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| 1 | Endoscopic ultrasound staging for early esophageal cancer: Are we denying patients neoadjuvant chemo-radiation?显示文摘AIM To evaluate the accuracy of endoscopic ultrasound(EUS) in early esophageal cancer(EC) performed in a highvolume tertiary cancer center. METHODS A retrospective review of patients undergoing esophagectomy was performed and patients with c T1 N0 and c T2 N0 esophageal cancer by EUS were evaluated. Patient demographics, tumor characteristics, and treatment were reviewed. EUS staging was compared to surgical pathology to determine accuracy of EUS. Descriptive statistics was used to describe the cohort. Student's t test and Fisher's exact test or χ~2 test was used to compare variables. Logistic regression analysis was used to determine if clinical variables such as tumor location and tumor histology were associated with EUS accuracy.RESULTS Between 2000 and 2015, 139 patients with clinical stage Ⅰ or Ⅱ?A esophageal cancer undergoing esophagectomy were identified. There were 25(18%) female and 114(82%) male patients. The tumor location included the middle third of the esophagus in 11(8%) and lower third and gastroesophageal junction in 128(92%) patients. Ninety-three percent of patients had adenocarcinoma. Preoperative EUS matched the final surgical pathology in 73/139 patients for a concordance rate of 53%. Twenty-nine patients(21%) were under-staged by EUS; of those, 19(14%) had unrecognized nodal disease. Positron emission tomography(PET) was used in addition to EUS for clinical staging in 62/139 patients. Occult nodal disease was only found in 4 of 62 patients(6%) in whom both EUS and PET were negative for nodal involvement. CONCLUSION EUS is less accurate in early EC and endoscopic mucosal resection might be useful in certain settings. The addition of PET to EUS improves staging accuracy. | Carrie Luu Marisa Amaral Jason Klapman Cynthia Harris Khaldoun Almhanna Sarah Hoffe Jessica Frakes Jose M Pimiento Jacques P Fontaine | 2017 | World Journal of Gastroenterology2017，23，46： | 8 |
| 2 | 利用黄土中的碳同位素半定量地重建古温度显示文摘在相对稳定的气候阶段,土壤中的CO2与其中的碳酸盐之间处于同位素平衡状态,这意味着二者的碳同位素分馏值可作为地质温度计估算古温度。对中国洛川黄土剖面的10组黄土-古土壤序列L1-1—S8同时做了碳酸盐和有机质的碳同位素分析。由于这些地层单元可以与深海氧同位素记录的2—21阶段对比,其中L1-1—L2可与南极Vostok冰心的大气CO2浓度记录对比,由此通过相关分析确定了各地层形成时的平均大气CO2浓度及其δ13C值,再根据Cerling模型,用有机质δ13C值代替土壤呼吸CO2的δ13C,算出土壤CO2的δ13C值。将该值与次生碳酸盐的δ13C值代入Deines分馏方程可算出各地层单元的古温度。该温度代表了平均深度约30cm处的土壤温度,相当于当时的夏季大气温度。所有数据与黄土-古土壤地层学记录的气候变化吻合,定量地反映了近800ka来黄土高原古气候的变化。 | 卢玉东 孙建中 李同录 张骏 Frakes L A | 2005 | 海洋地质与第四纪地质2005，25，3： | 5 |
| 3 | Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization显示文摘AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization.METHODS We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients wereseen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control(LLC), distant liver control(DLC), time to distant metastases(DM), progression free survival(PFS) and overall survival(OS).RESULTS The majority of patients were males(n = 25, 74%), and had Child Pugh Class A(n = 31, 91%), with a median age of 68 years(46-84 years). FDG-avid disease was found in 19(56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC(P = 0.02). Median follow up of patients following radioembolization was 12 months(1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS(P < 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS(all P < 0.05).CONCLUSION In this retrospective study, pre-treatment HCC FDGavidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization. | Yazan Abuodeh Arash O Naghavi Kamran A Ahmed Puja S Venkat Youngchul Kim Bela Kis Junsung Choi Benjamin Biebel Jennifer Sweeney Daniel A Anaya Richard Kim Mokenge Malafa Jessica M Frakes Sarah E Hoffe Ghassan El-Haddad | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 4 | Management of borderline resectable pancreatic cancer显示文摘Pancreatic cancer is the fourth most common cause of cancer death in the United States. Surgery remains the only curative option; however only 20% of the patients have resectable disease at the time of initialpresentation. The definition of borderline resectable pancreatic cancer is not uniform but generally denotes to regional vessel involvement that makes it unlikely to have negative surgical margins. The accurate staging of pancreatic cancer requires triple phase computed tomography or magnetic resonance imaging of the pancreas. Management of patients with borderline resectable pancreatic cancer remains unclear. The data for treatment of these patients is primarily derived from retrospective single institution experience. The prospective trials have been plagued by small numbers and poor accrual. Neoadjuvant therapy is recommended and typically consists of chemotherapy and radiation therapy. The chemotherapeutic regimens continue to evolve along with type and dose of radiation therapy. Gemcitabine or 5-fluorouracil based chemotherapeutic combinations are administered. The type and dose of radiation vary among different institutions. With neoadjuvant treatment, approximately 50% of the patients are able to undergo surgical resections with negative margins obtained in greater than 80% of the patients. Newer trials are attempting to standardize the definition of borderline resectable pancreatic cancer and treatment regimens. In this review, we outline the definition, imaging requirements and management of patients with borderline resectable pancreatic cancer. | Amit Mahipal Jessica Frakes Sarah Hoffe Richard Kim | 2015 | World Journal of Gastrointestinal Oncology2015，7，10： | 3 |
| 5 | 利用黄土中碳同位素推断古植被类型显示文摘Carbon isotope of loess through S0 to S 11 at luochuan section in Shaanxi Province were experimented.The curve of δ 13C compares well to the oxygen isotope curves of deep sea sediments from DSDP607 drill.There is obviously negative peak of δ 13C within S5 paleosol where the content of δ 13C is-16.615‰,that shows the climatic optimum,and the vegetation during the period is likely forest.Comparing with the pollen analysis,the vegetation type of paleosol S0,S1,S4,S8,S9 which δ 13C content is-5.85‰~-10.00‰,is forest-grass.δ 13C content of paleosol S2、S3、S6、S7 is-8.72‰~-6.95‰,their vegetation is grass.The loess layer L1、L2、L5、L6、L8、L9 represent the severe cold-dry glacial period with δ 13C content of-3.7‰~-2.27‰,their vegetation belonging to steppe-desert. | 卢玉东 孙建中 李佩成 Frakes L A | 2007 | 林业科学2007，43，8： | 2 |
| 6 | 挤压伤的病理生理学特征及目前的治疗手段显示文摘挤压综合征,也叫创伤性横纹肌溶解症,于1910年由德国作者首先报道,他们发现埋在建筑废墟下的士兵被救出后通常出现以下症状:肌肉疼痛、四肢无力以及棕色尿。直到20世纪40年代,针对在伦敦遭受空袭后四肢被压的伤员所表现出的症状,’肾病学家Bywaters和Beal提出了挤压综合征的明确定义:休克、肢体肿胀、茶色尿以及伴随出现的肾衰竭。横纹肌溶解症通常导致肌红蛋白尿性肾衰竭、电解质紊乱、酸中毒以及血容量不足;这些症状后来就成为大家所熟知的挤压综合征。本文回顾性分析了挤压综合征的流行病学特征、病理生理学特征、诊断以及早期治疗。 | Michael Sahjian Michael Frakes 伍明俊(节译) 郑忠伟(译校) | 2008 | 中国输血杂志2008，21，8： | 2 |
| 7 | Software Reuse:Metrics and Models显示文摘 | Carol Terry | 1996 | ACM Computing Surveys1996，，6： | 1 |
| 8 | Software Reuse Research:Status and Future显示文摘 | Frakes WB Kang K | 2005 | IEEE Transactions on Software Engineering2005，31，7： | 1 |
| 9 | Changes in expression of sensory organ-specific mieroRNAs in rat dorsal root ganglia in asso- ciation with mechanical hypersensitivity induced by spinal nerve ligation显示文摘 | Aldrich BT Frakes EP Kasuya J | 2009 | Neuroscienee2009，164，： | 1 |
| 10 | Trace fossils in the Lower Beacon sediments (Devonian),Darwin mountains,Southern Victoria Land,Antarctica显示文摘 | Gevers T W Frakes L A Edwards L N | 1971 | Journal of Paleontology1971，45，1： | 1 |
| 11 | Representing reusable software显示文摘 | Frakes W B Ganeel P B | 1990 | Information and Software Technology1990，32，10： | 1 |
| 12 | Biliary pancreatitis:a review em-phasizing appropriate edoscopic intervention显示文摘 | Frakes JT | 1999 | J Clin Gastroenterol1999，28，2： | 1 |
| 13 | An empirical study of representation methods for reusable software components 显示文摘 | FRAKES W B POLE T P | 1994 | IEEE Transactions on Software Engineering1994，20，8： | 1 |
| 14 | Software reuse research: Status and future显示文摘 | Frakes W B Kang K C | 2005 | IEEE Transactions on Software Engineering2005，31，7： | 1 |
| 15 | Segment adaptive gradient angle interpolat ion显示文摘 | Zwart C M Frakes D H | 2013 | Image Processing IEEE Transactions on2013，22，8： | 1 |
| 16 | Representing reusable sofeware显示文摘 | Gandel P B | 1990 | Information and software technology1990，32，10： | 1 |
| 17 | The impact of pharmaceutical care practice on the practitioner and the patient in the ambulatory practice setting: twenty-five years of experience显示文摘 | Strand LM Cipolle RJ Morley PC Frakes MJ | 2004 | Curr Pharm Des2004，10，： | 1 |
| 18 | Origin of manganese giants:Sea level change and anoxic-oxic history显示文摘 | Frakes L A Bolton B R | 1984 | Geology1984，12，1： | 1 |
| 19 | An empirical study of representation methods for reusable software components显示文摘 | FRAKES W B POLE T P | 1994 | IEEE Transactions on Software Engineering1994，120，8： | 1 |
| 20 | Software reuse research:Status and future显示文摘 | Frakes William B Kang Kyo | 2005 | IEEE Transactions on Software Engineering2005，31，7： | 1 |
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