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| 1 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 2 | Modifying the Autism Spectrum Rating Scale(6–18 years)to a Chinese Context:An Exploratory Factor Analysis显示文摘The purpose of this study was to explore the psychometric properties of the Chinese version of the autism spectrum rating scale(ASRS). We recruited 1,625community-based children and 211 autism spectrum disorder(ASD) cases from 4 sites, and the parents of all participants completed the Chinese version of the ASRS. A robust weighted least squares means and variance adjusted estimator was used for exploratory factor analysis. The3-factor structure included 59 items suitable for the current sample. The item reliability for the modi?ed Chinese version of the ASRS(MC-ASRS) was excellent. Moreover,with 60 as the cut-off point, receiver operating characteristic analysis showed that the MC-ASRS had excellent discriminate validity, comparable to that of the unmodi?ed Chinese version(UC-ASRS), with area under the curve values of 0.952(95% CI: 0.936–0.967) and 0.948(95% CI:0.930–0.965), respectively. Meanwhile, the con?rm factor analysis revealed that MC-ASRS had a better construct validity than UC-ASRS based on the above factor solution in another children sample. In conclusion, the MC-ASRS shows better ef?cacy in epidemiological screening for ASD in Chinese children. | Hao Zhou Lili Zhang Xuerong Luo Lijie Wu Xiaobing Zou Kun Xia Yimin Wang Xiu Xu Xiaoling Ge Yong-Hui Jiang Eric Fombonne Weili Yan Yi Wang | 2017 | Neuroscience Bulletin2017，33，2： | 8 |
| 3 | Chinese Norms for the Autism Spectrum Rating Scale显示文摘This study aimed to establish norms for the modi?ed Chinese version of the Autism Spectrum Rating Scale(ASRS). Participants were recruited from Shanghai,Harbin, Guangzhou, and Changsha, China, and their parents and teachers were invited to complete the Chinese Parent version and the Teacher version of the ASRS. In both versions, boys had signi?cantly higher sub-scale scores and total score(T-score) by 1–3 and 4–5 points respectively, than girls(both P \ 0.001). Age had weak correlations with some sub-scores and the T-score(r ranged from-0.1859 to 0.0738), and some reached signi?cance(P \ 0.03). The correlations appeared stronger and were more common in females. The T-score based on Chinese norms ideally correlated with the score based on the United States norms in boys and girls for both versions.Norms for the Chinese version of the ASRS for children aged 6–12 years are proposed and may be helpful for screening individuals with autism spectrum disorders from the general population of children. | Hao Zhou Lili Zhang Xiaobing Zou Xuerong Luo Kun Xia Lijie Wu Yimin Wang Xiu Xu Xiaoling Ge Yong-Hui Jiang Eric Fombonne Weili Yan Yi Wang | 2017 | Neuroscience Bulletin2017，33，2： | 5 |
| 4 | Assessing the Accuracy of the Modified Chinese Autism Spectrum Rating Scale and Social Responsiveness Scale for Screening Autism Spectrum Disorder in Chinese Children显示文摘The reported prevalence of autism spectrum disorder(ASD) has been increasing rapidly in many parts of the world. However, data on its prevalence in China are largely missing. Here, we assessed the suitability of the modi?ed Chinese version of a newly-developed ASD screening tool, the Modi?ed Chinese Autism Spectrum Rating Scales(MC-ASRS) in screening for ASD in Chi nese children aged 6–12 years, through comparison with the Social Responsiveness Scale(SRS) that has been widely used for ASD screening. We recruited the par ents/caregivers of 1588 typically-developing children and190 children with ASD aged 6–12 years to complete the MC-ASRS and SRS, and evaluated the validity of both scales in discriminating children with ASD from those developing typically. The results showed that MC-ASRSperformed as well as SRS in sensitivity, speci?city, and area-under-the-curve(both [0.95) in receiver operating characteristic analysis, with a fair false-negative rate.These results suggest that MC-ASRS is a promising tool for screening for children with ASD in the general Chinese population. | Bingrui Zhou Hao Zhou Lijie Wu Xiaobing Zou Xuerong Luo Eric Fombonne Yi Wang Weili Yan Xiu Xu | 2017 | Neuroscience Bulletin2017，33，2： | 5 |
| 5 | Leptinmediated decrease of cyclin A2 and increase of cyclin D1 expression:Relevance for the control of prepubertal rat leydig cell division and differentiation显示文摘 | FOMBONNE J CHARRIER C GODDARD I | 2007 | Endocrinology2007，148，5： | 1 |
| 6 | The Patched dependencereceptor triggers apoptosis through a DRAL-caspase-9 complex显示文摘 | Mille F Thibert C Fombonne J | 2009 | Nat Cell Biol2009，11，6： | 1 |
| 7 | Parental recognition of developmental abnormalities in autism显示文摘 | De Giacomo A Fombonne E | | 0，，07： | 1 |
| 8 | MMR vaccination and pervasive developmental disorders: a case-control study显示文摘 | Smeeth L Cook C Fombonne E | 2004 | Lancet2004，364，： | 1 |
| 9 | A Comparison of DSM-IV Pervasive Developmental Disorder and DSM-5 Autism Spectrum Disorder Prevalence in an Epidemiologic Sample显示文摘 | Young Shin Kim Eric Fombonne Yun-Joo Koh Soo-Jeong Kim Keun-Ah Cheon Bennett L. Leventhal | 2014 | Journal of the American Academy of Child & Adolescent Psychiatry2014，，： | 1 |
| 10 | Twenty-year outcome for individuals with autism and average or near average cognitive abilities显示文摘 | Farley MA McMahon WM Fombonne E | 2009 | Autism Res2009，2，2： | 1 |
| 11 | Regression of language and non-language skill in Pervasive developmental disorders 显示文摘 | Meilleur AA Fombonne E | 2009 | J Intellect Disabil Res2009，53，2： | 1 |
| 12 | Epidemiological surveys of autism and other pervasive developmental disorders: an update显示文摘 | Fombonne E | 2003 | J Autism Der Disorder2003，33，4： | 1 |
| 13 | The epidemiology of autism : A review 显示文摘 | Fombonne E | 1999 | Psychol Med1999，29，6： | 1 |
| 14 | Prevalence and Interpretation of Recent Trends in Rates of Pervasive Developmental Disorders显示文摘 | Fombonne E Quirke S Hagen A | 2009 | McGill J Med2009，12，2： | 1 |
| 15 | Epidemiology of autistic disorder and other pervasive developmental disorders 显示文摘 | Fombonne E | 2005 | J Clin Psychiatry2005，66，10： | 1 |
| 16 | A novel paraptosis pathway involving LEI/L-DNaseII for EGF-induced cell death in somato8lactotrope pituitary cells显示文摘 | Fombonne J Padron L Enjalbert A | 2006 | Apoptosis2006，11，3： | 1 |
| 17 | The prevalence of autism 显示文摘 | FOMBONNE E | 2003 | JAMA2003，289，1： | 1 |
| 18 | Parental recognition of developmental abnormalities in autism显示文摘 | De Giacomo A Fombonne E | 1998 | Eur Child Adolesc Psychiatry1998，7，3： | 1 |
| 19 | p53 alterations in human leukemia-lymphoma cell lines:in vitroartifaet or prerequisite for cell immortalization显示文摘 | Drexler HG Fombonne S Matsuo Y | 2000 | Leukemia2000，14，1： | 1 |
| 20 | Epidemiology of autistic disorder and other pervasive developmental disorders 显示文摘 | Fombonne E | 2005 | J Clin Psychiatry2005，66，10： | 1 |
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