9篇
您的检索式：作者名="Fleming LE"
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| 1 | 显示文摘 | Fleming LE | 2002 | Harmful Algal2002，1，： | 1 |
| 2 | Neuropsychologic effects inchronic ciguatera fish poisoning 显示文摘 | ArenaP Levin B Fleming LE | 2004 | Harmful Algae2004，3，1： | 1 |
| 3 | A mass balance approach for evaluating leachable arsenic and chromium from an in-service CCA-treated wood structure显示文摘 | Shibata T Solo-Gabriele HM Fleming LE | 2007 | Sci Total Environ2007，372，23： | 1 |
| 4 | 显示文摘 | Fleming LE | 2002 | Harm Algae2002，7，： | 1 |
| 5 | Pulmonary lymphangioleiomyomatosis (LAM):examining oral contraceptive pills and the onset of disease显示文摘 | Oberstein EM Fleming LE Gomez-Marin O | | 0，，： | 1 |
| 6 | The ABC transporter SpTUR2 confers resistance to the antifungal diterpene sclareol 显示文摘 | van den Brle Sybille Müller Axel Fleming Andrew J | 2002 | Plant Journal2002，30，6： | 1 |
| 7 | 显示文摘 | Fleming LE | 2002 | Harmful Algae2002，1，2： | 1 |
| 8 | Oceans and human health: emerging public health risks in the marine environment 显示文摘 | Fleming LE Broad K Clement A | 2006 | Mar Pollut Bull2006，53，1012： | 1 |
| 9 | Spinal cord injury reprograms muscle fibroadipogenic progenitors to form heterotopic bones within muscles显示文摘The cells of origin of neurogenic heterotopic ossifications(NHOs), which develop frequently in the periarticular muscles following spinal cord injuries(SCIs) and traumatic brain injuries, remain unclear because skeletal muscle harbors two progenitor cell populations: satellite cells(SCs), which are myogenic, and fibroadipogenic progenitors(FAPs), which are mesenchymal. Lineage-tracing experiments using the Cre recombinase/Lox P system were performed in two mouse strains with the fluorescent protein Zs Green specifically expressed in either SCs or FAPs in skeletal muscles under the control of the Pax7 or Prrx1 gene promoter, respectively. These experiments demonstrate that following muscle injury, SCI causes the upregulation of PDGFRα expression on FAPs but not SCs and the failure of SCs to regenerate myofibers in the injured muscle, with reduced apoptosis and continued proliferation of muscle resident FAPs enabling their osteogenic differentiation into NHOs. No cells expressing Zs Green under the Prrx1 promoter were detected in the blood after injury, suggesting that the cells of origin of NHOs are locally derived from the injured muscle. We validated these findings using human NHO biopsies. PDGFRα+mesenchymal cells isolated from the muscle surrounding NHO biopsies could develop ectopic human bones when transplanted into immunocompromised mice, whereas CD56+myogenic cells had a much lower potential. Therefore, NHO is a pathology of the injured muscle in which SCI reprograms FAPs to undergo uncontrolled proliferation and differentiation into osteoblasts. | Hsu-Wen Tseng Dorothée Girard Kylie A.Alexander Susan M.Millard Frédéric Torossian Adrienne Anginot Whitney Fleming Jules Gueguen Marie-Emmanuelle Goriot Denis Clay Beulah Jose Bianca Nowlan Allison R.Pettit Marjorie Salga François Genêt Marie-Caroline Le Bousse-Kerdilès Sébastien Banzet Jean-Pierre Lévesque | 2022 | Bone Research2022，10，2： | 0 |
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