F-Et OH showed an important antiinflammatory activity associated with significant analgesic and gastroprotective properties. The purification and structure elucidation of compound(s) from this fraction lead to the identification of one diterpenoid and four sterols. Conclusions: These results suggested that components from the active fraction can be used to treat various anti-inflammatory diseases. | Monia Deghrigue Carmen Festa Lotfi Ghribi Maria Valeria D’Auria Simona De Marino Hichem Ben Jannet Abderrahman Bouraoui | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，8： | 2 |
| 4 | A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study显示文摘 | M. A. Nauck S. Duran D. Kim D. Johns J. Northrup A. Festa R. Brodows M. Trautmann | 2007 | Diabetologia2007，，2： | 2 |
| 5 | Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes; the insulin resistance atherosclerosis study显示文摘 | Festa A DAgostino R Jr Tracy RP | 2002 | Diabetes2002，51，4： | 1 |
| 6 | Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS) 显示文摘 | Festa A D'Agostino R Jr Howard G | 2000 | Circulation2000，102，1： | 1 |
| 7 | Metabolic and inflammation variable clusters and prediction of type 2 diabetes:factor analysis using directly measured insulin sensitivity显示文摘 | Hanley AJ Festa A D′Agostino RB | 2004 | Diabetes2004，53，7： | 1 |
| 8 | Elevated levels of acute phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes:The Insulin Resistance Atherosclerosis Study显示文摘 | Festa A Ralph DA Russell P | 2002 | Diabetes2002，51，4： | 1 |
| 9 | Chronic subclinical inflammation as part of the insulin resistance syndrome显示文摘 | Festa A Agostno RD | 2000 | Circulation2000，102，： | 1 |
| 10 | Chronic subclinical inflammation as part of the insulin-resistance syndrome: the insulin resistance atherosclerosis study (IRAS)显示文摘 | Festa A D Agostino R Jr Howard G | 2000 | Circulation2000，102，1： | 1 |
| 11 | Chronic sub-clinical inflammation as part of the insulin resistance syn-drome:the insulin restance atherosclerosis study(IRSA)显示文摘 | Festa A D Agostion R J R Howard G | 2000 | Circulation2000，102，： | 1 |
| 12 | Chronic sub clinical inflammation as part of the insulin resistance syn drome: the insulin resistance atherosclerosis study (IRAS) 显示文摘 | Festa A D'Agostino R Jr Howard G | 2000 | Circulation2000，102，1： | 1 |
| 13 | Chronic subclinical in- flammation as part of the insulin resistance syndrome:the Insu- lin Resistance Atherosclerosis Study (IRAS) 显示文摘 | Festa A D'Agostino R Howard G | 2000 | Circulation2000，102，1： | 1 |
| 14 | Impact of weight loss on inflammatory proteins and their association with the insulin resistance syndrome in morbidly obese patients显示文摘 | KOPP H P KOPP C W FESTA A | 2003 | Arterioscler Thromb Vasc Biol2003，23，6： | 1 |
| 15 | Elevated level of acute phaso proteinsan plasminogen activator inhibitor predict the development of type 2 diabetes 显示文摘 | Festa A Agostino R Tracy RP | 2002 | Diabetes2002，51，4： | 1 |
| 16 | Prevalence of signs and symptoms of temporomandibular disorders in children and adolescents with and without crossbites显示文摘 | Tecco S Festa F | 2010 | World J Orthod2010，11，： | 1 |
| 17 | Intraduodenal lipase activity in celiac disease assessed by means of ^13 C mixed triglyceride breath test显示文摘 | Perri F Pastore M Festa V | 1998 | J Pediatr Gastroenterol Nutr1998，7，4： | 1 |
| 18 | Dexamethasone inhibits TRAIL-induced apoptosis of thyroid cancer via Bcl-x(L) induction显示文摘 | Petrella A Ercolino SF Festa M | 2006 | Eur J Cancer2006，42，18： | 1 |
| 19 | Hydrocele of the canal of Nuck显示文摘 | Schneider CA Festa S Spillert CR | 1994 | N J Med1994，91，1： | 1 |
| 20 | Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors, design, synthe- sis, and biological evaluation of novel ligands 显示文摘 | Di Leva FS Festa C D'Amore C | 2013 | J Med Chem2013，6，11： | 1 |
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