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| 1 | Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis显示文摘电压依赖者阴离子隧道(VDAC ) 1 是 mitochondrial 的主要隧道外部膜(妈妈) 和它被建议了是渗透转变毛孔(PTP ) 的部分, mitochondrial 渗透转变(MPT ) 的一个通常认为的 multiprotein 建筑群候选人代理人。在单个实时房间水平工作,我们发现 VDAC1 的 overexpression 在 mitochondrial 触发 MPT 内部膜(MIM ) 。相反地,在 MPT 的抑制的 silencing VDAC1 表示结果由导致亚硒酸盐的氧化应力引起了。这 MOM-MIM 串音被 Cyclosporin A 和 mitochondrial Cyclophilin D,然而并非由 Bcl-2 和 Bcl-XL 调制, PTP 的陈述语气操作。VDAC1 依赖的 MPT 雇佣包含反应的氧种类和 p38-MAPK 的一个积极反馈环,并且在第二包括 Bax 激活,细胞色素 c 版本和 caspase 触发正规 apoptotic 回答 3 激活。我们的数据因此支持在 MOM 包含 VDAC1 的 PTP 建筑群的一个模型,并且显示 VDAC1 依赖的 MPT 是在氧化导致压力的 apoptosis 起一个原因的作用的在上游的机制。 | Flora Tomasello Angela Messina Lydia Lartigue Laura Schembri Chantal Medina Simona Reina Didier Thoraval Marc Crouzet Frangois Ichas Vito De Pinto Francesca De Giorgi | 2009 | Cell Research2009，19，12： | 6 |
| 2 | A Molecular Framework for the Control of Adventitious Rooting by TIR1/AFB2-Aux/IAADependent Auxin Signaling in Arabidopsis显示文摘In Arabidopsis thaliana,canonical auxin-dependent gene regulation is mediated by 23 transcription factors from the AUXIN RESPONSE FACTOR(ARF)family that interact with auxin/indole acetic acid repressors(Aux/IAAs),which themselves form co-receptor complexes with one of six TRANSPORT INHIBITOR*!/AUXIN-SIGNALLING F-BOX(TIR1/AFB)proteins.Different combinations of co-receptors drive specific sensing outputs,allowing auxin to control a myriad of processes.ARF6 and ARF8 are positive regulators of adventitious root initiation upstream of jasmonate,but the exact auxin co-receptor complexes controlling the transcriptional activity of these proteins has remained unknown.Here,using loss-of-function mutants we show that three Aux/IAA genes,IAA6,IAA9,and IAA17,act additively in the control of adventitious root(AR)initiation.These three IAA proteins interact with ARF6 and/or ARF8 and likely repress their activity in AR development.We show that TIR1 and AFB2 are positive regulators of AR formation and TIR1 plays a dual role in the control of jasmonic acid(JA)biosynthesis and conjugation,as several JA biosynthesis genes are up-regulated in the tir1-1 mutant.These results lead us to propose that in the presence of auxin,TIR1 and AFB2 form specific sensing complexes with IAA6,IAA9,and/or IAA17 to modulate JA homeostasis and control AR initiation. | Abdellah Lakehal Salma Chaabouni Emilie Cavel Rozenn Le Hir Alok Ranjan Zahra Raneshan Ondrej Novak Daniel IPacurar Irene Perrone Frangois Jobert Laurent Gutierrez Laszlo Bako Catherine Bellini | 2019 | Molecular Plant2019，12，11： | 5 |
| 3 | C e f otaximeprevents microbial contamination a n d i m p r o v e smicrospore e m b r y o g e n e s i s in w h e a t a n d triticale 显示文摘 | M u h a m m a d A Frangois E H a r p i n d e r R | | Plant Cell R e p0，32，10： | 1 |
| 4 | Protracted release of the LHRH agonist avorelin (MF 6001) from two depot formulations in dogs and men显示文摘 | FRANGOIS B HELENE T SANDRINE D | 1997 | Lett Pept Sci1997，4，46： | 1 |
| 5 | New reduction procedures and lower bounds for the two-dimensional bin packing problem with fixed orientation 显示文摘 | Jacques Carlier Frangois Clautiaux Aziz Moukrim | 2007 | Computer & Operations Research2007，34，： | 1 |
| 6 | The role of multilateral organizations and governments in advancing social innovation in health care delivery显示文摘Background:Despite great medical advances and scientific progress over the past century,one billion people globally still lack access to basic health care services.In the context of the 2030 Agenda for Sustainable Development social innovation models aim to provide effective solutions that bridge the health care delivery gap,address equity and create social value.This commentary highlights the roles of multilateral organizations and governments in creating an enabling environment where social innovations can more effectively integrate into health systems to maximize their impact on beneficiaries.Main text:The integration of social innovations into health systems is essential to ensure their sustainability and the wide dissemination of their impact.Effective partnerships,strong engagement with and endorsement by governments and communities,regulations,trust and sometimes willingness are key factors to enhance system integration,replication and dissemination of the models.Three examples of social innovations selected by the Social Innovation in Health Initiative illustrate the importance of engaging with governments and communities in order to link,integrate and synergize their efforts.Key challenges that they encountered,and lessons learnt are highlighted.Multilateral organizations and governments increasingly engage in promoting and supporting the development,testing and dissemination of social innovations to address the health care delivery gap.They play an important role in creating an enabling environment.This includes promoting the concept of social innovation in health care delivery,spreading social innovation approach and lessons learnt,fostering partnerships and leveraging resources,convening communities,health system actors and various stakeholders to work together across disciplines and sectors,and nurturing capacity in countries.Conclusions:Multilateral organizations and local and national governments have a critical role to play in creating an enabling environment where social innovations can flourish.In supporting and disseminating social innovation approach,multilateral organizations and governments have a great opportunity to accelerate Universal Health Coverage and the achievement of the Sustainable Development Goals. | Beatrice Halpaap Rosanna W.Peeling Frangois Bonnici | 2019 | Infectious Diseases of Poverty2019，8，5： | 1 |
| 7 | Ontogeny of the epicranial portion of the dorsal fin in Solea solea and Scophtha]mus maximus ( Teleostei, Pleuroneeti- formes ) 显示文摘 | France Wagemans Frangois Chapleau Andrew Cooper J | 2001 | Ichthyological Research2001，49，1： | 1 |
| 8 | Post-traumatic meningioma: three case reports of this rare condi-tion and a review of the literature 显示文摘 | Frangois P Nodri D Bergemer-Fouquet AM | 2010 | Acta Neurochir(Wien)2010，152，： | 1 |
| 9 | A systematic methodology for the environomic design and synthesis of energy systems combining Process Integration, Life Cycle Assessment and Industrial Ecology 显示文摘 | LEDA GERBER SAMIRA FAZLOLLAHI FRANGOIS MARECHAL | 2013 | Computers & Chemical Engineering2013，59，： | 1 |
| 10 | Impact of plant growth and morphology of sediment concentration on sediment retention efficiency of vegetative filter strips: Flume experiments and VFSMOD modeling显示文摘 | Lambrechts T Frangois S Lutts S | 2014 | Journal of Hydrology2014，511，7： | 1 |
| 11 | Definition of a radiosounding database for sea surface brightness temperature simulations : Application to sea surface temperature retrieval algorithm determination显示文摘 | Frangois C Brisson A Le Borgne P | 2002 | Remote Sensing of Environment2002，81，23： | 1 |
| 12 | Local irradiation not only induces homing of human mesenchymal stem cells at exposed sites but promotes their widespread engraftment to multiple organs: a study of their quantitative distribution after irradiation damage显示文摘 | Frangois S Bensidhoum M Mouiseddine M | 2006 | Stem Cells2006，24，4： | 1 |
| 13 | Housing Market Dynamics: On the Contribution of Income Shocks and Credit Constraints显示文摘 | Frangois Ortalo-Magn6 sven Rady | 2006 | Review of Economic Studies2006，，17： | 1 |
| 14 | A new french standard test method for the design of surfaeings on steel deck bridges 显示文摘 | Frangois Olard Bernard Hdritier Frdddrie Loup etc | 2005 | Road Materials and Pavement Design2005，6，4： | 1 |
| 15 | Response of post-tensioned con- crete beams with unbonded tendons including serviceability and ultimate state显示文摘 | VU N A CASTEL A FRANGOIS R | 2010 | Engineering Structures2010，32，2： | 1 |
| 16 | Influence of Long--Term Corrosion in Chloride Environment on Me- chanical Behavior of RC beam 显示文摘 | VU HIEP DANG RAOUL FRANGOIS | 2013 | Engineering Struc- tures2013，48，： | 1 |
| 17 | Coordinating cascaded surge protection devices: high-low versus low-high显示文摘 | JIH-SHENG Lai FRANGOIS D Martzloff | 1993 | IEEE Transactions on Industry Application1993，29，4： | 1 |
| 18 | Corrosion of the Reinforcement and Its Influence on the Residual Structur- al Performance of A 26- Year--Old Corroded RC Beam 显示文摘 | ZHU WENJUN RAOUL FRANGOIS | 2014 | Construction and Building Materials2014，51，： | 1 |
| 19 | DNA barcoding for ecologists显示文摘 | Alice V Frangois P Pierre T | 2009 | Cell Press2009，24，2： | 1 |
| 20 | Changes in light intensity reveal a major role for carbon balance inArabidopsis responses to high temperature显示文摘 | Frangois Vasseur Florent Pantin Denis Vile | 2011 | Plant cell& environment2011，34，： | 1 |
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