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| 1 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 2 | Gastric cancer in young people under 30 years of age: worse prognosis, or delay in diagnosis?显示文摘 | Horacio N López-Basave Diaz Romero C Alejandro Padilla Rosciano Melchor Ruan J Silvio A. ?amendys-Silva Vela Sarmiento I Ruiz Molina JM Calderillo Ruiz G Flavia Morales-Vásquez Abelardo Meneses Garcia Angel Herrera-Gomez | 2013 | Cancer Management and Research (default)2013，，： | 2 |
| 3 | Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a post translational mechanism显示文摘 | Mashukova A Flavia A Pedro J | 2011 | Mol Cell Biol2011，31，4： | 1 |
| 4 | Global health 2035: a world converging within a generation显示文摘 | Dean T Jamison Lawrence H Summers George Alleyne Kenneth J Arrow Seth Berkley Agnes Binagwaho Flavia Bustreo David Evans Richard G A Feachem Julio Frenk Gargee Ghosh Sue J Goldie Yan Guo Sanjeev Gupta Richard Horton Margaret E Kruk Adel Mahmoud Linah K Mo | 2013 | 2013 (9908)2013，，9908： | 1 |
| 5 | A Comparative Study of Diesel Analysis by FTIR,FTNIR and FT-Raman Spectroscopy Using PLS and Arti-ficial Neural Network Analysis显示文摘 | Vianney O S J Flavia C C O Daniella G L | 2005 | Analytica Chimica Acta2005，547，2： | 1 |
| 6 | Subcapsular urinoma : an unusual form of page kidney in a high school wrestler 显示文摘 | Brian RM Joseph AV Flavia J | 2002 | J Urol2002，168，2： | 1 |
| 7 | Psychosocial adjustment to orthotopic liver transplantation in 266 recipients显示文摘 | BLANCH J SUREDA B FLAVIA M | 2004 | Liver Transpl2004，10，2： | 1 |
| 8 | Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a post translational mechanism显示文摘 | Mashukova A Flavia A Pedro J | 2011 | Mol Cell Biol2011，31，4： | 1 |
| 9 | T2 hyperintensity along the cortico-spinal tract in cirrhosis relates to functional abnormalities 显示文摘 | Cordoba J Raguer N Flavia M | 2003 | Hepatology2003，38，4： | 1 |
| 10 | Subcapsular urinoma: An unusual form of page kidney in a high school wrestler显示文摘 | Brian R M Joseph A V Flavia J | 2002 | J Urol2002，168，2： | 1 |
| 11 | Rotordynamic force prediction of centrifugal compressor impellers using computational fluid dynamics 显示文摘 | Moore J J Ransom D L Flavia Viana | 2011 | ASME Journal of Engineering for Gas Turbines and Power2011，133，04： | 1 |
| 12 | Highly active heterogeneous Fenton-like systems based on FeO/Fe3O4 composites prepared by controlled reduction of iron oxides显示文摘 | Costa RC C Flavia C C M Ardisson J D | | 0，，： | 1 |
| 13 | Dimethyl adipate hydrogenation at presence of Pt based catalysts显示文摘 | Flavia C A F Elizabete J Wagner A C | 2005 | Catalysis Today2005，，： | 1 |
| 14 | Psychosocial adjustment to orthotopic liver transplantation in 266 recipients 显示文摘 | Blanch J Sureda B Flavia M | 2004 | Liver Transpl2004，10，2： | 1 |
| 15 | Gastric cancer in young people under 30 years of age: worse prognosis, or delay in diagnosis?显示文摘 | Horacio N López-Basave Diaz Romero C Alejandro Padilla Rosciano Melchor Ruan J Silvio A. ?amendys-Silva Vela Sarmiento I Ruiz Molina JM Calderillo Ruiz G Flavia Morales-Vásquez Abelardo Meneses Garcia Angel Herrera-Gomez | 2013 | 2013 (defa)2013，，： | 1 |
| 16 | Psychosocial adjustment to orthotopic liver transplantation in 266 recipients显示文摘 | Blanch J Sureda B Flavia M et a l | 2004 | Liver Transpl2004，10，2： | 1 |
| 17 | Physicochemical and nutritional properties of pigmented rice subjected to different degrees of milling 显示文摘 | Flavia Fernandes Paiva Vanier N L Berrios J D J | 2014 | Journal of Food Composition & Analysis2014，35，1： | 1 |
| 18 | Influence of partial sub- stitution of dietary fish meal on the activity of digestive enzymes inthe intestinal brush border membrane of gilthead sea bream, Sparus aurata and goldfish, Carassius auratus 显示文摘 | Flavia C P Silva J R Nicoli J L | 2010 | Aquaculture2010，30，6： | 1 |
| 19 | T'2 hyperintensity along the cortico-spinal tract in cirrhosis relates to functional abnormalities显示文摘 | Cordoba J Raguer N Flavia M | 2003 | Hepatology2003，38，4： | 1 |
| 20 | Global health 2035: a world converging within a generation显示文摘 | Dean T Jamison Lawrence H Summers George Alleyne Kenneth J Arrow Seth Berkley Agnes Binagwaho Flavia Bustreo David Evans Richard G A Feachem Julio Frenk Gargee Ghosh Sue J Goldie Yan Guo Sanjeev Gupta Richard Horton Margaret E Kruk Adel Mahmoud Linah K Mo | 2013 | The Lancet . 2013 (9908)2013，，： | 1 |
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