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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Radiation dose reduction for CT lung cancer screening using ASIR and MBIR: a phantom study显示文摘 | Mathieu K B Ai H Fox P S | 2014 | J Appl Clin Med Phys2014，15，2： | 1 |
| 3 | An apparently new transmissible disease of cattle显示文摘 | OLAFSON P MAC C A FOX F H | 1946 | Cornell Vet1946，36，： | 1 |
| 4 | AMMI adjustment for statistical analysis of an internal wheat yield trial显示文摘 | CROSSA J Fox P N Pfeiffer W H | 1991 | Theor Appl Genet1991，81，： | 1 |
| 5 | Dairy chemistry and biochemistry 显示文摘 | FOX P F MCSWEENEY P L H | 1998 | Blackie Academic Professi-onal1998，，： | 1 |
| 6 | The effect of N fertilizer source on grain yield, N uptake, soil pH and lime requirement in No-Till Corn 显示文摘 | Fox P H Hoffman L D | 1981 | Agronomy Journal1981，73，5： | 1 |
| 7 | Helical (spiral)CT of evaluation of acute abdomen显示文摘 | Zemen R K Fox S H Silverman P M | 1993 | A JR1993，160，： | 1 |
| 8 | Damage mechanisms of coated systems under thermomechanical fatigue显示文摘 | Zhang Y H Withers P J Fox M D | 1999 | Materials Science and Technology1999，15，： | 1 |
| 9 | Trim5 a accelerates degradation of cytosolic capsid associated with productive HIV-1 Entry 显示文摘 | Chatterji U Bobardt M Gaskill P Sheeter D Fox H Gallay R 2006 | 2006 | J Biol Chem2006，281，37： | 1 |
| 10 | Use of a chlorophyll meter to predict side-dress nitrogen requirement for maize显示文摘 | Piekielek W P Fox R H | 1992 | Agron J1992，84，： | 1 |
| 11 | Tunable-focus Liquid Lens Controlled Using Aservo Motor显示文摘 | Ren H Fox D Anderson P A | 2006 | OPTICS EXPRESS2006，14，18： | 1 |
| 12 | Accelerated Ripening of Cheddar Cheese at Elevated Temperatures显示文摘 | FORKERTSMA B FOX P F MCSWEENEY P L H | 1999 | Dairy Journal1999，6，： | 1 |
| 13 | Chemical methods for the characterization of proteolysis in cheese during ripening显示文摘 | MCSWEENEY P L H FOX P F | 1997 | Le Lait1997，77，1： | 1 |
| 14 | Using a chlorophyll meter to predict nitrogen fertilizer needs of winter wheat 显示文摘 | Fox R H Piekielek W P Macneal K M | 1994 | Communications in Soil Science and Plant Analysis1994，25，34： | 1 |
| 15 | Effect of progressive failure on measured shear strength of geomembrane/GCL interface 显示文摘 | FOX P J ROBERT H K | 2008 | Journal of Geotechnical and Geoenvironmental Engineering2008，134，4： | 1 |
| 16 | Use of chlorophyll meter to predict sidedress nitrogen requirements for maize显示文摘 | Piekkielek W P Fox R H | | 0，，： | 1 |
| 17 | Bearing capacity of geosynthetic clay liners for cover soils of varying particle size显示文摘 | Fox P J De Battista D J Chen S H | 1996 | Geosynth Int1996，3，4： | 1 |
| 18 | Heat stability of milk: pH - dependent dissociation of micellar - casein on heating milk at ultra high temperatures显示文摘 | Singh H Fox P F | 1985 | Journal of Dairy Research1985，52，： | 1 |
| 19 | Evaluation of the tabular feed energy and protein undegradability values of the National Research Council nutrient re- quirements of beef cattle 显示文摘 | TEDESCHI L O FOX D G DOANE P H | 2005 | The Professional Animal Scientist2005，21，： | 1 |
| 20 | An apparently new transmissible disease of cattle 显示文摘 | Olafson P Maccallum A D Fox F H | 1946 | Cornell Vet1946，36，： | 1 |
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