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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 3 | Proton exchange membrane(PEM)electrolyzer operation under anode liquid and cathode vapor feed configurations显示文摘 | GREENWAY S D FOX E B EKECHUKWU A A | 2009 | International Journal of Hydrogen Energy2009，34，16： | 1 |
| 4 | Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events(TRA 2°P)-TIMI 50 trial 显示文摘 | MORROW D A SCIRICA B M FOX K A | 2009 | Am Heart J2009，158，3： | 1 |
| 5 | Developments in clinical cell therapy显示文摘 | Stroncek D Berlyne D Fox B | 2010 | Cytotherapy2010，12，3： | 1 |
| 6 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 7 | The role of soil surface crusting in desertification and strategies to reduce crusting显示文摘 | Fox D M Bryan R B Price A G | 2004 | Environmental Monitoring and Assessment2004，99，13： | 1 |
| 8 | Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study显示文摘 | D Ross Camidge Yung-Jue Bang Eunice L Kwak A John Iafrate Marileila Varella-Garcia Stephen B Fox Gregory J Riely Benjamin Solomon Sai-Hong I Ou Dong-Wan Kim Ravi Salgia Panagiotis Fidias Jeffrey A Engelman Leena Gandhi Pasi A J?nne Daniel B Costa Geoffrey | 2012 | Lancet Oncology2012，，10： | 1 |
| 9 | Trends in Biotechnology,显示文摘 | Fox D B Moody T S | 2001 | 19:292001，19，： | 1 |
| 10 | Study of fault ride-through for DFIG based wind turbines 显示文摘 | Bing X Fox B Flylnn D | 2004 | IEEE Trans on Electric Utility Deregulation2004，1，5： | 1 |
| 11 | Association of tumour necrosis factor alpha and its receptors with thymidine phospho- rylase expression in invasive breast carcinoma显示文摘 | Leek R D Landers R Fox S B | 1998 | Br J Cancer1998，77，12： | 1 |
| 12 | The relationship of soil loss by interrill erosion to slope gradient显示文摘 | Fox D M Bryan R B | 1999 | Catena1999，38，3： | 1 |
| 13 | Spatial pattern of six sympatric leaf variants and two size classes of Acacia aneura in a semi-arid region of Western Australia显示文摘 | LAMONT B B FOX J E D | 1981 | Oikos1981，37，： | 1 |
| 14 | Predators suppress Aphis glycines Matsumura population growth in soybean 显示文摘 | Fox T B Landis D A Cardoso F F | 2004 | Environ Entomo12004，33，： | 1 |
| 15 | The afterglow of GRB 050709 and the nature of the short-hard γ-ray bursts显示文摘 | FOX D B FRAIL D A PRICE P A | 2005 | Nature2005，437，： | 1 |
| 16 | Cytokine-receptor pai- ring: accelerating discovery of cytokine function 显示文摘 | Foster D Parrish-Novak J Fox B | 2004 | Nat Rev Drug Discov2004，3，2： | 1 |
| 17 | Molecular clones of the mouse complex derived from microdissected metaphase chromosomes显示文摘 | Rohme D Fox H Herrmann B | 1984 | Cell1984，36，3： | 1 |
| 18 | The influence of slope angle on final infiltration rate for interrill conditions显示文摘 | Fox D M Bryan R B Price A G | 1997 | Geoderma1997，80，12： | 1 |
| 19 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 20 | Cloning and sequence analysis of two Pseudomonas flavoprotein xenobiotic reductases 显示文摘 | Blehert D Fox B Chambliss G | 1999 | J Bacteriol1999，181，： | 1 |
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