|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells显示文摘Mesenchymal stem cells(MSCs)are promising candidates for bone regeneration therapies due to their plasticity and easiness of sourcing.MSC-based treatments are generally considered a safe procedure,however,the long-term results obtained up to now are far from satisfactory.The main causes of these therapeutic limitations are inefficient homing,engraftment,and osteogenic differentiation.Many studies have proposed modifications to improve MSC engraftment and osteogenic differentiation of the transplanted cells.Several strategies are aimed to improve cell resistance to the hostile microenvironment found in the recipient tissue and increase cell survival after transplantation.These strategies could range from a simple modification of the culture conditions,known as cell-preconditioning,to the genetic modification of the cells to avoid cellular senescence.Many efforts have also been done in order to enhance the osteogenic potential of the transplanted cells and induce bone formation,mainly by the use of bioactive or biomimetic scaffolds,although alternative approaches will also be discussed.This review aims to summarize several of the most recent approaches,providing an up-to-date view of the main developments in MSCbased regenerative techniques. | Daniel García-Sánchez Darío Fernández JoséC Rodríguez-Rey Flor M Pérez-Campo | 2019 | World Journal of Stem Cells2019，11，10： | 4 |
| 2 | Mesenchymal stem cells secretome:The cornerstone of cell-free regenerative medicine显示文摘Mesenchymal stem cells(MSCs)are the most frequently used stem cells in clinical trials due to their easy isolation from various adult tissues,their ability of homing to injury sites and their potential to differentiate into multiple cell types.However,the realization that the beneficial effect of MSCs relies mainly on their paracrine action,rather than on their engraftment in the recipient tissue and subsequent differentiation,has opened the way to cell-free therapeutic strategies in regenerative medicine.All the soluble factors and vesicles secreted by MSCs are commonly known as secretome.MSCs secretome has a key role in cell-to-cell communication and has been proven to be an active mediator of immunemodulation and regeneration both in vitro and in vivo.Moreover,the use of secretome has key advantages over cell-based therapies,such as a lower immunogenicity and easy production,handling and storage.Importantly,MSCs can be modulated to alter their secretome composition to better suit specific therapeutic goals,thus,opening a large number of possibilities.Altogether these advantages now place MSCs secretome at the center of an important number of investigations in different clinical contexts,enabling rapid scientific progress in this field. | Alberto González-González Daniel García-Sánchez Monica Dotta JoséC Rodríguez-Rey Flor M Pérez-Campo | 2020 | World Journal of Stem Cells2020，12，12： | 2 |
| 3 | A Model-View-Controller Extension for Pervasive Multi-client User Interfaces显示文摘 | Sauter P Specht G Flor T | 2005 | Personal Ubiquitous Computing2005，，9： | 1 |
| 4 | Randomized clinical study of polydioxanone and nylon sutures for laparotomy closure in high-risk patients 显示文摘 | DOCOBD F SACRISTAN P C FLOR C B | 2006 | Cir Esp2006，79，5： | 1 |
| 5 | 3D nanoscopy: Bringing biological nanostructures into sharp focus 显示文摘 | Dedecker P Flors C Hotta J | 2007 | Angew Chem Int Ed2007，46，： | 1 |
| 6 | A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing 显示文摘 | Flor P J Flanegan J B Cech T R | 1989 | EMBO J1989，8，11： | 1 |
| 7 | Diversity and Evolution of the Envelope Gene of Dengue Virus Type 1显示文摘 | Ana P Goncalvez Ananias A Escalante Flor H Pujol | 2002 | Virology2002，303，： | 1 |
| 8 | Randomized clinical study of polydioxanone and nylon sutures for laparotomy closure in high-risk patients 显示文摘 | DOCOB D F SACRISTAN P C FLOR C B | 2006 | Cir Esp2006，79，5： | 1 |
| 9 | Conditionally adherent growth of selllUl-independent CHO cells for automated drug screeningan diopharmaceutical production显示文摘 | Gandor C Zang-Gandor M Flor P | 1999 | Biotechnol Bioeng1999，65，： | 1 |
| 10 | Acute pulmonary histoplasmosis in a Spanish traveller to Nicaragua:an imported disease case显示文摘 | Flor A Estivills D Pérez R | 2003 | Rev Iberoam Micol2003，20，1： | 1 |
| 11 | Characterization of the Antirrhinum floral homeotic MADS-box gene deficiens: Evidence for DNA binding and autore-gulation of its persistent expression throughout flower deve-lopment显示文摘 | SCHWARZ-SOMMER Z HUE I HUIJSER P FLOR P J HANSEN R TETENS F LONNING W E SAEDLER H SOMMER H | 1992 | The EMBO Journal1992，11，1： | 1 |
| 12 | A source-imaging ( low- resolution electromagnetic tomography) study of the EEGs from unmedicated males with depression 显示文摘 | Flor - Henry P Lind JC Koles ZJ | 2004 | Psychiatry Res2004，130，2： | 1 |
| 13 | Purification and characterizafion of a xylanase and arabinofuranosidase from Bacillus polymyxa显示文摘 | Morales P Madarro A Flors A | 1995 | Enzyme and Microb Techn1995，17，： | 1 |
| 14 | Endoleak detection after endovaseular repair of thoracic aortic aneurysm using dual- source dual-energy CT: suitable scanning protocols and potential radiation dose reduction显示文摘 | Flors L Leiva-Salinas C Norton P T | 2013 | AJR2013，200，2： | 1 |
| 15 | Constitutively active RhoAinhibits proliferation by retarding G (1) to S phase cell cycle progression and impairing cytokinesis显示文摘 | MORIN P FLORS C OLSON MF | 2009 | Eur J Cell Biol2009，88，9： | 1 |
| 16 | Stable transformants of the azaphilone pigment-producing Monascus purpureus obtained by protoplast transformation and Agrobacterium-mediated DNA transfer显示文摘 | Sonia Campoy Flor Pérez Juan F. Martín Santiago Gutiérrez Paloma Liras | 2003 | Current Genetics2003，，6： | 1 |
| 17 | Metabotropic glutamate receptor 7: At the interface of cognition and emotion显示文摘 | O'Connor R M Finger B C Flor P J | 2010 | European Journal of Pharmacology2010，639，13： | 1 |
| 18 | Prognostic heterogeneity of endosonographic T3 rectal cancer 显示文摘 | EscIapez P Garcia-Granero E Flor B | 2009 | Dis Colon Rectum2009，52，： | 1 |
| 19 | Discovery and characterization of non-competitive antagonists of group I metabotropic glutamate receptors 显示文摘 | Gasparini F Floersheim P Flor PJ | 2001 | Farmaco2001，56，： | 1 |
| 20 | Stable transformants of the azaphilone pigment-producing Monascus purpureus obtained by protoplast transformation and Agrobacterium-mediated DNA transfer显示文摘 | Sonia Campoy Flor Pérez Juan F. Martín Santiago Gutiérrez Paloma Liras | 2003 | Current Genetics2003，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员