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| 1 | PCR-ELISA法检测烟曲霉和黄曲霉有助于提高IA的早期诊断率显示文摘背景:现在实验室和放射学中缺乏用于诊断侵袭性曲霉感染(IA)的敏感性和特异性较高的方法。我们预期评价用PCR—ELISA方法对血液中的烟曲霉和黄曲霉DNA进行每两周的测定,以评价它的诊断价值。 | Florent M Katsahian S Vekhoff A 邓妍(编译) | 2006 | 中国处方药2006，，3： | 17 |
| 2 | Fulminant myocarditis in adults: a narrative review显示文摘Fulminant myocarditis(FM)is an uncommon syndrome characterized by sudden and severe hemodynamic compromise secondary to acute myocardial inflammation,often presenting as profound cardiogenic shock,life-threatening ventricular arrhythmias and/or electrical storm.FM may be refractory to conventional therapies and require mechanical circulatory support(MCS).The immune system has been recognized as playing a pivotal role in the pathophysiology of myocarditis,leading to an increased focus on immunosuppressive treatment strategies.Recent data have highlighted not only the fact that FM has significantly worse outcomes than non-FM,but that prognosis and management strategies of FM are heavily dependent on histological subtype,placing greater emphasis on the role of endomyocardial biopsy in diagnosis.The impact of subtype on severity and prognosis will likewise influence how aggressively the myocarditis is managed,including whether MCS is warranted.Many patients with refractory cardiogenic shock secondary to FM end up requiring MCS,with venoarterial extracorporeal membrane oxygenation demonstrating favorable survival rates,particularly when initiated prior to the development of multiorgan failure.Among the challenges facing the field are the need to more precisely identify immunopathophysiological pathways in order to develop targeted therapies,and the need to better optimize the timing and management of MCS to minimize complications and maximize outcomes. | Santiago Montero Darryl Abrams Enrico Ammirati Florent Huang Dirk WDonker Guillaume Hekimian Cosme García-García Antoni Bayes-Genis Alain Combes Matthieu Schmidt | 2022 | Journal of Geriatric Cardiology2022，19，2： | 3 |
| 3 | Use of an Isokinetic Sampling Probe:Results in a Cyclone显示文摘 | Reinhardt B Cordonnier A Florent P | 1999 | Powder Technology1999，101，1： | 1 |
| 4 | Novel two-step SnOJSnO water-splitting cycle for solar ther- mochemical production of hydrogen 显示文摘 | STEPHANE A PATRICE C FLORENT L | 2008 | International Journal of Hydrogen Energy2008，33，： | 1 |
| 5 | An online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information显示文摘 | Florent A Beltran R B | 2005 | BMC Bioinformatics2005，41，6： | 1 |
| 6 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 7 | PHACCS, an onlinetool for estimating the structure and diversity of uncultured viral communities using metagenomic information 显示文摘 | Florent A Beltran R B David B | 2005 | BMC Bioinformaties2005，41，6： | 1 |
| 8 | Influence of chronic lactulose ingestion on the colonic metabolism of lactulose in man (an in vivo study) 显示文摘 | Florent C Flourie B Leblond A | 1985 | J Clin Invest1985，75，2： | 1 |
| 9 | hnpact of body condition score on reproductive performance in large cmmnercial dairy herds显示文摘 | Calraviello D Z Weigel K A Florent M | 2006 | Journal of Dairy Science (submitted)2006，，： | 1 |
| 10 | Emergency liver transplantation for acute liver failure 显示文摘 | PAUWELS A MOSTEFA-KARA N FLORENT C | 1993 | J Hepatol1993，17，： | 1 |
| 11 | Analysis of solar chemical processes for hydrogen production from water splitting thermochemical cycles 显示文摘 | Charvin P Stephane A Florent L | 2008 | Energy Conversion and Management2008，49，6： | 1 |
| 12 | DNA sequencing by hybridization with uligonucleotides 显示文摘 | Lysov Y Florent'ev V Khorlin A | 1998 | Doklady Academy Nauk USSR1998，303，8： | 1 |
| 13 | Flow maldistribution in heat exchangers显示文摘 | LALOT S FLORENT P LANG S K BERGLES A E | 1999 | Applied Thermal Engineering1999，19，8： | 1 |
| 14 | PHACCS,an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information显示文摘 | FLORENT A BELTRAN R B DAVID B | 2005 | BMC Bioinformatics2005，41，6： | 1 |
| 15 | A robust image watermarking chnique based on quantization noise visibility thresholds显示文摘 | FLORENT A V PATRICK L C | 2007 | Signal Processing2007，87，6： | 1 |
| 16 | BDNF parabraehio-a- mygdaloid pathway in morphine-induced analgesia显示文摘 | Maysa S Sophie A P Florent B | 2013 | Int J Neuropsychopharmacol2013，16，7： | 1 |
| 17 | Accidents vasculaires cerebraux apres obturation endoscopique des varices oesophagiennes parlisobtyl-2-cyanoacrylate chez deux malaeds 显示文摘 | See A Florent C Lamy P | 1986 | Gastroenterol Clin Biol1986，10，89： | 1 |
| 18 | Influence of chro- nic lactulose ingestion on the colonic metabolism of lactu- lose in man (an in vivo study) 显示文摘 | Florent C Flourie B Leblond A | 1985 | J Clin Invest1985，75，2： | 1 |
| 19 | Tailofing the anionic function and the side chains of comb-like superplasticizers to improve their adsorp- tian显示文摘 | A Florent Dalas | 2015 | Cement and Concrete Research2015，67，： | 1 |
| 20 | Automatic building extraction from DEMs using an object approach and application to the 3D-city modeling显示文摘 | Florent L A Marc P B | 2008 | Isprs Jour- nal of Photogrammetry and Remote Sensing2008，63，3： | 1 |
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