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| 1 | Knowledge, attitudes and practices with regard to the presence, transmission, impact, and control of cystic echinococcosis in Sidi Kacem Province, Morocco显示文摘Background:This study is a component of a large research project on five major neglected zoonotic diseases(NZDs)including cystic echinococcosis and was undertaken in the Province of Sidi Kacem over a period of four years(April 2009-March 2013).Methods:Questionnaires were administered at community level in a total of 27 communes and visits were made to all of the 10 abattoirs situated in the Province,to collect qualitative data on determinants of transmission for disease in humans and animals.More specifically,community knowledge,attitudes and practices related to cystic echinococcosis were assessed,as well as the extent to which local customs and behaviours may promote transmission.Abattoir infrastructure and practices,and their role in perpetuating disease transmission were also critically evaluated.Results:The results show that only 50%of people have heard of the disease,and of those,only 21%are aware of the dog’s role in disease transmission.Sixty-seven per cent of respondents stated that dogs are fed ruminant organs deemed unfit for human consumption.Owned dogs have access to the family home,including the kitchen,in 39%of households.The extent of this close proximity between humans and animals is even more pertinent when one considers that dogs are omnipresent in the community,with an average of 1.8 dogs owned per household.The unrestricted access of dogs to abattoirs is a huge issue,which further promotes disease transmission.Conclusion:This study would suggest that the high prevalence of cystic echinococcosis in humans and animals in Morocco is largely due to three factors:1)abundance of dogs 2)engagement in risky behaviour of the local population and 3)poor abattoir infrastructure and practices.This has serious implications in terms of the socio-economic impact of the disease,especially for rural poor communities. | Ikhlass El Berbri Marie J.Ducrotoy Anne-Françoise Petavy Ouaffa Fassifihri Alexra PShaw Mohammed Bouslikhane Franck Boue Susan C.Welburn Allal Dakkak | 2015 | Infectious Diseases of Poverty2015，4，1： | 4 |
| 2 | Early Administration of Azathioprine vs Conventional Management of Crohn’s Disease: a Randomized Controlled Trial显示文摘 | Jacques Cosnes Anne Bourrier David Laharie Stéphane Nahon Yoram Bouhnik Franck Carbonnel Matthieu Allez Jean-Louis Dupas Jean-Marie Reimund Guillaume Savoye Pauline Jouet Jacques Moreau Jean-Yves Mary Jean-Frédéric Colombel | 2013 | Gastroenterology2013，，： | 2 |
| 3 | Vitamin D reduces the inflammatory response and restores glucose uptake in adipocytes显示文摘 | Julie Marcotorchino Erwan Gouranton Beatrice Romier Franck Tourniaire Julien Astier Christiane Malezet Marie‐Josèphe Amiot Jean‐Fran?ois Landrier | 2012 | Food Res2012，，12： | 2 |
| 4 | Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort显示文摘 | Sabrina Schlesinger Krasimira Aleksandrova Tobias Pischon Veronika Fedirko Mazda Jenab Elisabeth Trepo Paolo Boffetta Christina C. Dahm Kim Overvad Anne Tj?nneland Jytte Halkj?r Guy Fagherazzi Marie‐Christine Boutron‐Ruault Franck Carbonnel Rudolf Kaaks A | 2012 | Int J Cancer2012，，3： | 1 |
| 5 | Network theory- based analysis of risk interactions in large engineering projects 显示文摘 | Chao Fang Franck Marie Enrico Zio | 2012 | Reliability Engineering and System Safety2012，，： | 1 |
| 6 | The expression of Twist has an impact on survival in human bladder cancer and is influenced by the smoking status显示文摘 | Marie E. Fondrevelle Bernadette Kantelip Robert E. Reiter Dominique K. Chopin Jean P. Thiery Franck Monnien Hugues Bittard Hervé Wallerand | 2009 | Urologic Oncology: Seminars and Original Investigations2009，，3： | 1 |
| 7 | Altered erythrocyte n-3 fatty acids in mediterranean patients with coronary artery disease 显示文摘 | Franck P Jean M Marie D | 2001 | Internatinal Journal of Cardiology2001，78，： | 1 |
| 8 | A simulation-based risk network model for decision support in project risk management显示文摘 | Fang Chao Marie Franck | 2012 | Decision Support Systems2012，52，3： | 1 |
| 9 | High frequency of CD34+CD38-/low immature leukemia cells is correlated with unfavorable prognosis in acute myeloid leukemia显示文摘AIM To evaluate the importance of the CD34+CD38-cell population when compared to the CD34+CD38+/low and CD34+CD38+/high leukemic cell sub-populations and to determine its correlations with leukemia characteristics and known prognostic factors, as well as with response to therapy and survival.METHODS Two hundred bone marrow samples were obtained at diagnosis from 200 consecutive patients with newly diagnosed acute myeloid leukemia(AML) were studied between September 2008 and December 2010 at our Institution(Hematology Department, Lyon, France). The CD34/CD38 cell profile was analyzed by multiparameter flowcytometry approach using 8 C panels and FACS CANTO and Diva software(BD Bioscience).RESULTS We analyzed CD34 and CD38 expression in bone marrow samples of 200 AML patients at diagnosis, and investigated the prognostic value of the most immature CD34+CD38-population. Using a cut-off value of 1% of CD34+CD38-from total 'bulk leukemic cells' we found that a high(> 1%) level of CD34+CD38-blasts at diagnosis was correlated with advanced age, adverse cytogenetics as well as with a lower rate of complete response after induction and shorter disease-free survival. In a multivariate analysis considering age, leukocytosis, the % of CD34+ blasts cells and the standardized cytogenetic and molecular risk subgroups, a percentage of CD34+CD38-leukemic cells > 1% was an independent predictor of DFS [HR = 2.8(1.02-7.73), P = 0.04] and OS [HR = 2.65(1.09-6.43), P = 0.03].CONCLUSION Taken together, these results show that a CD34/CD38 'backbone' for leukemic cell analysis by multicolour flowcytometry at diagnosis provides useful prognostic information. | Adriana Plesa Charles Dumontet Eve Mattei Ines Tagoug Sandrine Hayette Pierre Sujobert Isabelle Tigaud Marie Pierre Pages Youcef Chelghoum Fiorenza Baracco Helene Labussierre Sophie Ducastelle Etienne Paubelle Franck Emmanuel Nicolini Mohamed Elhamri Lydia Campos Claudiu Plesa Stéphane Morisset Gilles Salles Yves Bertrand Mauricette Michallet Xavier Thomas | 2017 | World Journal of Stem Cells2017，9，12： | 1 |
| 10 | Impact of STAT3 Phosphorylation on the Clinical Effectiveness of Anti-EGFR–Based Therapy in Patients With Metastatic Colorectal Cancer显示文摘 | Erion Dobi Franck Monnien Stefano Kim Arben Ivanaj Thiery N’Guyen Martin Demarchi Olivier Adotevi Antoine Thierry-Vuillemin Marie Jary Bernadette Kantelip Xavier Pivot Yann Godet Severine Valmary Degano Christophe Borg | 2012 | Clinical Colorectal Cancer2012，，： | 1 |
| 11 | The influ- ence of cellulose content on tensile strength in tree roots 显示文摘 | Marie Genet Alexia Stokes Franck Salin | 2005 | Plant and Soil2005，278，： | 1 |
| 12 | An integrated framework for risk resp- onse planning under resource constraints in large engineering prejects显示文摘 | Chao Fang Franck Marie Min Xie | 2013 | IEEE Transactions on Engineering Management2013，60，3： | 1 |
| 13 | In vitro and in vivo studies of lead immobilization by synthetic hydroxyapatite显示文摘 | Nathalie Arnich Marie Claire Lanbers Franck Laurensot | 2003 | Environmental Pollution2003，124，： | 1 |
| 14 | Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer显示文摘 | Gabriela Bindea Bernhard Mlecnik Marie Tosolini Amos Kirilovsky Maximilian Waldner Anna C. Obenauf Helen Angell Tessa Fredriksen Lucie Lafontaine Anne Berger Patrick Bruneval Wolf Herman Fridman Christoph Becker Franck Pagès Michael R. Speicher Zlatko Tra | 2013 | Immunity2013，，4： | 1 |
| 15 | The Influence of Cellulose Content on Tensile Strength in Tree Roots显示文摘 | Marie Genet Alexia Stokes Franck Salin Slobodan B. Mickovski Thierry Fourcaud Jean-Fran?ois Dumail Rens Beek | 2005 | Plant and Soil (-)2005，，1： | 1 |
| 16 | Using A Delphi Process and the Analytic Hierarchy Process (AHP) to Evaluate the Complexity of Projects显示文摘 | Ludovic Alexandre Vidal Franck Marie Jean Claude Bocquet | 2011 | Expert Systems with Applications2011，38，5： | 1 |
| 17 | The influence of cellulose content on tensile strength in trees roots显示文摘 | Marie G Alexia S Franck S | 2005 | Plant and Soil2005，278，12： | 1 |
| 18 | Zoonotic aspects of Mycobacterium bovis and Mycobacterium avium-intracellulare complex (MAC)显示文摘 | Franck BIETa Maria Laura Boschirolib Marie Fran oise Thorelb | 2005 | Vet Res2005，36，： | 1 |
| 19 | ClneG0: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks 显示文摘 | Gabriela B Bernhard M Hubert H Pornpimol C Marie T Amos K Wolf-Herman F Franck P Zlatko T Jerome G | 2009 | Bioinformatics2009，25，8： | 1 |
| 20 | The Influence of Cellulose Content on Tensile Strength in Tree Roots显示文摘 | Marie Genet Alexia Stokes Franck Salin Slobodan B. Mickovski Thierry Fourcaud Jean-Fran?ois Dumail Rens Beek | 2005 | Plant and Soil (-)2005，，1： | 1 |
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