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| 1 | Systematic review of colorectal cancer screening guidelines for average-risk adults: Summarizing the current global recommendations显示文摘AIM To summarize and compare worldwide colorectal cancer(CRC) screening recommendations in order to identify similarities and disparities.METHODS A systematic literature search was performed using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge identifying all average-risk CRC screening guideline publications within the last ten years and/or position statements published in the last 2 years. In addition, a hand-search of the webpages of National Gastroenterology Society websites, the National Guideline Clearinghouse, the BMJ Clinical Evidence website,Google and Google Scholar was performed. RESULTS Fifteen guidelines were identified. Six guidelines were published in North America, four in Europe, four in Asia and one from the World Gastroenterology Organization. The majority of guidelines recommend screening average-risk individuals between ages 50 and 75 using colonoscopy(every 10 years), or flexible sigmoidoscopy(FS, every 5 years) or fecal occult blood test(FOBT, mainly the Fecal Immunochemical Test, annually or biennially). Disparities throughout the different guidelines are found relating to the use of colonoscopy, rank order between test, screening intervals and optimal age ranges for screening. CONCLUSION Average risk individuals between 50 and 75 years should undergo CRC screening. Recommendations for optimal surveillance intervals, preferred tests/test cascade as well as the optimal timing when to start and stop screening differ regionally and should be considered for clinical decision making. Furthermore, local resource availability and patient preferences are important to increase CRC screening uptake, as any screening is better than none. | Florence Bénard Alan N Barkun Myriam Martel Daniel von Renteln | 2018 | World Journal of Gastroenterology2018，24，1： | 16 |
| 2 | Matrix metalloproteinase-9 contributes to parenchymal hemorrhage and necrosis in the remnant liver after extended hepatectomy in mice显示文摘AIM:To investigate the effect of matrix metalloproteinase-9(MMP-9) on the remnant liver after massive hepatectomy in the mouse.METHODS:Age-matched,C57BL/6 wild-type(WT),MMP-9(-/-),and tissue inhibitors of metalloproteinases(TIMP)-1(-/-) mice were used.The mice received 80%-partial hepatectomy(PH).Samples were obtained at 6 h after 80%-PH,and we used histology,immunohistochemical staining,western blotting analysis and zymography to investigate the effect of PH on MMP-9.The role of MMP-9 after PH was investigated using a monoclonal antibody and MMP inhibitor.RESULTS:We examined the remnant liver 6 h after 80%-PH and found that MMP-9 deficiency attenuated the formation of hemorrhage and necrosis.There were significantly fewer and smaller hemorrhagic and necrotic lesions in MMP-9(-/-) remnant livers compared with WT and TIMP-1(-/-) livers(P < 0.01),with no difference between WT and TIMP-1(-/-) mice.Serum alanine aminotransaminase levels were significantly lower in MMP-9(-/-) mice compared with those in TIMP-1(-/-) mice(WT:476 ± 83 IU/L,MMP-9(-/-):392 ± 30 IU/L,TIMP-1(-/-):673 ± 73 IU/L,P < 0.01).Western blotting and gelatin zymography demonstrated a lack of MMP-9 expression and activity in MMP-9(-/-) mice,which was in contrast to WT and TIMP-1(-/-) mice.No change in MMP-2 expression was observed in any of the study groups.Similar to MMP-9(-/-) mice,when WT mice were treated with MMP-9 monoclonal antibody or the synthetic inhibitor GM6001,hemorrhagic and necrotic lesions were significantly smaller and fewer than in control mice(P < 0.05).These results suggest that MMP-9 plays an important role in the development of parenchymal hemorrhage and necrosis in the small remnant liver.CONCLUSION:Successful MMP-9 inhibition attenuates the formation of hemorrhage and necrosis and might be a potential therapy to ameliorate liver injury after massive hepatectomy. | Norifumi Ohashi Tomohide Hori Florence Chen Sura Jermanus Christopher B Eckman Akimasa Nakao Shinji Uemoto Justin H Nguyen | 2012 | World Journal of Gastroenterology2012，18，19： | 3 |
| 3 | Prognostic interest of bone turnover markers in the management of postmenopausal osteoporosis显示文摘 | Florence Chopin Emmanuel Biver Thomas Funck-Brentano Béatrice Bouvard Guillaume Coiffier Patrick Garnero Thierry Thomas | 2011 | Joint Bone Spine2011，，1： | 2 |
| 4 | Spend residue from cumin-A potential source of dietary fiber显示文摘 | SOWBHAGYA H B FLORENCE P S | 2007 | Food Chemistry2007，104，： | 1 |
| 5 | Catalytic reduction of nitrate in water on a monometallic Pd/CeO2 Catalyst 显示文摘 | Florence E Florence G Jacques B | 2002 | Journal of Catalysis2002，206，： | 1 |
| 6 | Thermal inactivation and injury of Bacillus stearothermophilus spores显示文摘 | FLORENCE E F DONALD T M DURWOOD B R | 1987 | Applied and Environmental Microbiology1987，53，2： | 1 |
| 7 | Denoising NMR time-domain sig- nal by singular-value decomposition accelerated by graphics processing unites显示文摘 | Pascal P M Christian B Florence B | 2014 | Solid State Nuclear Magnetic Resonance2014，61，5： | 1 |
| 8 | Spent residace from cumin--a potential source of dietary fiber显示文摘 | SOWBHAGYA H B FLORENCE S P MAHADEVAMMA S | 2007 | Food Chemistry2007，，4： | 1 |
| 9 | Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders显示文摘 | Eider M. Arenaza-Urquijo Brigitte Landeau Renaud La Joie Katell Mevel Florence Mézenge Audrey Perrotin Béatrice Desgranges David Bartrés-Faz Francis Eustache Ga?l Chételat | 2013 | Neuroimage2013，，： | 1 |
| 10 | Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition12345显示文摘 | Martine M Ros H Bas Bueno-de-Mesquita Ellen Kampman Katja KH Aben Frederike L Büchner Eugene HJM Jansen Carla H van Gils Lars Egevad Kim Overvad Anne Tj?nneland Nina Roswall Marie Christine Boutron-Ruault Marina Kvaskoff Florence Perquier Rudolf Kaaks Jen | 2012 | American Journal of Clinical Nutrition2012，，4： | 1 |
| 11 | Cerebral Palsy Among Very Preterm Children in Relation to Gestational Age and Neonatal Ultrasound Abnormalities: The EPIPAGE Cohort Study显示文摘 | Pierre- Yves Aneel Florence Livinec B atrice Larroque | 2006 | Pediatrics2006，3，117： | 1 |
| 12 | Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trail):a multicentre randomized controlled trial显示文摘 | Lila B Charles-Edouard L Florence T | 2010 | Lancet2010，375，9713： | 1 |
| 13 | Induction of PG G/ H synthase-2 in bovine myometrial cells by interferon-r requires the activation of the p38 MAPK pathway 显示文摘 | FLORENCE D B ANTONIS E K | 2001 | Endocrinology2001，142，12： | 1 |
| 14 | Computer-assisted navigation system in pediatric intranasal surgert显示文摘 | Florence P Denis B Francois D | 2002 | Arch Otolaryngol Head Neck Surg2002，128，： | 1 |
| 15 | Immunopotenti · ation of Staphylococcus aureus type 5 capsular polysaecharide CO -entrapped in liposomes with a-toxin 显示文摘 | BURGEOT C FLORENCE B G POUTREL B etal | 2001 | Vaccine2001，19，： | 1 |
| 16 | Determination of Arsenic Species in Marine Organisms by HPLC-ICP-OES and HPLC-HG-QFAAS显示文摘 | Mohammed B Amran Florence Lagarde | 1997 | Mikrochim Acta1997，127，： | 1 |
| 17 | Quantitatian of HCV RNA using real-time PCR and fluorimetry 显示文摘 | Florence K P Glaucia P B Mireille S | 2001 | J Virol Methods2001，95，： | 1 |
| 18 | Factors Influencing Pain Management by Nurses in Emer- gency Departments in Central Africa显示文摘 | Rampanjato R M Florence M Patrick N C Finucane B T | 2007 | Emerg Med J2007，24，7： | 1 |
| 19 | Quantitation of HCV RNA using real-time PCR and fluorimetry显示文摘 | Florence K P Glaucia P B Mireille S | 2001 | J Virol Methods2001，95，： | 1 |
| 20 | Does zinc produce reactive oxygen species in Ruditapes decussatus 显示文摘 | Florence G Maria J B | 2004 | Ecotori Envi Safe2004，57，： | 1 |
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