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| 1 | 内镜下射频消融术治疗范围广泛的0-Ⅱb型早期食管鳞状细胞癌及癌前病变的临床效果显示文摘目的探讨内镜下应用HALO射频消融系统(Radiofrequency Ablation,RFA)治疗范围广泛的早期表浅平坦型(0-Ⅱb)食管鳞状细胞癌及癌前病变的治疗效果。方法对中国医学科学院肿瘤医院自2008年10月至2011年6月应用HALO射频消融系统治疗的33例早期食管鳞状细胞癌(early esophageal squamous cell cancer,EESCC)、重度不典型增生(high grade dysplasia,HGD)及中度不典型增生(middle grade dysplasia,MGD)患者的临床资料进行分析,观察治疗后1年病变组织学上完全缓解率(CR)及并发症情况。结果33例患者中,男26例,女7例,年龄平均61岁,MGD10例,HGD17例,EESCC6例,病变长度3~12(平均7.9)cm,治疗区域长度5~14(平均9.9)cm,累及食管周径平均11/12周。33例患者首次治疗手术时间11~57(平均30)min,平均住院时间3天。首次治疗后3个月内镜随访CR达69.7%(23/33),随访期间追加治疗1—4(平均2.7)次,12个月内镜随访时CR达93.9%(31/33)。4例(12%)术后出现重度狭窄,行内镜下水囊扩张术3—12(平均7)次,扩张后均缓解。无其他并发症发生。结论RFA治疗范围广泛的0-Ⅱb型早期食管鳞状细胞癌和癌前病变是安全的、有效的且是一项对于操作者技术要求较低的技术,扩大了内镜微创治疗的适应证。 | 张月明 贺舜 吕宁 薛丽燕 David E Fleischer Bas Weusten Sanford M Dawsey 窦利州 Jacques JGHM Bergman 王贵齐 | 2015 | 中华消化内镜杂志2015,32,9: | 8 |
| 2 | 内镜下射频消融术联合内镜黏膜切除术治疗大面积非表浅平坦型早期食管鳞状细胞癌和癌前病变疗效初探显示文摘目的:探讨内镜下联合应用射频消融系统(RFA)和内镜下黏膜切除术治疗范围广泛的非表浅平坦型早期食管鳞状细胞癌及癌前病变的治疗效果。方法北京协和医学院中国医学科学院肿瘤医院内镜科于2010年1月对经活检病理确诊的2例鳞状细胞癌、1例鳞状上皮中度不典型增生(MGIN)和1例鳞状上皮重度不典型增生(HGIN)患者予以内镜下RFA术联合内镜黏膜切除术治疗,总结分析术中、术后和随访情况。结果4例患者均顺利完成治疗,其中RFA时间为3~12(8.3) min,内镜下黏膜切除术时间6~20(10.3) min;所有病例均无出血和穿孔的发生。2例鳞状细胞癌患者病变长度分别为12和8 cm,非表浅平坦性病变长度分别为3和4 cm;MGIN患者的病变长度6 cm ,非表浅平坦性病变长度2 cm;HGIN患者的病变长度12 cm ,非表浅平坦型病变长度1 cm;术后病理与术前活检病理一致。4例术后均出现狭窄,其中2例为轻度狭窄,未予处理;2例为重度狭窄,行内镜下水囊扩张术均缓解。平均住院时间3d。3例经过3月及1年以上随访,治疗区域活检病理均达到完全缓解;余1例术后3月复查可见散在的碘染色阳性灶,活检病理为HGIN,分别追加RFA治疗后达到完全缓解。结论 RFA联合内镜下黏膜切除术治疗大面积非表浅平坦型早期食管鳞状细胞癌和癌前病变是安全有效的。 | 张月明 JacquesJGHMBergman 薛丽燕 贺舜 吕宁 David E Fleischer Bas Weusten Sanford M Dawsey 窦利州 王贵齐 | 2015 | 中华胃肠外科杂志2015,18,9: | 7 |
| 3 | Nonvaricel upper gastrointestinal bleeding an update 显示文摘 | Rollhauser C Fleischer D E | 1997 | ENDOSCOPY1997,29,2: | 1 |
| 4 | 查看详情显示文摘 | Fleischer E B Palmer J M Srivastava T S | | 0,,: | 1 |
| 5 | A prospective study of the utility of abdominal radiographs after capsule endoscopy for the diagnosis of capsule retention 显示文摘 | Sachdev M S Leighton J A Fleischer D E | 2007 | Gastrointest Endosc2007,66,5: | 1 |
| 6 | Sensor placement in municipal water networks 显示文摘 | Jonathan W Berry Lisa Fleischer William E Hart | 2005 | J Water Resour Plan Manage2005,131,3: | 1 |
| 7 | Esophageal cancer: epidemiology, pathogenesis and prevention显示文摘 | Sarah B Umar David E Fleischer | 2008 | Nat Clin Pratt Gastroenterol Hepatol2008,5,9: | 1 |
| 8 | Esophageal cancer:epidemiology,pathogenesis and prevention显示文摘 | UMAR S B FLEISCHER D E | 2008 | Nat Clin Pract Gastroenterol Hepatol2008,5,9: | 1 |
| 9 | Sensor placement in municipal water networks显示文摘 | Fleischer L Hart W E | 2005 | Journal of Water Resources Planning and Management2005,131,3: | 1 |
| 10 | X-ray structure determination of cubane显示文摘 | Fleischer E B | 1964 | J Am Chem Soc1964,86,18: | 1 |
| 11 | Endoscopic laser therapy for esophageal cancer显示文摘 | HADDAD N G FLEISCHER D E | 1994 | Gastrointest Endosc Clin N Am1994,4,4: | 1 |
| 12 | Mechanical module interfaces for reconfigurable machine tools 显示文摘 | Abele E Worn A Fleischer J | 2007 | Product Engineering2007,1,4: | 1 |
| 13 | Phosphodiesterase inhibitor pentoxifylline, a selective suppressor of T helper type 1 - but not type 2 - associated lymphokine production, prevents induction of experimental autoimmune encephalomyelitis in Lewis rats 显示文摘 | Rott O Cash E Fleischer B | 1993 | Eur J Immunol1993,23,8: | 1 |
| 14 | Synchronous techniques for timing recovery in BISDN显示文摘 | LAU R C FLEISCHER P E | 1995 | IEEE Transaction on Communications1995,43,: | 1 |
| 15 | Sensor placement in mu- nicipal water networks显示文摘 | Berry J W Fleischer L Hart W E | 2005 | Journal of Water Resources Planning and Management2005,131,3: | 1 |
| 16 | Nonvariceal upper gastrointestinal ble - eding: an update 显示文摘 | Rollhauser C Fleischer D E | 1997 | Endoscopy1997,29,2: | 1 |
| 17 | Mucosal lodine staining improves endoscopic visualization of squamous dysplasia and squamous cell carcinoma of the esophagus in Linxian,China显示文摘 | Dawsey S M Fleischer D E Wang G Q | 1998 | Cancer1998,83,: | 1 |
| 18 | Expression of the G glycoprotein gene of human respiratory syncytial virus in Salmonella typhimurium显示文摘 | Martin-Gallardo A Fleischer E Doyle S A | 1993 | J Gen Virol1993,74,3: | 1 |
| 19 | Genetic analyses through DNA fingerprinting of captive population of Hawaiian geese 显示文摘 | Rave E H Fleischer R C Duvall F | 1994 | Conservation Biology1994,8,3: | 1 |
| 20 | Coordination oligomers and a coordination polymer of zinc tetraarylporphyrins 显示文摘 | Fleischer E B Shachter A M | 1991 | Inorganic Chemistry1991,30,19: | 1 |