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| 1 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 2 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 3 | Perioperative outcomes of major hepatic resections under low central venous pressure anesthesia: blood loss, blood transfusion, and the risk of postoperative renal dysfunction显示文摘 | Jose A Melendez Vittoria Arslan Mary E Fischer David Wuest William R Jarnagin Yuman Fong Leslie H Blumgart | 1998 | Journal of the American College of Surgeons1998，，6： | 2 |
| 4 | Regional brain asymmetries in major depression with or without an anxiety disorder:A quantitative eleetroencephalographie study显示文摘 | BRUDER G E FONG R TENKE C E | 1997 | Biol Psychiatry1997，41，： | 1 |
| 5 | Interaction of lithotripter shockwaves with single inertial cavitation bubbles显示文摘 | KLASEBOER E FONG S W TURANGAN C | 2007 | Journal of Fluid Mechanics2007，593，： | 1 |
| 6 | Lysyl oxidase-like 2 expres sion is increased in colon and esophageal tumors and associated with less differentiated colon tumors 显示文摘 | Fong SF Dietzsch E Fong KS | 2007 | Genes Chromosomes Cancer2007，46，7： | 1 |
| 7 | Relative CEO underpayment and CEO behav- ior towards R&D spending 显示文摘 | Fong E A | 2010 | Journal of Management Studies2010，47，6： | 1 |
| 8 | Outcome of treatment for extrahepatic bile duct cancer显示文摘 | Fong Y Blumgart LM Lin E | 1996 | Br J Surg1996，83，12： | 1 |
| 9 | Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines显示文摘 | Fong WG Liston P Raican-Separovic E | 2000 | Genomics2000，70，1： | 1 |
| 10 | Prevalence of colorectal polyps in pediatric colonoscopy显示文摘 | Thakkar K Alsarraj A Fong E et al | 2012 | Dig Dis Sci2012，57，4： | 1 |
| 11 | Incidence and progression of epiretinal membranes in eyes after cataract surgery显示文摘 | Fong CS MitchetlP Rochtchina E | 2013 | Am J Ophthalmol2013，156，2： | 1 |
| 12 | Embryonic stem cell lines from human blastocysts:somatic differentiation in vitro (vol 18,pg 402,2000)显示文摘 | Reubinoff B E Pera M F Fong C Y | | 0，，05： | 1 |
| 13 | Activation of the grp78 and grp94 promoters by hepatitis c virus E2 evelope protein 显示文摘 | Liberman E Fong YL Selby MJ | 1999 | Virol1999，73，5： | 1 |
| 14 | Expression of Caveolin-1 and Caveolin-2 in urothclial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiatlon显示文摘 | Fong A Garcia E Gwynn L ct al | 2003 | Am J Clin Pathol2003，120，1： | 1 |
| 15 | Stem cell homing in musculoskeletal injury显示文摘 | Fong E L S Chan C K Goodman S B | 2011 | Biomaterials2011，32，2： | 1 |
| 16 | Expression and genetic analysis of XIAP-associated factor1 (XAF1) in cancer cell lines显示文摘 | FONG W G LISTON P RAICAN-SEPAROVIC E | 2000 | Genomics2000，70，1： | 1 |
| 17 | Rabbit model for Chlamydia pneumoniae infection显示文摘 | Fong IW Chiu B Viira E | 1997 | J Clin Microbiol1997，35，： | 1 |
| 18 | Effect of chlortetraeycline of honeybee worker reared in vitro 显示文摘 | Peng CYS Mussen E Fong A | 1992 | Invertebr Pathol1992，60，： | 1 |
| 19 | Diagnostic molecular biomarkers for malignant pleural effusions显示文摘 | Krishna B Sriram Vandana Relan Belinda E Clarke Edwina E Duhig Ian A Yang Rayleen V Bowman YC Gary Lee Kwun M Fong | 2011 | Future Oncol2011，，6： | 1 |
| 20 | Sustainability of visual acui- ty in the first 2 years after cataract surgery 显示文摘 | Fong C S Mitchell P Rochtchina E | 2011 | Br J Ophthalmol2011，95，12： | 1 |
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