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| 1 | Current medical treatment of estrogen receptor-positive breast cancer显示文摘Approximately 80% of breast cancers(BC) are estrogen receptor(ER)-positive and thus endocrine therapy(ET) should be considered complementary to surgery in the majority of patients. The advantages of oophorectomy, adrenalectomy and hypophysectomy in women with advanced BC have been demonstrated many years ago, and currently ET consist of(1) ovarian function suppression(OFS), usually obtained using gonadotropinreleasing hormone agonists(Gn RHa);(2) selective estrogen receptor modulators or down-regulators(SERMs or SERDs); and(3) aromatase inhibitors(AIs), or a combination of two or more drugs. For patients aged less than 50 years and ER+ BC, there is no conclusive evidence that the combination of OFS and SERMs(i.e., tamoxifen) or chemotherapy is superior to OFS alone. Tamoxifen users exhibit a reduced risk of BC, both invasive and in situ, especially during the first 5 years of therapy, and extending the treatment to 10 years further reduced the risk of recurrences. SERDs(i.e., fulvestrant) are especially useful in the neoadjuvant treatment of advanced BC, alone or in combination with either cytotoxic agents or AIs. There are two types of AIs: type Ⅰ are permanent steroidal inhibitors of aromatase, while type Ⅱ are reversible nonsteroidal inhibitors. Several studies demonstrated the superiority of the third-generation AIs(i.e., anastrozole and letrozole) compared with tamoxifen, and adjuvant therapy with AIs reduces the recurrence risk especially in patients with advanced BC. Unfortunately, some cancers are or became ET-resistant, and thus other drugs have been suggested in combination with SERMs or AIs, including cyclin-dependent kinase 4/6 inhibitors(palbociclib) and mammalian target of rapamycin(m TOR) inhibitors, such as everolimus. Further studies are required to confirm their real usefulness. | Franco Lumachi Davide A Santeufemia Stefano MM Basso | 2015 | World Journal of Biological Chemistry2015，6，3： | 16 |
| 2 | Optimization of room-and-pillar dimensions using automated numerical models显示文摘This paper presents an optimization methodology for the geometric configuration of a room–and–pillar mining project,considering safety and operational restrictions while maximizing ore recovery.An underground manganese mine was chosen as a case study to investigate the capabilities of the presented methodology.A software package(OPTIMINE)was implemented to address the computational demand in an automated manner.Three–dimensional finite difference analyses were performed in FLAC3D and used as implicit functions to consider safety in terms of the factor of safety and room convergence.The obtained results showed that recovery could be increased from 44%to more than 80%in a safe manner. | Gian Franco Napa-García Tais Renata Camara Vidal Félix Navarro Torres | 2019 | International Journal of Mining Science and Technology2019，29，5： | 2 |
| 3 | Management approaches to adrenal incidentalomas显示文摘 | Franco M Giorgio A | 2000 | Endocrinol Metab Clin North Am2000，29，1： | 1 |
| 4 | Bipolar transurethral resection of prostate: clinical and urodynamic evaluation显示文摘 | Iori F Franco G Leonardo C Laurenti C Tubaro A D-Amico F | 2008 | Urology2008，71，： | 1 |
| 5 | Cervical cancer: epidemiology,prevention and the role of human papillomavirus infection 显示文摘 | FRANCO E L DUARTEFRANCO E FERENCZY A | 2001 | CMAJ2001，164，7： | 1 |
| 6 | Time-dependent strength and creep in masonry 显示文摘 | Parsekian G A Franco L S | 2006 | TMS Journal2006，24，1： | 1 |
| 7 | Postcolumn excitation of aflatoxins using cyclodextrins in liquid chromatography for food analysis显示文摘 | Cepeda A Franco CM Fente CA | 1996 | J Chromatogr A1996，721，1： | 1 |
| 8 | Cervical cancer:epidemiology,prevention and the role of HPV infection显示文摘 | FRANCO E L DUARTE-FRANCO E FERENCZY A | 2001 | CMAJ2001，164，7： | 1 |
| 9 | A multicenter,randomized,double-blind clinical trial examining the effect of oral human recombinant epidermal growth factor on the healing of duodenal ulcers显示文摘 | Palomino A Haedo W Franco S | 2000 | Scand J Gastroenterol2000，35，10： | 1 |
| 10 | A phase Ⅱ study of liposomal lurtotecan (OSI-211) in patients with topotecan resistant ovarian cancer显示文摘 | Michael VS Franco M Allan A | 2004 | Gynecol Oncol2004，93，1： | 1 |
| 11 | Rotavirus vac- cines: recent developments and future considerations 显示文摘 | ANGEL J FRANCO M A GREENBERG H B | 2007 | Nat Rev Microbiol2007，5，7： | 1 |
| 12 | 3,5-Dimethylphenylcar- barnates of amylose, chitosan and cellulose bonded on silica gel Com- parison of their chiral recognition abilities as high-performance liquid chromatography chiral stationary phases显示文摘 | Franco P Senso A Minguillo'na C | 1998 | J Chromatography A1998，，： | 1 |
| 13 | Therapy -induced acute recruitment of circulating endothelial progenitor cells to tumors 显示文摘 | Shaked Y Ciarrocchi A Franco M | 2006 | Science2006，313，： | 1 |
| 14 | Recent expansion of dengue virus serotype 3 in West Africa 显示文摘 | Franco L Di Caro A Carletti F | 2010 | Euro Surveill2010，15，19： | 1 |
| 15 | Electro oxidation of methanol and ethanol on Pt-Ru/C and Pt-Ru-Mo/C electrocatalysts prepared by Bonnemann' s method 显示文摘 | Oliveira N A Franco G E Arico E | 2003 | Journal of the European Ceramic Society2003，23，： | 1 |
| 16 | Beneficial effects of HLA class Ⅱ incompatibility in living donor liver transplantation显示文摘 | Campos J Quijano Y Franco A | 2003 | Transplant Proc2003，35，5： | 1 |
| 17 | Simple and sensitive high-performance liquid chromatography fluorescence method for the determination of citrinin-application to the analysis of fungal cultures and cheese extracts显示文摘 | FRANCO C M FENTE C A VAZQUEZ B | 1996 | Journal of Chromatography1996，723，： | 1 |
| 18 | Geostatistical modelling of heavy metal contamination in the topsoil of Guadiamar river margins ( S Spain) using a stochastic simulation technique 显示文摘 | Franco C Soares A Delgado J | 2006 | Geoderma2006，136，34： | 1 |
| 19 | Natural antioxidants from residual sources显示文摘 | MOURE A CRUZ J M FRANCO D | 2001 | Food Chemistry2001，72，： | 1 |
| 20 | Follicular loss in endoscopic surgery for ovarian endometriosis:quantitative and qualitative observations显示文摘 | Romualdi D Franco Zannoni G Lanzone A | | 0，，02： | 1 |
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