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| 1 | Effect of prophylactic clip placement following endoscopic mucosal resection of large colorectal lesions on delayed polypectomy bleeding: A meta-analysis显示文摘BACKGROUND The role of prophylactic clipping for the prevention of delayed polypectomy bleeding(DPB) remains unclear and conclusions from prior meta-analyses are limited due to the inclusion of variety of resection techniques and polyp sizes.AIM To conduct a meta-analysis on the effect of clipping on DPB following endoscopic mucosal resection(EMR) of colorectal lesions ≥ 20 mm.METHODS We performed a search of PubMed and the Cochrane library for studies comparing the effect of clipping vs no clipping on DPB following endoscopic resection. The Cochran Q test and I^2 were used to test for heterogeneity. Pooling was conducted using a random-effects model.RESULTS Thirteen studies with a total of 7794 polyps were identified, of which data was available on 1701 cases of EMR of lesions ≥ 20 mm. Prophylactic clipping was associated with a lower rate of DPB(1.4%) when compared to no clipping(5.2%)(pooled OR: 0.24, 95%CI: 0.12-0.50, P < 0.001) following EMR of lesions ≥ 20 mm.There was no significant heterogeneity among the studies(I^2 = 0%, P = 0.67).CONLUSION Prophylactic clipping may reduce DPB following EMR of large colorectal lesions.Future trials are needed to further identify risk factors and stratify high risk cases in order to implement a cost-effective preventive strategy. | Fares Ayoub Donevan R Westerveld Justin J Forde Christopher E Forsmark Peter V Draganov Dennis Yang | 2019 | World Journal of Gastroenterology2019,25,18: | 9 |
| 2 | Do statins reduce hepatitis C RNA titers during routine clinical use?显示文摘AIM: To compare hepatitis C virus (HCV) titers in patients with chronic hepatitis C with and without exposure to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins).METHODS: Medical records were reviewed for 6463 patients with documented HCV infection at a single center between March 2004 and September 2006. Patients with confi rmed viremia and meeting inclusion criteria were assigned to one of three groups: Group A (n = 50), dyslipidemic patients with statin usage during HCV RNA polymerase chain reaction (PCR) determination; Group B (n = 49), dyslipidemic patients with prior or future statin usage but not at the time of HCV RNA PCR determination; and Group C (n = 102), patients without statin usage during the study period. The primary analysis explored the effect of statin therapy on HCV viremia. Secondary analyses assessed class effect, dose response, and effect of other lipid-lowering therapies on HCV viral titers.RESULTS: Median HCV RNA titers did not signif icantly differ among the three groups (Group A: 4 550 000 IU/mL, Group B: 2 850 000 IU/mL, Group C: 3 055 000 IU/mL).For those subjects with longitudinal assessment of HCV viremia prior to and while on statins, there were no signif icant differences between pre- and post-HCV viral titers. Additionally, no differences in HCV titers were observed at any dose level of the most prescribed statin, simvastatin. However, hypertriglyceridemia independently correlated with HCV titers, and niacin exposure was associated with signif icantly lower viral titers (P < 0.05).CONCLUSION: There was no apparent effect of statins on HCV viral replication in this analysis. Further investigation is warranted to explore the possible antiviral properties of triglyceride-lowering agents and their potential role as adjuncts to standard HCV therapy. | Kimberly A Forde Connie Law Rose O’Flynn David E Kaplan | 2009 | World Journal of Gastroenterology2009,15,40: | 2 |
| 3 | Acute sensorineural hearing loss associated with peginterferon and ribavirin combination therapy during hepatitis C treatment: Outcome after resumption of therapy显示文摘Peginterferon and ribavirin combination therapy for the treatment of hepatitis C virus (HCV) is well known to be associated with significant adverse effects. Sensorineural hearing loss, that in most cases is unilateral, has been reported as a consequence of therapy with both non-pegylated and pegylated interferon (pegIFN) but is not a well-known adverse effect. We report a 45-year-old Caucasian woman who developed acute sensorineural hearing loss 2 mo after starting therapy with pegIFN-α 2b and ribavirin for the treatment of chronic HCV, genotype 1a. She did not report the hearing loss to the hepatitis clinic until L mo,later whereupon therapy was promptly discontinued.Although her serum alanine aminotransferase (ALT)normalized and her HCV-RNA became undetectable after 12 wk of pegIFN and ribavirin therapy, after discontinuation,her HCV-RNA became detectable with significant elevations of serum ALT. Four months after initial discontinuation,the patient re-commenced pegIFN and ribavirin combination therapy. After 44 of 48 wk of therapy, the patient's liver biochemistry has normalized and the HCV-RNA is undetectable. She has not developed worsening of her hearing loss and hearing on the left-side is unaffected.Both patients and physicians should be aware that sensorineural hearing loss may occur with pegIFN therapy.Our experience suggests that re-institution of therapy is not always associated with further hearing impairment. | Victor K Wong Cindy Cheong-Lee Jo-Ann E Ford Eric M Yoshida | 2005 | World Journal of Gastroenterology2005,11,34: | 2 |
| 4 | 基于FANS的温室风机通风性能测试显示文摘试验采用Fansassessmentnumerationsystem(FANs)为现场监测系统,利用位置上下移动持续运行的螺旋桨风速计和静压传感器对风机通风性能进行测试。试验共测定3个玻璃温室内3种类型共9个排风风机在不同工况下静压5.O~61.5Pa范围内的通风量和能源消耗。结果显示,风机防护网的存在及清洁状况对通风量的影响低于5%;塑料百叶窗风机比相同配置的铝制百叶窗风机通风量和能效分别平均高13.1%、15.1%;参数完全相同的风机能效差异最高达12.7%;胶带驱动的风机转速减少16.1%时通风量平均降低38.7%;温室内静压超过30Pa时风机能耗显著增加。 | 张智 Steven E Ford Richard S Gates 邹志荣 | 2014 | 农业机械学报2014,45,11: | 2 |
| 5 | Prevalence of the metabolic syndrome in indi-viduals with hyperuricemia 显示文摘 | Choi H K Ford E S | 2007 | Am J Med2007,120,5: | 1 |
| 6 | The role of the surgeon in the evolution of flexible endoscopy显示文摘 | Morgenthal C B Richards W O Dunkin B J Forde K A Vitale G Lin E | 2007 | Surg Endosc2007,21,6: | 1 |
| 7 | Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans 显示文摘 | Castillo U F Strobel G A Ford E J | 2002 | Microbiology2002,148,9: | 1 |
| 8 | Munumbicins, wide spectrum antibiotics produced by Streptomyces endophytic on Kennedia nigriscans显示文摘 | CASTILLO U F STROBEL G A FORD E J | 2002 | Microbiology2002,148,: | 1 |
| 9 | Neonicotinoid insecticides induce salicylate-associated plant defense responses 显示文摘 | FORD K A CASIDA J E CI-{ANDRAN D | 2010 | PNAS2010,107,17: | 1 |
| 10 | Acin: a 1, 3-di- hydroisobenzofuran from Pestalotiopsis microspora possessing an- tioxidant and antimycotic activities显示文摘 | Harper J K Ford E J Strobe1 G A | 2003 | Tetrahedron2003,59,: | 1 |
| 11 | Cross-reactivity of Gro- EL antibodies with human heat shock protein 60 and quantifica- tion of pathogens in atherosclerosis 显示文摘 | Ford PJ Gemmell E Hamlet SM | 2005 | Oral Microbiol Immu- nol2005,20,5: | 1 |
| 12 | Depression is a risk factor for coronary artery disease in men : the precursors study 显示文摘 | FORD D E MEAD L A CHANG P P | 1998 | Arch Intern Med1998,158,: | 1 |
| 13 | Pestacin:a 1,3-dihydro isobenzofuran from Pestalotiopsis microspora possessing antioxidant and antimycotic activities显示文摘 | HARPER J K ARIF A M FORD E J | 2003 | Tetrahedron2003,59,14: | 1 |
| 14 | Information systems research and Hofstede's culture's consequences:An uneasy and incomplete partnership显示文摘 | Ford D P CoaneUy C E Meister D B | 2003 | IEEE Transactions on Engineering Management2003,50,1: | 1 |
| 15 | Use of regularly scheduled albuteol treatment in asthma:Genotype-strtified,randomized,placebo-controlled cross-over trail显示文摘 | Israel E Chinchilli VM Ford JG | 2004 | Lancet2004,364,9444: | 1 |
| 16 | Promise and problems with supply chain management approaches to health care purchasing显示文摘 | Ford E W Scanlon D P | 2007 | Academy of Management Proceedings2007,32,3: | 1 |
| 17 | National estimates of adverse events during nonpsychiatric hospitalizations for persons with schizophrenia 显示文摘 | Khaykin E Ford DE Pronovost PJ | | General hospital psy- chiatry0,32,4: | 1 |
| 18 | Relationship between placental vascular endothelial growth factor expression and placental/endometrial vascularity in the pig 显示文摘 | Vonnahme K A Wilson M E Ford S P | 2001 | Biol Reprod2001,64,6: | 1 |
| 19 | Defining the metabolic syndrome in children and adolescents: will the real definition please stand up?显示文摘 | Ford E S Li C | 2008 | J Pediatr2008,152,2: | 1 |
| 20 | Correlation of structural class with no-observed-effect levels: a proposal for establishing a threshold of concern 显示文摘 | Munro IC Ford RA Kennepohl E | 1996 | Food Chem Toxicol1996,34,9: | 1 |