|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia显示文摘AIM: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma. METHODS: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method. RESULTS: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04).considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia. | Carina Pereira Hugo Sousa Paula Ferreira Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，34： | 16 |
| 2 | Gastric cancer in a Caucasian population: Role of pepsinogen C genetic variants显示文摘瞄准:在胃蛋白酶原 C (PGC ) 基因学习插入 / 删除多型性的角色,为胃粘膜的终端区别的一个有效标记,在到胃的损害的开发的危险性。方法:没有肿瘤的疾病的证据,学习与已知的胃的损害的 99 件样品和 127 件样品被执行。PCR 被采用, 6 多态的等位基因被放大:等位基因 1 (510 bp ) ,等位基因 2 (480 bp ) ,等位基因 3/4 (450/460 bp ) ,等位基因 5 (400 bp ) 并且等位基因 6 (310 bp ) 。结果:我们的结果表明等位基因 6 搬运人似乎对任何胃的损害的发展有保护(或 = 0.34;P<0.001 ) ,与象萎缩或肠的组织变形那样的胃的腺癌联系的 non-dysplastic 损害(或 = 0.28;P<0.001 ) 或侵略 GC (或 = 0.39;P = 0.004 ) 。结论:我们的学习表明等位基因 6 搬运人地位在胃的损害的发展有一个保护的角色,可能由于它有 PGC 的更高的表示的协会。而且,在控制组的等位基因 6 搬运人的频率比在亚洲人口获得了高是远的,它可能代表在白种人和亚洲人口之间的基因差距。 | Ana L Pinto-Correia Hugo Sousa Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，31： | 6 |
| 3 | Association between EGF +61A/G polymorphism and gastric cancer in Caucasians显示文摘AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men. | Ana Paula Araújo Bruno M Costa Ana L Pinto-Correia Maria Fragoso Paula Ferreira Mário Dinis-Ribeiro Sandra Costa Rui M Reis Rui Medeiros | 2011 | World Journal of Gastroenterology2011，17，4： | 3 |
| 4 | α-Chymotrypsin stabilization by chemical Conjugation with O-carboxymethyl-poly-β-cyclodextrin显示文摘 | Fernandez M Villalonga M L Fragoso A | 2004 | process Biochemistry2004，39，： | 1 |
| 5 | The risk of developing cervical cancer in Mexican women is associated to CYP1A1 Msp I polymorphism显示文摘 | Juarez-Cedillo T Vallejo M Fragoso JM | 2007 | Eur J Cancer2007，43，10： | 1 |
| 6 | Gastric emptying and antireflux surgery显示文摘 | Estevao-Costa J Fragoso AC Prata MJ Campos M Trindade E Dias JA | 2011 | Pediatr Surg Int2011，27，4： | 1 |
| 7 | A new highly effective antieystieercosis vaccine expressed in transgenic papaya 显示文摘 | Hemandez M Cabrera-Ponce JL Fragoso G | 2007 | Vaccine2007，25，21： | 1 |
| 8 | Isolation and functional characterization of a cotton ubiquitiuation-related promoter and 5'UTR that drives high levels of expression in root and flower tissues显示文摘 | Viana A A Fragoso R R Guimaraes L M | 2011 | BMC Biotechnol2011，11，： | 1 |
| 9 | Impregnation and osmotic dehydration of some fruits:effect of the vacuum pressure and syrup concentration显示文摘 | PAZ H M FRAGOSO A V MALO A L | | 0，，04： | 1 |
| 10 | Ec- topic ACTH syndrome:our experience with 25 cases 显示文摘 | Salgado LR Fragoso MC Knoepfelmacher M | 2006 | Eur J Endocrinol2006，155，5： | 1 |
| 11 | A variable elimination method to improve the parsimony of MLR models using the successive projections algorithm 显示文摘 | Galvao R K H Araujo M C U Fragoso W D | 2008 | Chemom Intell Lab Syst2008，92，： | 1 |
| 12 | A variable elimination method to improve the parsimony of MLR models using the successive projections algorithm显示文摘 | Galvao R K H Araujo M C U Fragoso WD | 2008 | Chemometrics and Intelligent Laboratory Systems2008，92，1： | 1 |
| 13 | Optimal linear mean square filter for continuous-time jump linear systems 显示文摘 | Fragoso M D Costa O L V Baczynski J | 2005 | IEEE Transactions on Automatic Control2005，50，9： | 1 |
| 14 | Effects of an antiexospore monoclonal antibody on microsporidial development in vitro显示文摘 | Enriquez FJ Wagner G Fragoso M | 1998 | Parasitology1998，117，6： | 1 |
| 15 | Effects of an anti-exospore monoclonal antibody on Microsporidial de- velopment in vitro显示文摘 | Enriquez F J Wagner G Fragoso M | 1998 | Parasitology1998，117，06： | 1 |
| 16 | Gastric emptying and antireflux surgery显示文摘 | Estevo-Costa J Fragoso AC Prata M J | 2011 | Pediatr Surg Int2011，27，4： | 1 |
| 17 | H∞ control for linear systems with Markovian jumping parameters显示文摘 | De Souza C E Fragoso M D | 1993 | Contr Theory Adv Technol1993，9，： | 1 |
| 18 | Statistical-dynami- cal modeling of the cloud-to-ground lightning activity in Por- tugal 显示文摘 | Sousa J F Fragoso M Mendes S et 81 | 2013 | Atmospheric Research2013，13，2133： | 1 |
| 19 | Stability results for discrete-time linear systems with Markovian jumping parameters 显示文摘 | Costa O L V Fragoso M D | 1993 | Journal of Mathematical Analysis and Applications1993，179，1： | 1 |
| 20 | Multiple sclerosis starting before the age of 18 years: the Brazilian experience 显示文摘 | FRAGOSO Y D FERREIRA M L MORALES NDE M | 2013 | Arq Neuropsiquiatr2013，71，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员