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| 1 | Rapid determina- tion of polyether marine toxins using liquid chromatogra- phy-multiple tandem mass spectrometry显示文摘 | PATRICIA FERN'ANDEZ PUENTE MAR'IA JOS'E FIDALGO S'AEZ BRETT HAMILTON | 2004 | Journal of Chromatography2004，1056，： | 1 |
| 2 | Serotonin: from top to bottom 显示文摘 | Fidalgo S Ivanov DK Wood SH | 2013 | Biogerontology2013，14，1： | 1 |
| 3 | Detection of Mutations in Mismatch Repair Genes in Protuguese Families with Heredatary Non-polyposis Colcrectal Cancer by a Multi-method Approach显示文摘 | Fidalgo P Almenda M R West S | 2008 | Eur J Jum Gene2008，8，： | 1 |
| 4 | Effect of high- pressure pre- treatments on enzymatic activities of Atlantic mackerel( Scomber scombrus ) during frozen storage 显示文摘 | Fidalgo L G Saraiva J A Aubourg S P | 2014 | Innovative Food Science & Emerging Technologies2014，23，6： | 1 |
| 5 | Surface-induced droplet fusion in microfluidic devices显示文摘 | Fidalgo L M Abell C Huck W T S | 2007 | Lab Chip2007，7，： | 1 |
| 6 | A study of a microstructure-dependent composite laminated Timoshenko beam using a modified couple stress theory and a meshless method显示文摘 | Roque C M C Fidalgo D S Ferreira A J M Reddy J N | 2013 | Composite Structures2013，96，0： | 1 |
| 7 | New pharmacological perspective and therapeutic of PPAR -γ agonists显示文摘 | Alarcon de la Lastra C Sanchez - Fidalgo S Villegas I | 2004 | Curr Pharm Des2004，10，28： | 1 |
| 8 | Hybrid silica/polymer aerogals dried at ambient pressure 显示文摘 | Fidalgo A F arinha J P S Martinho J M G | 2007 | Chemistry of Materials2007，19，10： | 1 |
| 9 | Detection of mutationsin mismatch repair genes in portuguese families with hereditarynon-polyposis colorectal cancer(HNPCC)by a multi-method ap-proach显示文摘 | Fidalgo P Almeida MR West S | 2000 | Eur J Hum Genet2000，8，1： | 1 |
| 10 | Dexmedetomidine attenuates isoflurane-induced neurocogni- rive impairment in neonatal rats 显示文摘 | Sanders RD Xu J Shu Y Januszewski A Halder S Fidalgo A | 2009 | Anesthesiology2009，110，5： | 1 |
| 11 | The urban heat island in Salamanca(Spain)and its relationship to meteorological parameters显示文摘 | Alonso M S Fidalgo M R Labajo J L | 2007 | Climate Research2007，34，： | 1 |
| 12 | 显示文摘 | Fidalgo A Farinha J P S | 2007 | Chem Marer2007，19，： | 1 |
| 13 | Endoscopic mucosal resec-tion of superficial colorectal neoplasms : review of 140 procedures显示文摘 | Serrano M M3o de Ferro S Fidalgo P | 2012 | ActaMed Port2012，25，5： | 1 |
| 14 | Effect of high- pressure pre-trealments on enzymatic activities of At|antic mackerel (Scomberscombrus) during frozen storage 显示文摘 | Fidalgo L G Saraiva J A Aubourg S P | 2014 | Inno- vative Food Science g Emerging Technologies2014，23，6： | 1 |
| 15 | A study of a microstructure-dependent composite laminated Timoshenko beam using a modified couple stress theory and a meshless method显示文摘 | ROQUE C M C FIDALGO D S FERREIRA A J M | 2013 | Composite Structures2013，96，4： | 1 |
| 16 | Climate Changes in Brazil: the Expected Financial Benefits by Implementing Smart Grids as a Mitigation and Adaptation Strategy显示文摘 | Débora de Sāo José José Ntmo Fidalgo | 2017 | Journal of Environmental Science and Engineering(B)2017，6，10： | 0 |
| 17 | Septic shock 3.0 criteria application in severe COVID-19 patients:An unattended sepsis population with high mortality risk显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)can be associated with life-threatening organ dysfunction due to septic shock,frequently requiring intensive care unit(ICU)admission,respi-ratory and vasopressor support.There-fore,clear clinical criteria are pivotal for early recognition of patients more likely to need prompt organ support.Although most patients with severe COVID-19 meet the Sepsis-3.0 criteria for septic shock,it has been increasingly recognized that hyperlactatemia is frequently absent,possibly leading to an underestimation of illness severity and mortality risk.AIM To identify the proportion of severe COVID-19 patients with vasopressor support requirements,with and without hyperlactatemia,and describe their clinical outcomes and mortality METHODS We performed a single-center prospective cohort study.All adult patients admitted to the ICU with COVID-19 were included in the analysis and were further divided into three groups:Sepsis group,without both criteria;Vasoplegic Shock group,with persistent hypotension and vasopressor support without hyperlactatemia;and Septic Shock 3.0 group,with both criteria.COVID-19 was diagnosed using clinical and radiologic criteria with a severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)positive RT-PCR test.RESULTS 118 patients(mean age 63 years,87%males)were included in the analysis(n=51 Sepsis group,n=26 Vasoplegic Shock group,and n=41 Septic Shock 3.0 group).SOFA score at ICU admission and ICU length of stay were different between the groups(P<0.001).Mortality was significantly higher in the Vasoplegic Shock and Septic Shock 3.0 groups when compared with the Sepsis group(P<0.001)without a significant difference between the former two groups(P=0.713).The log rank tests of Kaplan-Meier survival curves were also different(P=0.007).Ventilator-free days and vasopressor-free days were different between the Sepsis vs Vasoplegic Shock and Septic Shock 3.0 groups(both P<0.001),and similar in the last two groups(P=0.128 and P=0.133,respectively).Logistic regression identified the maximum dose of vasopressor therapy used(AOR 1.046;95%CI:1.012-1.082,P=0.008)and serum lactate level(AOR 1.542;95%CI:1.055-2.255,P=0.02)as the major explanatory variables of mortality rates(R20.79).CONCLUSION In severe COVID-19 patients,the Sepsis 3.0 criteria of septic shock may exclude approximately one third of patients with a similarly high risk of a poor outcome and mortality rate,which should be equally addressed. | JoséPedro Cidade LM Coelho Vasco Costa Rui Morais Patrícia Moniz Luís Morais Pedro Fidalgo António Tralhão Carolina Paulino David Nora Bernardino Valério Vítor Mendes Camila Tapadinhas Pedro Povoa | 2022 | World Journal of Critical Care Medicine2022，11，4： | 0 |
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