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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Short-term TPN containing n-3 fatty acids ameliorate lactic induced by endotoxin in guindea pigs显示文摘 | Flores F Hirschberg Y | 1990 | Arm J Clin Nutr1990，52，： | 1 |
| 3 | Digestion of biological materials using the microwave-assisted sample combustion technique 显示文摘 | Mesko M F Moraes D P Barin J S Dressler V L Knapp G Flores E M M | 2006 | Microchem Journal2006，82，： | 1 |
| 4 | Serolog- ic marker candidates among B-cell linear epitopes of Nsp2 and structural proteins of a North American strain of porcine re- productive and respiratory syndrome virus 显示文摘 | DE LIMA M PATTNAIK A K FLORES E F | 2006 | Virology2006，353，2： | 1 |
| 5 | The treatment of hypertrophic scars and keloids显示文摘 | Berman B and F Flores | 1998 | Eur J Dermatol1998，8，8： | 1 |
| 6 | Application of microwave induced combustion in closed vessels for carbon black-containing elastomers decomposition 显示文摘 | Moraes D P Mesko M F Mello P A Paniz J N G Dressler V L Knapp G Flores E M M | 2007 | Spectrochim Acta : Part B2007，62，： | 1 |
| 7 | Genetic variation in the interleukin-8 gene promoter and vaginal concentrations of interleukin--8 are not associated with bacterial vaginosis during pregnancy显示文摘 | Diaz-Cueto L Cuiea Flores A Ziga Cordero F | 2005 | J Reprod Immuno12005，66，2： | 1 |
| 8 | Phytoplankton dynamics in a shallow, hy- pertrophic reservoir ( Lake Arancio, Sicily ) 显示文摘 | Barone R Flores N F | 1994 | Hydrobiol1994，289，： | 1 |
| 9 | Application of neodymium-iron-boron permanent magnets on the assembling of a novel planar actuator显示文摘 | FLORES F A F SUSIN A A SILVEIRA D M A | 1999 | IEEE Transaction on Magnetics1999，35，5： | 1 |
| 10 | Cathepsin B, D, H and L activities in the processing of dry-cured ham 显示文摘 | Toldra F Rico E Flores J | 1993 | J Sci Food Agr1993，62，2： | 1 |
| 11 | Small-strain shear modulus and strength of cement-treated clay显示文摘 | FLORES RD V EMIDIO G D IMPE W F V | 2010 | Geotechnical Testing Journal2010，33，1： | 1 |
| 12 | The effectiveness of grafting to improve salt tolerance in tomato when an 'excluder' genotype is used as scion显示文摘 | Martinez-Rodriguez M M Estan M T Moyano E Garcia- Abellan J O Flores F B Campos J F A1-Azzawi M J Flowers T J Bolarin M C | 2008 | Environmental & Experimental Botany2008，63，1： | 1 |
| 13 | Nitrogen compounds as potential biochemical markers of pork meat quality 显示文摘 | Flores M Moya V Aristoy M Toldr6 F | 2000 | Food Chemistry2000，69，4： | 1 |
| 14 | Acrylic Bone Ce-ments Modified With Bioactive Filler显示文摘 | C F Jasso-Gastinel S G Enriquez J Flores | 2009 | Macromolecular Sym-posia2009，，： | 1 |
| 15 | Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics显示文摘 | MANRIQUEZ D EL-SHARKAWY I FLORES F B | 2006 | Plant Mol Biol2006，61，45： | 1 |
| 16 | A tensorial framework forcolor images 显示文摘 | Rittner L Flores F C Lotufo R A | 2010 | Pattern Recognition Letters2010，31，： | 1 |
| 17 | Developing Productive Customers in Emerging Markets显示文摘 | Letelier MF Flores F Spinosa C | 2003 | California Management Review2003，45，4： | 1 |
| 18 | Binding of aroma compounds by isolated myofibrillar proteins: Effect of protein concentration and conformation 显示文摘 | Pérez-Juan M Flores M Toldrá F | 2007 | Food Chemistry2007，105，3： | 1 |
| 19 | Low-dose amphotericin B and murine dialyzable spleen extracts protect against systemic candida infection in mice显示文摘 | Robledo vila F P6rez Tapia M Lim6n Flores A | 2013 | Clin Dev Immunol2013，2013，19： | 1 |
| 20 | Heat shock proteinsas biochemical markers for postharvest chilling stress in fruits and vegetables显示文摘 | Aghdam M S Sevillano L Flores F B | 2013 | Scientia Horticulturae2013，160，： | 1 |
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