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您的检索式：作者名="Forough Iranpak"
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| 1 | Syringic acid induces cancer cell death in the presence of Cu(Ⅱ)ions via pro-oxidant activity显示文摘Objective:To investigate the effects of syringic acid on HEK 293 and HepG2 cells in the absence and presence of exogenous Cu(Ⅱ)and Fe(Ⅱ)ions.Methods:The antiproliferative effects of syringic acid on HEK 293 and HepG2 cells in the absence and presence of exogenous Cu(Ⅱ)and Fe(Ⅱ)ions were examined by MTT assay.Additionally,colony-forming,reactive oxidative species(ROS)generation,apoptosis induction,autophagy,mitochondrial membrane potential,and mitochondrial mass were investigated.Results:At 24 and 72 h,no significant differences were observed in the viability of HepG2 cells between the control and syringic acid+Fe(Ⅱ)groups.However,exposure of HepG2 cells to syringic acid+Cu(Ⅱ)for 72 h reduced the cell viability significantly.Furthermore,ROS formation,induction of apoptosis,and autophagic vacuoles were significantly increased in HepG2 cells without marked changes in mitochondrial membrane potential and mitochondrial mass.Moreover,syringic acid+Cu(Ⅱ)reduced the plating efficiency and surviving fraction significantly.Conclusions:The combination of syringic acid with Cu(Ⅱ)was toxic to cancer cells and showed pro-oxidant activity.In addition,this combination induced autophagy in cancer cells with less cytotoxic effects on normal cells,which is a potential candidate for the development of novel therapeutics towards cancer. | Marzieh Rashedinia Azita Nasrollahi Marzieh Shafaghat Shahrzad Momeni Forough Iranpak Jamileh Saberzadeh Rita Arabsolghar Zahra Sabahi | 2022 | Asian Pacific Journal of Tropical Biomedicine2022，12，6： | 0 |
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