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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Effects of telomerase and telomere length on epidermal stem cell behavior 显示文摘 | Flores I Cayuela ML Blasco MA | 2005 | Science2005，309，5738： | 1 |
| 3 | Limitations in improving detection of pancreatic adenocarcinoma显示文摘 | Mendieta Zerón H García Flores JR Romero Prieto ML | | 0，，05： | 1 |
| 4 | The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression 显示文摘 | Cayuela ML Flores JM Blasco MA | 2005 | EMBO Rep2005，6，3： | 1 |
| 5 | Effects of telomerase and telomere length on epidermal stem cell behavior 显示文摘 | Flores I Cayuela ML Blasco MA | 2005 | Science2005，309，5738： | 1 |
| 6 | Voluntary running prevents progressive memory decline and increases adult hippoeampal neurogenesis and growth factor expression after whole-brain irradiation 显示文摘 | Wong-Goodrich SJ Pfau ML Flores CT | 2010 | Cancer Res2010，70，22： | 1 |
| 7 | Voluntary running prevents progressive memory decline and increases adult hippocampal neurogenesis and growth factor expression after whole-brain irradiation显示文摘 | Wong-Goodrich SJ Pfau ML Flores CT | 2010 | Cancer Res2010，70，22： | 1 |
| 8 | Dental trauma in children and addescents in Valparaiso, Chile显示文摘 | Onetto JE Flores MT Carbarino ML | 1994 | Endod Dent Traumatol1994，10，5： | 1 |
| 9 | Dental trauma in Valparaiso child显示文摘 | Onetto JE Flores ML Garbarino ML | 1994 | Endod Dent Traumatol1994，10，5： | 1 |
| 10 | Evaluaci6n clinica diagn6stica en pacientes con cistitis intersticial显示文摘 | Flores C Gonzdlez-Ruiz Ml Martinez-Espinoza CJ | 2010 | Ginecol Obstet Mex2010，78，5： | 1 |
| 11 | Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis显示文摘 | Kalev-Zylinska ML Horsfield JA Flores MV | 2002 | Development2002，129，8： | 1 |
| 12 | Paclitaxel sensitivity of breast cancer cells requires efficient mitotic arrest and disruption of Bcl- xL/Bak interaction 显示文摘 | Flores ML Castilla C Javila R | 2012 | Breast Cancer Res Treat2012，133，3： | 1 |
| 13 | Dental trauma in children and adolescents in Valparaiso, Chile显示文摘 | Onetto JE Flores MT Garbarino ML | 1994 | Endod Dent Traumatol1994，10，5： | 1 |
| 14 | The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression显示文摘 | Cayuela ML Flores JM Blascola MA | 2005 | EMBO Rep2005，6，3： | 1 |
| 15 | Effects oftelomerase and telomere length on epidermal stem cell behavior显示文摘 | Flores I Cayuela ML Blasco MA | 2005 | Science2005，309，5738： | 1 |
| 16 | Effects of telomerase and telomere length on epidermal stem cell behavior显示文摘 | Flores I Cayuela ML Blasco MA | 2005 | Science2005，309，5738： | 1 |
| 17 | Influence of cone-beam computed tomograph), image artifacts on the determination of dental arch measurements显示文摘 | Gamba TO Oliveira ML Flores IL | 2014 | Angle Orthod2014，84，2： | 1 |
| 18 | Effects of telomerase and telomere length on epidermal stem cell behavior显示文摘 | Flores I Cayuela ML Blasco MA | 2005 | Science2005，309，5738： | 1 |
| 19 | Dental trauma in valparaiso child显示文摘 | ONETTO JE FLORES MT GARBARINO ML | 1994 | Endod Dent Traumatol1994，68，： | 1 |
| 20 | Simultaneous isolation of platelet factor 4 and glycoprotein IIb-IIIa complex from rabbit platelets, and characterization of specific chicken antibodies to assay them 显示文摘 | Santoro ML Barbaro KC Flores da Rocha TR | 2004 | J Immunol Methods2004，284，12： | 1 |
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