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| 1 | 英国排水管网建模技术实例分析显示文摘基于排水管网水力模型软件(InfoWorks CS),介绍了一个英国小城镇排水管网建模过程。在实例中详述了英国管网建模规范、数据管理、模型构建以及模型检验等方面内容,最后针对我国现阶段的排水管网建模提出了值得借鉴的地方。 | 陈圆 张亚雷 Foong Ying-Chyung 周雪飞 张选军 | 2009 | 中国给水排水2009，25，22： | 7 |
| 2 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 3 | 末次冰期时暴露的巽他大陆架可能被热带稀树草原覆盖吗?显示文摘迄今为止,末次冰期低海平面时南海南部暴露的巽他大陆架被稀树草原或是热带雨林覆盖的问题仍然存有争议。来自于东南亚的孢粉证据表明,末次冰期时南海南部没有出现持续而广泛的草本花粉增多现象,主要的孢粉成分仍为低地雨林和山地雨林。草本花粉占主导的证据多出现在澳大利亚北部,这可能指示了草本植物以现代稀树草原分布区为中心进行扩张。据此,可以认为,尽管末次冰期气候有所变干,但南海南部周边陆地以及暴露的巽他大陆架上可能仍然被热带森林所覆盖。这一推断不仅得到了该区域植被—古气候模拟的支持,也与热带南美洲的很多孢粉证据相对应。通过当前孢粉证据的总结,发现东南亚古植被重建工作存有一些不足,例如海洋孢粉记录数量稀少,缺乏对海洋孢粉组合与内陆植被关系的了解。 | 戴璐 Foong Swee Yeok | 2017 | 地球科学进展2017，32，11： | 5 |
| 4 | Osteoblastic glucocorticoid signaling exacerbates high-fat-diet-induced bone loss and obesity显示文摘Chronic high-fat diet(HFD)consumption not only promotes obesity and insulin resistance,but also causes bone loss through mechanisms that are not well understood.Here,we fed wild-type CD-1 mice either chow or a HFD(43%of energy from fat)for 18 weeks;HFD-fed mice exhibited decreased trabecular volume(-28%)and cortical thickness(-14%)compared to chow-fed mice.In HFD-fed mice,bone loss was due to reduced bone formation and mineral apposition,without obvious effects on bone resorption.HFD feeding also increased skeletal expression of sclerostin and caused deterioration of the osteocyte lacunocanalicular network(LCN).In mice fed HFD,skeletal glucocorticoid signaling was activated relative to chow-fed mice,independent of serum corticosterone concentrations.We therefore examined whether skeletal glucocorticoid signaling was necessary for HFD-induced bone loss,using transgenic mice lacking glucocorticoid signaling in osteoblasts and osteocytes(HSD2^(OB/OCY)-tg mice).In HSD2^(OB/OCY)-tg mice,bone formation and mineral apposition rates were not suppressed by HFD,and bone loss was significantly attenuated.Interestingly,in HSD2^(OB/OCY)-tg mice fed HFD,both Wnt signaling(less sclerostin induction,increased P | Sarah Kim Holger Henneicke Lauryn L.Cavanagh Eugenie Macfarlane Lee Joanne Thai Daphne Foong Sylvia J.Gasparini Colette Fong-Yee Michael M.Swarbrick Markus J.Seibel Hong Zhou | 2021 | Bone Research2021，9，4： | 2 |
| 5 | Change in model for end-stage liver disease score at two weeks,as an indicator of mortality or liver transplantation at 60 days in acute-on-chronic liver failure显示文摘Background:Acute-on-chronic liver failure(ACLF)is characterised by a sudden deterioration of underlying chronic liver disease,resulting in increased rates of mortality and liver transplantation.Early prognostication can benefit optimal allocation of resources.Methods:ACLF was defined as per the disease criteria of the Asian Pacific Association for the Study of the Liver.Inpatient discharge summaries from between January 2001 and April 2013 were reviewed.The primary outcome was mortality or liver transplantation within 60 days from onset of ACLF.Absolute‘model for end-stage liver disease’(MELD)score and change in MELD at Weeks 1,2 and 4 were reviewed in order to identify the earliest point for prediction of mortality or liver transplantation.Results:Clinical data were collected on 53 subjects who fulfilled the inclusion and exclusion criteria.At 60 days from presentation,20 patients(37.7%)died and 4(7.5%)underwent liver transplantation.Increased MELD of-2 after 2 weeks was 75.0%sensitive and 75.9%specific for predicting mortality or liver transplantation.If the MELD score did not increase at 2 weeks,predictive chance of survival was 93.8%over the next 60 days.MELD change at 1 week showed poor sensitivity and specificity.Change at 4 weeks was too late for intervention.Conclusion:Change in MELD score at 2 weeks provides an early opportunity for prognostication in ACLF.A MELD score that does not deteriorate by Week 2 would predict 93.8%chance of survival for the next 60 days.This finding warrants further validation in larger cohort studies. | Rajneesh Kumar Thinesh Lee Krishnamoorthy Hiang Keat Tan Hock Foong Lui Wan Cheng Chow | 2015 | Gastroenterology Report2015，3，2： | 2 |
| 6 | 热带山地表土植硅体组合对植被的指示--以马来西亚Jerai山为例显示文摘热带雨林植物花粉较低的表现力阻碍了东南亚地区冰期时古植被的精确重建。本研究分析了热带地区马来西亚Jerai山的14个不同海拔高度的表土植硅体样品,目的是评估植硅体是否可以作为古植被重建的关键指标。我们发现了17个植硅体形态类型,它们包括鞍型、棒型、多裂梯型、木本不规则形态、矩形、板型、维管组织、方型、块状、塔型、双裂片型、十字型、硅化气孔、球型、椭球型、楔型、楔型泡状细胞等。球型占据绝对优势的植硅体组合区别于热带稀树草原和亚热带常绿阔叶林等植被类型的植硅体组合,很好地指示了热带森林植被。禾本科植硅体较为敏感地指示了其母本植物的零星存在。随着海拔的升高,某些类型的百分比发生略微的变化,如低地龙脑香林带为球型-木本不规则形态-块状组合;丘陵龙脑香林带为球型-塔型-木本不规则形态组合;石楠林带和山地林带为球型-块状-木本不规则形态组合。这些结果显示了东南亚热带森林中的表土植硅体组合具有一定的植被指示意义。 | 白玉 戴璐 Foong Swee Yeok | 2020 | 第四纪研究2020，40，5： | 2 |
| 7 | 路面下水平地埋管热响应试验与数值模拟研究显示文摘近年来,水平式地埋管换热器尤其是路面下水平式地埋管换热器逐步受到国内外学者关注。路面下水平式地埋管换热器利用道路路基施工便利进行安装,可有效节约地埋管换热器前期安装中的钻孔或开挖沟槽费用,且公路作为城镇基础设施,仅中国每年新增公路里程就达100 000 km以上,因此该方案应用潜力较大。为了探究路面下水平地埋管换热器的热扩散半径以及气温对其换热能力的影响,本文采用Geo Cube热响应试验测试仪,对路面下埋深0.5 m的水平串联式地埋管换热器进行了两次加热功率分别为4 k W和6 k W的现场常规热响应试验,并基于4 k W热响应试验参数利用COMSOL软件建立了路面下水平串联式地埋管换热器3D数值模型。研究结果表明:气温波动对路面下地埋管换热器换热能力有显著不利影响。在热响应试验中,该影响会随着加热功率的增大而减小。路面下水平串联式地埋管换热器热扩散半径确定为小于0.75 m,建议地埋管安装间距大于1.5 m以防止热干扰。所建数值模型模拟精度良好,可用于路面下水平串联式地埋管换热器换热过程模拟。 | 朱敦铭 Foong Shen Yang 李云安 | 2020 | 工程地质学报2020，28，5： | 2 |
| 8 | Fabrication process of open surfaces by robotic fibre placement显示文摘 | SHIRINZADEH B ALICI G FOONG C W | 2004 | Robotics and Computer-Integrated Manufacturing2004，20，1： | 1 |
| 9 | Effect of superficial air velocity on solid state fermentation of palm kernel cake in a lab scale fermenter using locally isolated fungal strain显示文摘 | Foong C W Janaun J Krishnaiah K | 2009 | Industrial Crops and Products2009，30，： | 1 |
| 10 | Accelerated start-up and enhanced granulation in upflow anaerobic sludge blanket reactors显示文摘 | Show K Y Wang Y Foong S F | 2004 | Water Res2004，38，： | 1 |
| 11 | A level-set based approach for anterior teeth segmentation in cone beam computed tomography images 显示文摘 | JI D X ONGA S H FOONG K W C | 2014 | Computers in Biology and Medicine2014，50，： | 1 |
| 12 | Horizontal skeletal typing in an ethnic Chinese population with true class Ⅲ malocclusions 显示文摘 | Lew KK Foong WC | 1993 | Br J Orthod1993，20，4： | 1 |
| 13 | Efficient partial-surface reg- istration for 3D objects显示文摘 | Xiao G Ong S H Foong K W C | 2005 | Computer Vision and Image Under- standing2005，98，： | 1 |
| 14 | The levels of reserve metabolites and oxidative enzymes in the cuttings of easy-to-root and difficult-to-root rhododendrons显示文摘 | Foong T W Barnes M F | 1981 | Biochem Physiol Pflanzen1981，，： | 1 |
| 15 | From west to east; experience with adapting a curriculum in evidence-based medicine显示文摘 | Indah S. Widyahening Geert J. M. G. Heijden Foong Ming Moy Yolanda Graaf Sudigdo Sastroasmoro Awang Bulgiba | 2012 | Perspectives on Medical Education2012，，5： | 1 |
| 16 | Morphological criteria for the diagnosis of polycystic ovarian syndrome(PCOS)by 3- dimensional(3D)transvaginal ultrasound(TVUS)显示文摘 | ALLEMAND M PHY J FOONG S C | 2004 | Fertil Steril2004，82，1： | 1 |
| 17 | Perianal fistulae in Crohn's Disease: current and future approaches to treatment 显示文摘 | Keshaw H Foong KS Forbes A | 2010 | Inflamm Bowel Dis2010，16，： | 1 |
| 18 | Phytoremediation of heavy metal contaminated soils and water using vetiver grass 显示文摘 | Truong P N V Foong Y K Hung Y T | 2010 | Environmental Bioengineering2010，11，： | 1 |
| 19 | Open-ended problems for higher-order thinking in mathematics 显示文摘 | Foong Pui Yee | 2000 | Teaching and Learning2000，20，2： | 1 |
| 20 | Accelerated start-up and enhanced granulation in upflow anaerobic sludge blanket reactors显示文摘 | Kuan-Yeow Show Ying Wang Shiu-Feng Foong Joo-Hwa Tay | 2004 | Water Research2004，，9： | 1 |
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