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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | The accuracy and precision of body temperature monitoring methods during regional and general anesthesia显示文摘 | Cattaneo CG Frank SM Hesel TW | 2000 | Anesth Analg2000，90，4： | 1 |
| 3 | The accuracy and precision of body temperature monitoring methods during re- gional and general anesthesia 显示文摘 | Cattaneo CG Frank SM Hesel TW | 2000 | Anesth Analg2000，90，4： | 1 |
| 4 | Recurrence rate of superficial basal cell carcinoma following successful treatment with imiquimod 5% cream: interim 2-year results from an ongoing 5-year follow-up study in Europe显示文摘 | Gollnick H Barona CG Frank RG | 2003 | Eur J Dermatol Genit Tract Dis2003，7，3： | 1 |
| 5 | Recurrence rate of superficial basal cell carcinoma following successful treatment with imiquimod 5% cream:interim 2-year results from an ongoing 5-year follow-up study in Europe显示文摘 | Gollnick H Barona CG Frank RG | 2005 | Eur J Dermatol2005，15，5： | 1 |
| 6 | The accuracy and precision of body temperature monithering methods during regional and general anesthesia显示文摘 | Cattaneo CG Frank SM Hesel TW | 2000 | Anesth Analg2000，9，4： | 1 |
| 7 | Predictors of hypothermia during spinal anesthesia显示文摘 | Frank SM El-Rahmany HK Cattaneo CG | 2000 | Anesthesiology2000，92，5： | 1 |
| 8 | accuracy and precision of body temperature monitoring methods during regional and gen- eral anesthesia显示文摘 | Cattaneo CG Frank SM Hesel TW | 2000 | Anesth Analg2000，90，4： | 1 |
| 9 | Recurrence rate of superficial basal cell carcinoma following treatment with imiquimod 5% cream : conclusion of a 5-year long-term follow-up study in Europe 显示文摘 | Gotlnick H Barnna CG Frank RG | 2008 | Eur J Dermatol2008，18，6： | 1 |
| 10 | The accuracy and precislon of body temperature monitoring methods during regional and general anesthesia显示文摘 | Catlaneo CG Frank SM Hesel TW | 2000 | Anesth Analg2000，90，4： | 1 |
| 11 | Is There a role of vi- tamin D deficieney in type 1 diabetes of children? 显示文摘 | Sharif BM Frank CG Cedric FG | 2010 | Am J Prev Med2010，39，2： | 1 |
| 12 | Social relationships and health: the relative roles of family functioning and social support 显示文摘 | P Franks TL Campbell CG Shields | 1992 | Social Med1992，34，7： | 1 |
| 13 | Optimizing preoperative blood ordering with data acquired from an anesthesia information m- anagement system显示文摘 | Frank SM Rothschild JA Masear CG | 2013 | Anesthesiology2013，118，6： | 1 |
| 14 | Klebsiella pneumoniae subverts the activation of inflammatory responses in a NODl-dependent manner显示文摘 | Regueiro V Moranta D Frank CG | 2011 | Cell Microbiol2011，13，1： | 1 |
| 15 | The accuracy and precision of body temperature monitoring methods during regional and general anesthesia显示文摘 | Cattaneo CG Frank SM Hesel TW | 2000 | Anesth Analg2000，90，4： | 1 |
| 16 | The accuracy and precision of body temperature monitoring methods during regional and general anesthesia 显示文摘 | Cattaneo CG Frank SM Hesel TW | 2000 | Anesth Analg2000，90，4： | 1 |
| 17 | Predictors of hypothermia during spinal anesthesia显示文摘 | Frank SM El-Rahmany HK Cattaneo CG | 2000 | Anesthesiology2000，92，： | 1 |
| 18 | Recurrence rate of superficial basal cell carcinoma following treatment with imiquimod 5% cream:conclusion of a 5-year long-term follow-up study in Europe显示文摘 | Gollnick H Barona CG Frank RG | 2008 | Eur J Dermatol2008，18，6： | 1 |
| 19 | Predictors of hypothemia during spinal anesthesia显示文摘 | Frank SM El-Rahmany HK Cattaneo CG | 2000 | Anesthesiology2000，92，5： | 1 |
| 20 | The accuracy and precision of body temperature monitoring methods during regional and general anesthesia 显示文摘 | Cattaneo CG Frank SM Hesel TW et M | 2000 | Anesthesia & Analgesia2000，90，4： | 1 |
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