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| 1 | Basement membrane and repair of injury to peripheral nerve:defining a potential role for macrophages,matrix metalloproteinases,and tissue inhibitor of metalloproteinases1显示文摘 | La Fleur M Underwood J L Rappolee D A | 1996 | J Exp Med1996，184，6： | 1 |
| 2 | Anti-obesity drugs and neural circuits of feeding显示文摘 | Roger A H Adan Louk J M J.Vanderschuren Susanne E.la Fleur | | 0，，04： | 1 |
| 3 | Effect of sowing season, sowing rate and soil type显示文摘 | Hitchmough J de la Fleur M Find]ay C Estab- lishing North American prairie vegetation in urban parks in northern England:Part 1 | 2004 | Landscape and ur- ban planning2004，66，： | 1 |
| 4 | Establishing North American prairie vegetation in uran parks in northern Englang:Effect of management and soil type on long-term community development显示文摘 | Hitchmough J D Fleur M | 2006 | Landscape and Urban Planning2006，78，： | 1 |
| 5 | Team development and group processes of virtual learning teams 显示文摘 | Johnson S D Suriya C Won Yoon S Berrett J V La Fleur J | 2002 | Computers and Education2002，39，4： | 1 |
| 6 | Establishing North American prairie vegetation in urban parks in northern England: Effect of management and soil type on long-term community development 显示文摘 | Hitchmough J De la Fleur M | 2006 | Landscape and urban plan ning2006，78，： | 1 |
| 7 | The suprachiasmatic nucleus balances sympathetic and parasympathetic output to peripheral organs through separate preautonomic neurons显示文摘 | Buijs RM la Fleur SE Wortel J | 2003 | J Comp Neurol2003，464，1： | 1 |
| 8 | Establishing north American prairie vegetation in urban parks in northern England:Effect of management and soil type on long-term community development显示文摘 | Hitchmough J Marcus de la Fleur | | 0，，： | 1 |
| 9 | Tyrosine kinase inhibitors:Multi-targeted or single-targeted?显示文摘Since in most tumors multiple signaling pathways are involved,many of the inhibitors in clinical development are designed to affect a wide range of targeted kinases.The most important tyrosine kinase families in the development of tyrosine kinase inhibitors are the ABL,SCR,platelet derived growth factor,vascular endothelial growth factor receptor and epidermal growth factor receptor families.Both multi-kinase inhibitors and singlekinase inhibitors have advantages and disadvantages,which are related to potential resistance mechanisms,pharmacokinetics,selectivity and tumor environment.In different malignancies various tyrosine kinases are mutated or overexpressed and several resistance mechanisms exist.Pharmacokinetics is influenced by interindividual differences and differs for two single targeted inhibitors or between patients treated by the same tyrosine kinase inhibitor.Different tyrosine kinase inhibitors have various mechanisms to achieve selectivity,while differences in gene expression exist between tumor and stromal cells.Considering these aspects,one type of inhibitor can generally not be preferred above the other,but will depend on the specific genetic constitution of the patient and the tumor,allowing personalized therapy.The most effective way of cancer treatment by using tyrosine kinase inhibitors is to consider each patient/tumor individually and to determine the strategy that specifically targets the consequences of altered(epi)genetics of the tumor.This strategy might result in treatment by a single multi kinase inhibitor for one patient,but in treatment by a couple of single kinase inhibitors for other patients. | Fleur Broekman Elisa Giovannetti Godefridus J Peters | 2011 | World Journal of Clinical Oncology2011，2，2： | 1 |
| 10 | Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: differential role for PD-L1 显示文摘 | WENDY W J SANDRA L FLEUR K S | 2009 | European Journal of Immunology2009，39，11： | 1 |
| 11 | The use of co-solvents in supercritical debinding of ceramics 显示文摘 | Fleur B Thierry C Baumard J F | 2002 | Journal of the European Ceramic Society2002，22，： | 1 |
| 12 | Early in intensive therapy with au-tologous stem cell transplantation in advanced Hodgkin's disease retro-spective analysis of 158 cases from the French registry显示文摘 | Morean P Fleure J Brice P | 1998 | Bone Marrow Transplant1998，21，： | 1 |
| 13 | Collagenase-3 (MMP-13) in fetal membranes and amniotic fluid during pregnancy显示文摘 | Fortunato S J La Fleur B Menon R | 2003 | Am J Reprod Immunol2003，49，2： | 1 |
| 14 | Diagnostic performance of 320-slice multidetector computed tomography coronary angiography in patients aftercoronary artery bypass grafting显示文摘 | Fleur RG Joella EV Agnieszka J | 2011 | Eur Radiol2011，21，： | 1 |
| 15 | Role for the pineal and melatonin in glucose homeostasis:pinealectomy increases night-time glucose concentrations显示文摘 | FLEUR S E KALSBE A WORTEL J | 2001 | Neuroendocrinol2001，13，： | 1 |
| 16 | Establishing North American Prairie vegetation in urban parks in northern England: Effect of management practice and initial soil type on long term community development显示文摘 | Hitchmough J D De La Fleur M | 2006 | Landscape and Urban Planning2006，，78： | 1 |
| 17 | Phase separation in Cu43Zr43Al7Ag7 bulk metallic glass显示文摘 | OH J C OHKUBO T KIM Y C FLEUR Y E HONO K | | 0，，： | 1 |
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