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| 1 | Performance of the Montreal classification for inflammatory bowel diseases显示文摘AIM:To validate the Montreal classification system for Crohn's disease(CD) and ulcerative colitis(UC) within the Netherlands.METHODS:A selection of 20 de-identified medical records with an appropriate representation of the inflammatory bowel disease(IBD) sub phenotypes were scored by 30 observers with different professions(gastroenterologist specialist in IBD,gastroenterologist in training and IBD-nurses) and experience level with IBD patient care.Patients were classified according to the Montreal classification.In addition,participants were asked to score extra-intestinal manifestations(EIM) and disease severity in CD based on their clinical judgment.The inter-observer agreement was calculated by percentages of correct answers(answers identical to the 'expert evaluation') and Fleiss-kappa(k).Kappa cutoffs:< 0.4-poor; 0.41-0.6-moderate; 0.61-0.8-good; > 0.8 excellent.RESULTS:The inter-observer agreement was excellent for diagnosis(k = 0.96),perianal disease(k = 0.92) and disease location in CD(k = 0.82) and good for age of onset(k = 0.67),upper gastrointestinal disease(k = 0.62),disease behaviour in CD(k = 0.79) and disease extent in UC(k = 0.65).Disease severity in UC was scored poor(k = 0.23).The additional items resulted in a good inter-observer agreement for EIM(k = 0.68) and a moderate agreement for disease severity in CD(k = 0.44).Percentages of correct answers over all Montreal items give a good reflection of the inter-observer agreement(> 80%),except for disease severity(48%-74%).IBD-nurses were significantly worse in scoring upper gastrointestinal disease in CD compared to gastroenterologists(P = 0.008) and gastroenterologists in training(P = 0.040).Observers with less than 10 years of experience were significantly better at scoring UC severity than observers with 10-20 years(P = 0.003) and more than 20 years(P = 0.003) of experience with IBD patient care.Observers with 10-20 years of experience with IBD patient care were significantly better at scoring upper gastrointestinal disease in CD than observers with less than 10 years(P = 0.007) and more than 20 years(P = 0.007) of experience with IBD patient care.CONCLUSION:We found a good to excellent interobserver agreement for all Montreal items except for disease severity in UC(poor). | Lieke M Spekhorst Marijn C Visschedijk Rudi Alberts Eleonora A Festen Egbert-Jan van der Wouden Gerard Dijkstra Rinse K Weersma | 2014 | World Journal of Gastroenterology2014，20，41： | 4 |
| 2 | The prevalence of Helicobact er pylori in peptic ulcer disease显示文摘 | Kuipers E J Thijs J C Festen H P | 1995 | Aliment Pharmacol Ther1995，9，： | 1 |
| 3 | Fractures of the lateral hu- meral condyle in children: late results 显示文摘 | van Vugt AB Severijnen RV Festen C | 1988 | Arch Orthop Trauma Surg1988，107，： | 1 |
| 4 | Perianal abscess and fistula in ano in infants显示文摘 | Festen C Harten H | 1998 | J Pediatr Surg1998，33，： | 1 |
| 5 | Perianal abscess and fistula-in-ano in infants显示文摘 | Festen C van Harten H | 1998 | J Pediatr Surg1998，，33： | 1 |
| 6 | The prevalence of Helicobacter pylori in peptic ulcer disease显示文摘 | Thijs C Festen HPM | 1995 | Aliment Pharmacol Ther1995，9，2： | 1 |
| 7 | Quality of life after operatively corrected high anorectal malformation:a long follow-up study of patients aged 18 years and older显示文摘 | Hassink E A M Rieu P N M A Brugman A T M Festen C | 1994 | Journal of Pediatric Surgery1994，29，6： | 1 |
| 8 | The prevalence of Helicobacter pylori in peptic ulcer disease 显示文摘 | Kuipers E J Thijs J C Festen H P | 1995 | Aliment Pharmacol Tiler1995，9，2： | 1 |
| 9 | Temperament and parenting predicting anxiety change in cognitive behavioral therapy:The role of mothers fathers and children显示文摘 | FESTEN H HARTMAN C A HOGENDOOM S | | 0，，03： | 1 |
| 10 | The prevalence of Helicobacter pylori in peptic ulcer disease显示文摘 | Kuiper E J Thijs C Festen HPM | 1995 | Aliment Pharmacol Ther1995，9，2： | 1 |
| 11 | Perianal abscess and fistula-in-ano in infants显示文摘 | Festen C van Harten H | 1998 | J Pediatr Surg1998，33，： | 1 |
| 12 | Prevalence of-and risk factors for work disability in Dutch patients with inflammatory bowel disease显示文摘AIM To determine the prevalence of work disability in inflammatory bowel disease(IBD), and to assess risk factors associated with work disability.METHODS For this retrospective cohort study, we retrieved clinical data from the Dutch IBD Biobank on July 2014, containing electronic patient records of 3388 IBD patients treated in the eight University Medical Centers in the Netherlands. Prevalence of work disability was assessed in 2794 IBD patients and compared with the general Dutch population. Multivariate analyses were performed for work disability(sick leave, partial and full disability) and long-term full work disability(> 80% work disability for > 2 years).RESULTS Prevalence of work disability was higher in Crohn's disease(CD)(29%) and ulcerative colitis(UC)(19%) patients compared to the general Dutch population(7%). In all IBD patients, female sex, a lower education level, and extra-intestinal manifestations, were associated with work disability. In CD patients, an age > 40 years at diagnosis, disease duration > 15 years,smoking, surgical interventions, and anti-TNFα use were associated with work disability. In UC patients, an age > 55 years, and immunomodulator use were associated with work disability. In CD patients, a lower education level(OR = 1.62, 95%CI: 1.02-2.58), and in UC patients, disease complications(OR = 3.39, 95%CI: 1.09-10.58) were associated with long-term full work disability.CONCLUSION The prevalence of work disability in IBD patients is higher than in the general Dutch population. Early assessment of risk factors for work disability is necessary, as work disability is substantial among IBD patients. | Lieke M Spekhorst Bas Oldenburg Ad A van Bodegraven Dirk J de Jong Floris Imhann Andrea E van der Meulen-de Jong Marieke J Pierik Janneke C van der Woude Gerard Dijkstra Geert D'Haens Mark Lowenberg Rinse K Weersma Eleonora AM Festen 无 | 2017 | World Journal of Gastroenterology2017，23，46： | 1 |
| 13 | Temperament and parenting predicting anxiety change in cognitive behavioral thera- py: The role of mothers, fathers, and children显示文摘 | FESTEN H HARTMAN C A HOGENDOORN S | 2013 | J Anxiety Disord2013，27，3： | 1 |
| 14 | Multi-ethnic studies in complex traits显示文摘 | Fu J Festen EA Wijmenga C | 2011 | Hum Mol Genet2011，20，2： | 1 |
| 15 | The prevahaee of Helieohacter pylori in peptic ulcerdi显示文摘 | Kuipe.Thijs C Festen HPM | | 0，，02： | 1 |
| 16 | Tprevalence of Helicobacter pylori in peptic ulcer disease 显示文摘 | Kuipes E J Thijs I C Festen H P M | 1995 | Aliment Pharmacol Ther1995，9，2： | 1 |
| 17 | The prevalence of Helicobaeter pylori in peptic ulcer disease显示文摘 | Kuiper EJ Thijs C Festen HPM | 1995 | Aliment Pharmaeol Ther1995，9，2： | 1 |
| 18 | Postoperative small bowel obstruction in infants and children 显示文摘 | Festen C | 1982 | Ann Surg1982，196，5： | 1 |
| 19 | Giant lymphoma显示文摘 | Festen C Flendrig JA Schillings PH | 1969 | Ned Tijdsehr Geneeskd1969，25，10： | 1 |
| 20 | Pharmacological management of gastro-oesophageal reflux disease显示文摘 | Klinkenberg K E C Festen H P Meuwissen S G | 1995 | Drugs1995，49，5： | 1 |
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