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| 1 | MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis b- and c-related-hepatocellularcarcinoma显示文摘Aim of the present review is to summarize the current knowledge about the potential relationship between mi RNAs and hepatitis B virus(HBV)-hepatitis C virus(HCV) related liver diseases. A systematic computerbased search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Statement, was performed to identify relevant studies on usefulness of serum/plasma/urine mi RNAs, as noninvasive biomarkers for early detection of HBV and HCV-induced hepatocellular carcinoma(HCC) development, as well as for its prognostic evaluation. The used Medical Subject Headings terms and keywords were: 'HBV', 'HCV', 'hepatocellular carcinoma', 'micro RNAs', 'mi RNAs', 'diagnosis', 'prognosis', 'therapy', 'treatment'. Some serum/plasma mi RNAs, including mi R-21, mi R-122, mi-125a/b, mi R-199a/b, mi R-221, mi R-222, mi R-223, mi R-224 might serve as biomarkers for early diagnosis/prognosis of HCC, but, to date, not definitive results or well-defined panels of mi RNAs have been obtained. More well-designed studies, focusing on populations of different geographical areas and involving larger series of patients, should be carried out to improve our knowledge on the potential role of mi RNAs for HCC early detection and prognosis. | Sirio Fiorino Maria Letizia Bacchi-Reggiani Michela Visani Giorgia Acquaviva Adele Fornelli Michele Masetti Andrea Tura Fabio Grizzi Matteo Zanello Laura Mastrangelo Raffaele Lombardi Luca Di Tommaso Arrigo Bondi Sergio Sabbatani Andrea Domanico Carlo Fabbri Paolo Leandri Annalisa Pession Elio Jovine Dario de Biase | 2016 | World Journal of Gastroenterology2016，22，15： | 25 |
| 2 | Endoscopic ultrasound-guided fine needle aspiration with 22- and 25-gauge needles in solid pancreatic masses: A prospective comparative study with randomisation of needle sequence显示文摘 | Carlo Fabbri Anna Maria Polifemo Carmelo Luigiano Vincenzo Cennamo Paola Baccarini Guido Collina Adele Fornelli Sandro Macchia Nicola Zanini Elio Jovine Marta Fiscaletti Angela Alibrandi Nicola D’Imperio | 2011 | Digestive and Liver Disease2011，，8： | 1 |
| 3 | Microcalcifications in ductal carcinoma in situ of the breast:histochemical and immunohistochemical study显示文摘 | Foschini M P Fornelli A Peterse J L | 1996 | Hum Pathol1996，27，2： | 1 |
| 4 | Effects of botanicals and combined hormone therapy on cognition in postmenopausal women显示文摘 | Maki PM Rubin LH Fornelli D | 2009 | Menopause2009，16，6： | 1 |
| 5 | Influence of mycotoxin zearalenone and its derivatives (alpha and beta zearalenol) on apoptosis and proliferation of cul- tured granulosa cells from equine ovaries 显示文摘 | Minervini F Giannoccaro A Fornelli F | 2006 | Reprod Biol Endoerinol2006，30，4： | 1 |
| 6 | Microcalci-fications in ductal carcinoma in situ of the breast:histochemicaland immunohistochemical study显示文摘 | FOSCHINI M P FORNELLI A PETERSE J L | 1996 | Hum Pathol1996，27，2： | 1 |
| 7 | Provenace and tectonic implications of heavy minerals in Pliocene-Pleistocene siliciclastic sediments of the southern Apennines,Italy显示文摘 | Acquafredda P Fornelli A Piccarreta G | 1997 | Sedimentary Geology1997，113，： | 1 |
| 8 | Provenance and tectonic implications of heavy minerals in Pliocene-Pleistocene siliclastic sediments of southern Apennines显示文摘 | Acquafredda P Fornelli A Piccarrcta G | 1997 | Sedimen tary Geology1997，，113： | 1 |
| 9 | Effects of botanicals and combined hormone therapy on cognition in postmenopausal women 显示文摘 | Maki PM Rubin LH Fornelli D | 2009 | Menopause2009，16，6： | 1 |
| 10 | Cytotoxic effects of the mycotoxin beauvericin to human cell lines of myeloid origin 显示文摘 | Calo L Fornelli F Ramires R | 2004 | Pharmaeol Res2004，49，1： | 1 |
| 11 | Influence of mycotoxin zearalenone and its deriv-atives (alpha and beta zearalenol) on apoptosis andproliferation of cultured granulosa cells from equine o-varies 显示文摘 | MINERVINI F GIANNOCCARO A FORNELLI F | 2006 | Reproductive Biology and Endocrinology2006，4，1： | 1 |
| 12 | Merkel cell carcinoma of the parotid gland associated with Warthin tumour: report of two cases显示文摘 | Eusebi V Pasquinelli G | 2001 | Histopathology2001，39，： | 1 |
| 13 | Bioavailability and Toxicity of Pentachlorophenol in Contaminated Soil Evaluated on Coelomocytes of Eisenia Andrei ( Annelida: Lumbricidae) 显示文摘 | Vernile P Fornelli F Bari G | 2007 | Toxicol In Vitro2007，21，： | 1 |
| 14 | T-2 toxin immunotoxicity on human B and T lymphoid cell lines显示文摘 | Minervini F Fornelli F Lucivero G | 2005 | Toxicology2005，210，1： | 1 |
| 15 | Possible association between hepatitis C virus and malignancies different from hepatocellular carcinoma:A systematic review显示文摘AIM: To summarize the current knowledge about the potential relationship between hepatitis C virus(HCV) infection and the risk of several extra-liver cancers. METHODS: We performed a systematic review of the literature, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis(PRISMA) Statement. We extracted the pertinent articles, published in MEDLINE and the Cochrane Library, using the following search terms: neoplasm/cancer/malignancy/tumor/carcinoma/adeno-carcinoma and non-Hodgkin lymphomas, kidney/renal-, cholangio-, pancreatic-, thyroid-, breast-,oral-, skin-, prostate-, lung-, colon-, stomach-, haematologic. Case series, case-series with control-group, case-control, cohort-studies as well as meta-analyses, written in English were collected. Some of the main characteristics of retrieved trials, which were designed to investigate the prevalence of HCV infection in each type of the above-mentioned human malignancies were summarised. A main table was defined and included a short description in the text for each of these tumours, whether at least five studies about a specific neoplasm, meeting inclusion criteria, were available in literature. According to these criteria, we created the following sections and the corresponding tables and we indicated the number of included or excluded articles, as well as of meta-analyses and reviews:(1) HCV and haematopoietic malignancies;(2) HCV and cholangiocarcinoma;(3) HCV and pancreatic cancer;(4) HCV and breast cancer;(5) HCV and kidney cancer;(6) HCV and skin or oral cancer; and(7) HCV and thyroid cancer. RESULTS: According to available data, a clear correlation between regions of HCV prevalence and risk of extra-liver cancers has emerged only for a very small group of types and histological subtypes of malignancies. In particular, HCV infection has been associated with:(1) a higher incidence of some B-cell Non-HodgkinLymphoma types, in countries, where an elevated prevalence of this pathogen is detectable, accounting to a percentage of about 10%;(2) an increased risk of intra-hepatic cholangiocarcinoma; and(3) a correlation between HCV prevalence and pancreatic cancer(PAC) incidence. CONCLUSION: To date no definitive conclusions may be obtained from the analysis of relationship between HCV and extra-hepatic cancers. Further studies, recruiting an adequate number of patients are requiredto confirm or deny this association. | Sirio Fiorino Letizia Bacchi-Reggiani Dario de Biase Adele Fornelli Michele Masetti Andrea Tura Fabio Grizzi Matteo Zanello Laura Mastrangelo Raffaele Lombardi Giorgia Acquaviva Luca di Tommaso Arrigo Bondi Michela Visani Sergio Sabbatani Laura Pontoriero Carlo Fabbri Andrea Cuppini Annalisa Pession Elio Jovine | 2015 | World Journal of Gastroenterology2015，21，45： | 1 |
| 16 | Microcalcificatcations in ductal carcinoma in situ of the breast:histochemical and immunohistochemical stud显示文摘 | Foschini M P Fornelli A Peterse J L | 1996 | Radiology1996，27，2： | 1 |
| 17 | T-2 toxinimmuno toxicity on human B and tlymphoid cell lines 显示文摘 | Minervini F Fornelli F Lucivero G | 2005 | Toxicol2005，210，： | 1 |
| 18 | Provenance and tectonic implications of heavy minerals in Pliocene--Pleistocene silicielastic sediments of the southern Apennines, Italy 显示文摘 | Acquafredda P Fornelli A Piecarreta G | 1997 | Sedimentary Geology1997，113，： | 1 |
| 19 | T-2 Toxin immunotoxicity on human B and T lymphoid cell lines 显示文摘 | Minervini F Fornelli F Lucivero G | 2005 | Toxicology2005，210，8： | 1 |
| 20 | Atmospheric pressure plasma deposition of thin films by Townsend dielectric barrier discharge显示文摘 | Massines F Gherardi N Fornelli A | | 0，，05： | 1 |
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