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| 1 | Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells显示文摘Mesenchymal stem cells(MSCs)are promising candidates for bone regeneration therapies due to their plasticity and easiness of sourcing.MSC-based treatments are generally considered a safe procedure,however,the long-term results obtained up to now are far from satisfactory.The main causes of these therapeutic limitations are inefficient homing,engraftment,and osteogenic differentiation.Many studies have proposed modifications to improve MSC engraftment and osteogenic differentiation of the transplanted cells.Several strategies are aimed to improve cell resistance to the hostile microenvironment found in the recipient tissue and increase cell survival after transplantation.These strategies could range from a simple modification of the culture conditions,known as cell-preconditioning,to the genetic modification of the cells to avoid cellular senescence.Many efforts have also been done in order to enhance the osteogenic potential of the transplanted cells and induce bone formation,mainly by the use of bioactive or biomimetic scaffolds,although alternative approaches will also be discussed.This review aims to summarize several of the most recent approaches,providing an up-to-date view of the main developments in MSCbased regenerative techniques. | Daniel García-Sánchez Darío Fernández JoséC Rodríguez-Rey Flor M Pérez-Campo | 2019 | World Journal of Stem Cells2019，11，10： | 4 |
| 2 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 3 | Mesenchymal stem cells secretome:The cornerstone of cell-free regenerative medicine显示文摘Mesenchymal stem cells(MSCs)are the most frequently used stem cells in clinical trials due to their easy isolation from various adult tissues,their ability of homing to injury sites and their potential to differentiate into multiple cell types.However,the realization that the beneficial effect of MSCs relies mainly on their paracrine action,rather than on their engraftment in the recipient tissue and subsequent differentiation,has opened the way to cell-free therapeutic strategies in regenerative medicine.All the soluble factors and vesicles secreted by MSCs are commonly known as secretome.MSCs secretome has a key role in cell-to-cell communication and has been proven to be an active mediator of immunemodulation and regeneration both in vitro and in vivo.Moreover,the use of secretome has key advantages over cell-based therapies,such as a lower immunogenicity and easy production,handling and storage.Importantly,MSCs can be modulated to alter their secretome composition to better suit specific therapeutic goals,thus,opening a large number of possibilities.Altogether these advantages now place MSCs secretome at the center of an important number of investigations in different clinical contexts,enabling rapid scientific progress in this field. | Alberto González-González Daniel García-Sánchez Monica Dotta JoséC Rodríguez-Rey Flor M Pérez-Campo | 2020 | World Journal of Stem Cells2020，12，12： | 2 |
| 4 | Vertical array growth of small diameter single-walled carbon nanotubes显示文摘 | Xu Y Q Flor E Kim J M | 2006 | Journal of the American Chemical Society2006，128，： | 1 |
| 5 | NdCoO3 perovskite as possible candidate for CO-sensors:thin films synthesis and sensing properties显示文摘 | Malavasi L Tealdi C Flor G Chiodelli G Cervetto V Montenero A Borella M | | 0，，02： | 1 |
| 6 | The influence of firms technological capabilities on export performance in supplier-dominated industries显示文摘 | FLOR M OLTRA M J | 2005 | R&D management2005，25，3： | 1 |
| 7 | Imaging the produc- tion of singlet oxygen in vivo using a new fluorescent sen- sor, Singlet Oxygen Sensor Green 显示文摘 | Flors C Fryer M J Waring J | 2006 | J Exp Bot2006，57，： | 1 |
| 8 | Identification of innovating finns through technological innovation indicators: An application to the Spanish ceramic tile industry 显示文摘 | FLOR M L OLTRA M J | 2004 | Research Policy2004，，33： | 1 |
| 9 | Cataract surgery and quality of life in patients with age related macular degeneration显示文摘 | Lundstrom M Brege KG Flor e n I | 2002 | Br J Ophthalmol2002，86，12： | 1 |
| 10 | Priming:getting ready for battle显示文摘 | Conrath U Beckers G J M Flors V | | 0，，10： | 1 |
| 11 | Prevalence of pertussis antibodies in maternal delivery, cord and infant serum 显示文摘 | CMary Healy Flor M Munoz Marcia A Rench | 2004 | J Infect Dis2004，190，2： | 1 |
| 12 | Effect of reaction time on the particle size of ZnO and ZnO : Ce obtained by a sol-gel method 显示文摘 | FLOR J LIMA S DAVOLOS M | 2004 | Surface and Colloid Science2004，128，： | 1 |
| 13 | Cortical reorganization and phantom phenomena in congenital and traumat/c upper- extremity am-putees 显示文摘 | Flor H Elbert T M hlnickel W | 1998 | Exp Brain Res1998，119，： | 1 |
| 14 | Determinants of growth during gonadotropin-releasing hormone analog therapy for precocious puberty显示文摘 | Weise M Flor A Barnes KM | 2004 | Clin Endocrinol Metab2004，89，1： | 1 |
| 15 | Effect ofsenmry discm'nination training on cortical reorganization and phantom limb pain 显示文摘 | Flor H Denke C Schaefer M | 2001 | Lancet2001，357，： | 1 |
| 16 | Effect of sensory discrimination training on cortical reorganization and phantom limb pain显示文摘 | Flor H Denke C Schaefer M | 2001 | Lancet2001，357，： | 1 |
| 17 | Solving a multi objective location routing problem with a metaheuristic based on tabu search显示文摘 | Caballero R Gonzalez M Flor M G | 2007 | European Journal of Operational Research2007，177，3： | 1 |
| 18 | Regenerative nodules in patients with chronic Budd-Chiari syndrome: A longitudinal study using multi- phase contrast-enhanced multidetector CT 显示文摘 | Flor N Zuin M Brovelli F | 2010 | Eur J Radiol2010，73，3： | 1 |
| 19 | Iron and copper chelation by flavonoids:an electrospray mass spectrometry study显示文摘 | Fernandez M T Mira M L Florêncio M H | | 0，，02： | 1 |
| 20 | Conditionally adherent growth of selllUl-independent CHO cells for automated drug screeningan diopharmaceutical production显示文摘 | Gandor C Zang-Gandor M Flor P | 1999 | Biotechnol Bioeng1999，65，： | 1 |
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