|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Helicobacter pylori upregulates prion protein expression in gastric mucosa: A possible link to prion disease显示文摘AIM: Pathological prion protein (PrPSC) is responsible for the development of transmissible spongiform encephalopathies (TSE). While PrPc enters the organism via the oral route, less data is available to know about its uptake and the role of gastrointestinal inflammation on the expression of prion precursor PrPc, which is constitutively expressed in the gastric mucosa.METHODS: We studied PrPc expression in the gastric mucosa of 10 Helicobacter pylori-positive patients before and after successful H pylori eradication compared to non-infected controls using RT-PCR and Western blotting.The effect of central mediators of gastric inflammation,i.e., gastrin, prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) on PrPc expression was analyzed in gastric cell lines.RESULTS: PrPc expression was increased in H pyloriinfection compared with non-infected controls and decreased to normal after successful eradication. Gastrin,PGE2, and IL-1β dose-dependently upregulated PrPc in gastric cells, while TNF-α had no effect.CONCLUSION: H pylori infection leads to the upregulation of gastric PrPc expression. This can be linked to H pylori induced hypergastrinemia and increased mucosal PGE2 and IL-1β synthesis.H pylori creates a milieu for enhanced propagation of prions in the gastrointestinal tract. | Peter C Konturek Karolina Bazela Vitally Kukharskyy Michael Bauer Eckhart G Hahn Detlef Schuppan | 2005 | World Journal of Gastroenterology2005，11，48： | 9 |
| 2 | Antimicrobial activity,cytotoxicity,and phytochemical screening of Voacanga globosa(Blanco) Merr.leaf extract(Apocynaceae)显示文摘Objective:To determine the antibacterial,antifungal,antiprotozoal,cytotoxic,and phytochemical properties of ethanol extracts of leaves of Voacanga globosa(Blanco) Merr.(V.globosa). Methods:The extracts were tested against bacteria and fungus through disc diffusion assay; against protozoa through growth curve determination,antiprotozoal and cytotoxicity assays. Results:The extract revealed antibacterial activities,inhibiting the growth of Staphylococcus aureus,Bacillus cereus,Pseudomonas aeruginosa,Micrococcus luteus,and Salmonella typhimurium.Antifungal assay showed that it inhibited Candida albicans.The antiprotozoal assay against Trichomonas vaginalis and Entamoeba histolytica showed that V.globosa can inhibit the parasites,wherein the action can be comparable to metronidazole.With the in situ cell death detection kit.Trichomonas vaginalis and Entamoeba histolytica exposed to V.globosa leaf extract was observed to fluoresce simultaneously in red and yellow signals signifying apoptotic-like changes.Preliminary phytochemical screening revealed the chemical composition of plant extract containing alkaloids,saponins,2-deoxysugars,and hydrolysabie tannins.Conclusions: Thus,thus study provides scientific evidence on the traditional use of V.globosa leaf extract in treating microbial diseases.Further,the leaf extract can possibly be used to produce alternative forms of antimicrobials. | Pierangeli G Vital Windell L Rivera | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 5 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Detection of Mycobacterium tuberculosis complex in cattle by PCR using milk,lymph node aspirate,and nasal swabs显示文摘 | Vitale F Capra G Maxia L | 1998 | Journal of Clinical Microbiology1998，36，4： | 1 |
| 5 | The role of the surgeon in the evolution of flexible endoscopy显示文摘 | Morgenthal C B Richards W O Dunkin B J Forde K A Vitale G Lin E | 2007 | Surg Endosc2007，21，6： | 1 |
| 6 | Effect of trimetazi- dine on quality of life in elderly patients with ischemic dilat- ed cardiomyopathy显示文摘 | Marazzi G Gebara O Vitale C | 2009 | Adv Ther2009，26，4： | 1 |
| 7 | Treatment of acute respiratory failure secondaryto pulmonary edema with bilevel positive airway pressure by nasal mask 显示文摘 | Lo Coco A Vitale G Marchese S | 2001 | Monaldi Arch Chest Dia2001，63，： | 1 |
| 8 | Effect of trimetazidine on quality of life in elderly patients wih ischemic dilated cardiomyopathy显示文摘 | Marazzi G Gebara O Vitale C | 2009 | Adv Ther2009，26，4： | 1 |
| 9 | Identification of a TGF-beta responsive element in the human elastin promoter显示文摘 | Margio V Volpin D Vitale G | 1994 | Biochem Biophys Res Commun1994，99，2： | 1 |
| 10 | Detection of mycobacterium tuberculosis complex in cattle by PCR using milk, lymph node, aspirates, and nasal swaps 显示文摘 | Vitale F Capra G Maxia L | 1998 | Journal of Clinical Microbiology1998，36，4： | 1 |
| 11 | Cardiovascular health in the menopausal woman:impact of the timing of hor-mone replacement therapy 显示文摘 | Rosano G Vitale C Spoleti'ni I | 2012 | Climacteric2012，15，15： | 1 |
| 12 | Film conden- sation in inclined tubes with noncondensable gases: An experimental study on the local heat transfer coefficient 显示文摘 | Caruso G Vitale Di Maio D Naviglio A | 2013 | International Communications in Heat and Mass Transfer2013，45，： | 1 |
| 13 | Diagnosis and classification of relapsing polychondritis显示文摘 | Cantarini L Vitale A Brizi M G | 2014 | J Autoimmun2014，4849，2： | 1 |
| 14 | Clinico-biological features of 5202 patients with acute lymphoblastic leukemia enrolled in the Italian AIEOP and GIMEMA protocols and stralified in age cohorts显示文摘 | Chiaretti S Vitale A Cazzaniga G | 2013 | Haematologica2013，98，11： | 1 |
| 15 | Metabolic effect of telmisartan and Losartan in hypertensive patients with metabolic syndrome显示文摘 | Vitale C Mercuro G Castiglioni C | 2005 | Cardiovasc Diabetoh2005，4，1： | 1 |
| 16 | Purification and partial character- ization of a peroxidase from plant cell cultures of cassia didymo- botrya and biotransformation studies显示文摘 | Vitall A Botta B Monache G D | 1998 | Biochemical Journal1998，331，2： | 1 |
| 17 | Selective Cyclooxygenase-1 inhibition by P6 and gastrotoxicity: preliminary investigation显示文摘 | Perrone M G Lofrumento D D Vitale P | 2015 | Pharmacology2015，95，12： | 1 |
| 18 | Body position changes redistribute lung computed tomographic density in patients with acute respiratory failure显示文摘 | GATTINONI L PELOSI P VITALE G | 1991 | Anesthesiology1991，74，1： | 1 |
| 19 | Panax notognseng (Burk) effects fibrinogen and lipid plasma lever in rats fed on a high-fat diet 显示文摘 | Cicero A F Vitale G Savion G | 2003 | Phytother Res2003，17，2： | 1 |
| 20 | Preva- lence of malnutrition in general medical patients显示文摘 | BRUCE R S BLACKBURN G L VITALE J | 1976 | JAMA1976，235，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员