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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | A small molecule that directs differentiation of human ESCs into the pancreatic lineage 显示文摘 | Chen S Borowiak M Fox JL | 2009 | NatChem Biol2009，5，4： | 1 |
| 3 | The human brain isintrinsically organized into dynamic, anticorrclatcd functionalnetworks显示文摘 | Fox MD Snyder AZ Vinccnt JL ct al | 2005 | Proc Natl Acad Sci USA2005，102，27： | 1 |
| 4 | The human brain is intr- insically organized into dynamic, anticorrelated functional networks显示文摘 | Fox MD Snyder AZ Vincent JL | 2005 | Proe Natl Acad Sci U S A2005，102，27： | 1 |
| 5 | Petrsoal approach for petroclival meningiomas 显示文摘 | AL-Mefty O Fox JL Smith RR | 1988 | Neurosurgery1988，22，3： | 1 |
| 6 | The microsurgical approach to intracranial aneurysms显示文摘 | Yasargil MG Fox JL | 1975 | Surg Neurol1975，3，1： | 1 |
| 7 | The opermive approach to aneurysms of anterior conlmunicating artery 显示文摘 | Yasargil MG Fox JL Ray MW | 1975 | Adv Tech Stand1975，2，： | 1 |
| 8 | The human brain is intrinsically organized into dynamic, anticorrelated functional net- works显示文摘 | Fox MD Snyder AZ Vincent JL | 2005 | Proc Natl Acad Sci USA2005，102，27： | 1 |
| 9 | The myc-miR-17,92axis blunts TGF-βsignaling and production of multiple TGF-β-dependent antiangiogenic factors显示文摘 | Dews M Fox JL Hultine S | 2010 | Cancer Res2010，70，20： | 1 |
| 10 | Gene therapy safety issues come to fore显示文摘 | Fox JL | 1999 | Nat Biotechnol1999，17，9： | 1 |
| 11 | Induction of skin carcino- genieity by alcohol and ultraviolet light 显示文摘 | Saladi RN Nektalova T Fox JL | 2010 | Clin Exp Dermatol2010，35，1： | 1 |
| 12 | Petmsal approach for petroclival meningiomas 显示文摘 | A1-Mefty O Fox JL Smith RR | 1988 | Neurosurgery1988，22，3： | 1 |
| 13 | Stability of ondansetron hydrochloride and dexamethasone sodium phosphate in in- fusion bags and syringes for 32 days显示文摘 | Hagan RL Mallett MS Fox JL | 1996 | Am J Health Syst Pharm1996，53，12： | 1 |
| 14 | The human brain is intrinsically organized into dynamic, anticorrelated functional networks显示文摘 | Fox MD Snyder AZ Vincent JL | 2005 | Proc Natl Acad Sci U S A2005，102，： | 1 |
| 15 | Does registration of PET and planning CT image decrease inteobserver and intaobserver variation in delineating tumor volumes for non-small cell lung cancer? 显示文摘 | Fox JL Rengan R O'Meara W | 2005 | Int J Radiat Oncol Biol Phys2005，62，1： | 1 |
| 16 | The microsurgical approach to acoustic neurinomas显示文摘 | Yasargil MG Fox JL | 1974 | Surg Neurol1974，2，6： | 1 |
| 17 | Ionic mechanism of electrical altemans显示文摘 | Fox JJ McHarg JL Jr Gilmour RF | 2002 | Am J Phys Heart Circ Phys2002，282，： | 1 |
| 18 | A small molecule that directs differentiation of human ESCs into the pancreatic lineage显示文摘 | Chen S Borowiak M Fox JL | | 0，，04： | 1 |
| 19 | Late-stage maturation of the Rieske Fe/S protein:Mzm1 stabilizes Rip1 but does not facilitate its translocation by the AAA ATPase Bcs1显示文摘 | Cui TZ Smith PM Fox JL Khalimonchuk O Winge DR | 2012 | Mol Cell Biol2012，32，： | 1 |
| 20 | Fluorescence in situ hybridization: powerful molecular tool for cancer prognosis显示文摘 | Fox JL Hsu PH Legator MS | 1995 | Clin Chem1995，41，11： | 1 |
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