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| 1 | Neurotrophic and metabotrophic potential of nerve growth factor and brain-derived neurotrophic factor: Linking cardiometabolic and neuropsychiatric diseases显示文摘One of biggest recent achievements of neurobiology is the study on neurotrophic factors. The neurotrophins are exciting examples of these factors. They belong to a family of proteins consisting of nerve growth factor(NGF), brain-derived neurotrophic factor(BDNF), neurotrophin-3(NT-3), NT-4/5, NT-6, and NT-7. Today, NGF and BDNF are well recognized to mediate a dizzying number of trophobiological effects, ranging from neurotrophic through immunotrophic and epitheliotrophic to metabotrophic effects. These are implicated in the pathogenesis of various diseases. In the same vein, recent studies in adipobiology reveal that this tissue is the body's largest endocrine and paracrine organ producing multiple signaling proteins collectively termed adipokines, with NGF and BDNF being also produced from adipose tissue. Altogether, neurobiology and adipobiology contribute to the improvement of our knowledge on diseases beyond obesity such as cardiometabolic(atherosclerosis, type 2 diabetes, and metabolic syndrome) and neuropsychiatric(e.g., Alzheimer's disease and depression) diseases. The present review updates evidence for(1) neurotrophic and metabotrophic potentials of NGF and BDNF linking the pathogenesis of these diseases, and(2) NGF- and BDNF-mediated effects in ampakines, NMDA receptor antagonists, antidepressants, selective deacetylase inhibitors, statins, peroxisome proliferator-activated receptor gamma agonists, and purinergic P2X3 receptor up-regulation. This may help to construct a novel paradigm in the field of translational pharmacology of neuro-metabotrophins, particularly NGF and BDNF. | Stanislav Yanev Luigi Aloe Marco Fiore George N Chaldakov | 2013 | World Journal of Pharmacology2013，2，4： | 2 |
| 2 | A hisher incidellce of intermit-tent hypoxemie episodes is associated with severe retinopathy of pre-maturity显示文摘 | Di Fiore J M Bloom J N Orge F et a1 | 2010 | J Pediatr2010，157，1： | 1 |
| 3 | Immature myeloid and plasmacytoid dendritic cells infiltrate renal tubulointemtitium in pa- tients with lupus nephritis 显示文摘 | Fiore N Castellano G Blasi A | 2008 | Mol Immunol2008，45，1： | 1 |
| 4 | Superior mesenteric artery blood flow modifications during off-pump coronary surgery显示文摘 | Fiore G Brienza N Cicala P | 2006 | Ann Thorac Surg2006，82，1： | 1 |
| 5 | Dexamethasone, beta- estradlol, and 2, 3, 7, 8- rCDD elicit thymic atrophy through different cellular Largets显示文摘 | -ilverstone A E Frazier D E J Fiore N | 1994 | Toxicol Appl Pharmaco1994，126，2： | 1 |
| 6 | Hydrogen evolution on nickel incorporated in three-dimensional conducting polymer layers显示文摘 | Fiores E N Omanovic S | 2005 | Journal of Molecular Catalysis A: Chemical2005，242，： | 1 |
| 7 | Rotavirus genotypes co-circulating in Europe between 2006 and 2009 as determined by EuroRotaNet, a pan- European collaborative strain surveillance network显示文摘 | Iturriza-Gomara M Dallman T Banyai K Bottiger B Buesa J Diedrich S Fiore L Johansen K Koopmans M Korsun N Koukou D Kroneman A Laszlo B Lappa- lainen M Maunula L Marques A M Matthijnssens J Midgley S Mladenova Z Nawaz S Poljsak-Prijatelj M Pothier P Ruggeri F M Sanchez-Fauquier A Steyer A Sidaraviciute-Ivaskeviciene I Syriopoulou V Tran A N Usonis V VAN Ranst M DE Rougemont A Gray J | 2011 | Epidemiol Infect2011，139，6： | 1 |
| 8 | Rotavirus surveillance in Europe, 2005-2008: web-enabled repor- ting and real-time analysis of genotyping and epidemio- logical data显示文摘 | Iturriza-Gomara M Dallman T Banyai K Bottiger B Buesa J Diedrich S Fiore L Johansen K Korsun N Kroneman A Lappalainen M Laszlo B Maunula L Mat thinjnssens J Midgley S Mladenova Z Poljsak-Prijatelj M Pothier P Ruggeri F M Sanchez-Fauquier A Schreier E Steyer A Sidaraviciute I Tran A N Usonis V Van Ranst M de Rougemont A Gray J | 2009 | J Infect Dis2009，2001，： | 1 |
| 9 | Right ventricular myocardial functional in ARF patients: PEEP as a challenge for the right heart 显示文摘 | Dambrosio M Fiore C Brienza N | 1996 | Intensive Care Med1996，22，8： | 1 |
| 10 | Superior mesenteric artery blood flow modifications during off-pump coronary surgery显示文摘 | Fiore G Brienza N Cicala P | 2006 | Ann Thorac Surg2006，82，1： | 1 |
| 11 | Photodynamic therapy with vertepofin combined with intravitreal injection of bevacizumab for occult and classic CNV in AMD 显示文摘 | Maier M Haas K Feucht N Fiore B Winkler von Mohrenfels C Clos A | 2008 | Klin Monbl Augenheilkd2008，225，7： | 1 |
| 12 | Ma- pping a research agenda for the science of team science 显示文摘 | Falk-Krzesinski H J Contractor N Fiore S M | 2011 | Research Evaluation2011，20，2： | 1 |
| 13 | Right ventricular myocardial function in ARF patients:PEEP as a challenge for the right heart显示文摘 | Dambrosio M Fiore G Brienza N | 1996 | Intensive Care Med1996，22，8： | 1 |
| 14 | Differential effects of diethylstilbestrol and 2,3,7,8-tetra chlorodibenzo-p-dioxin on thymocyte differentiation,proliferation,and apoptosis in bcl-2 transgenic mouse fetal thymus organ culture显示文摘 | Lai Z W Fiore N C Hahn P J | 2000 | Toxicol Appl Pharmacol2000，168，： | 1 |
| 15 | Nitrogen fixation and nitrogen transformations in marine symbioses 显示文摘 | Fiore C L Jarett J K Olson N D | 2010 | Trends in Mi- crobiology2010，18，10： | 1 |
| 16 | Polyketal micro- particles for therapeutic delivery to the lung 显示文摘 | FIORE VF LOFTON MC MURTHY N | 2010 | Biomaterials2010，31，5： | 1 |
| 17 | Impact of the thimerosalcontroversy on hepatitis B vaccine coverage of infants bom towomen of unknown hepatitis B surface antigen status in Michigan显示文摘 | Biroscak BJ Fiore AE Fasano N | 2003 | Pediatrics2003，111，61： | 1 |
| 18 | Abrasive wear in multiphase microstructures显示文摘 | Kosel T H Fiore N F | 1981 | Journal of Materials for Energy Systems1981，3，2： | 1 |
| 19 | Right ventricular myocardial function in ARFpatients:PEEP as a challenge for the right heart显示文摘 | Dambrosio M Fiore G Brienza N | 1996 | Intensivs Care Med1996，22，8： | 1 |
| 20 | Nitrogen fixation and nitrogen transformations in marine symbioses显示文摘 | Fiore C L Jarett J K Olson N D | 2010 | Trends in Microbiology Elsevier Ltd2010，18，10： | 1 |
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