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| 1 | 胰腺导管腺癌放射学报告模板:腹部放射协会和美国胰腺协会的共识声明显示文摘胰腺导管腺癌(PDA)是一种具有侵袭性、死亡率高的恶性肿瘤。在肿瘤分期时,通过影像学分析,合理判定肿瘤的范围,是患者治疗措施中最重要的步骤之一。考虑到不同医生在专业知识水平和疾病严重程度的判定有所差异,以及在放射学检查时经常缺乏相关影像学表现的完整报道,有必要采用标准化的影像学报告模板以及大家一致接受和认可的胰腺实性肿瘤术语。在腹部放射协会和美国胰腺协会的共同资助下,胰腺导管腺癌(PDA)多机构专家组(包括放射学专家、胃肠病学和肝胆胰外科学专家)共同发起了一份描述标准化报告模板的共识声明。采用这种标准化的影像学报告模板将能改进PDA患者的治疗决策过程,并可通过提供一份完整、相关、精准的疾病分期报告以优化治疗方案。通过对可行手术切除的患者恰当、一致的分期,标准化报告模板有助于促进临床和科研实验设计,从而实现在不同机构之间的实验结果的比较。 | Mahmoud M.Al-Hawary Isaac R.Francis Suresh T.Chari Elliot K.Fishman David M.Hough David S.Lu Michael Macari Alec J.Megibow Frank H.Miller Dushyant V.Sahani Diane M.Simeone 黄翔 孙灿辉 | 2014 | 影像诊断与介入放射学2014，23，4： | 52 |
| 2 | SWEET as Sugar: New Sucrose Effluxers in Plants显示文摘 | R. Frank Baker Kristen A. Leach David M. Braun | 2012 | Molecular Plant2012，5，4： | 29 |
| 3 | SPIRIT 2013声明:定义临床研究方案的标准条目显示文摘临床研究方案是临床研究设计、实行、报告和评价的基础。然而,临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》(Standard Protocol Items:Recommendations for Interventional Trials 2013 ),简称SPIRIT2013声明,一个临床研究方案必须报告的条目指引的系统建立和范围。 | An-Wen Chan Jennifer M.Tetzlaff Douglas G.Altman Andreas Laupacis Peter C.GΦtzsche Karmela Krleza-Jeri AsbjΦrn Hróbjartsson Howard Mann Kay Dickersin Jesse A.Berlin Caroline J.Doré Wendy R.Parulekar William S.M.Summerskill Trish Groves Kenneth F.Schulz Harold C.Sox Frank W.Rockhold Drummond Rennie David Moher 钟丽丹 郑颂华 吴泰相 李幼平 商洪才 张伯礼 唐旭东 吕爱平 卞兆祥 | 2013 | 中国循证医学杂志2013，13，12： | 23 |
| 4 | 报告随机对照试验的CONSORT声明修订版:说明与详述(一)显示文摘有充分的证据表明目前随机对照试验(RCT)的报告质量不尽如人意。最近的方法学调查表明,不恰当的报告及试验设计将使治疗措施的效果产生偏倚。这种系统偏差正严重损害RCT本可摒弃系统偏差的特征。RCT中的系统偏差反映出了科学性差,而科学性差会严重影响正确的伦理标准。科学家和编辑们共同制定了CONSORT(试验报告统一标准,ConsolidatedStandardsofReportingTrials,)声明以提高RCT报告质量。CONSORT声明由清单和流程图组成,作者可用来报告RCT。许多优秀期刊和重要国际性编辑组织已经采用CONSORT声明。CONSORT声明为作者提高临床试验报告质量提供指南,使得评价和解释RCT结果更方便。此文旨在增强大家对CONSORT声明的理解、应用和传播,并对每个清单项目的意义和原理进行了说明。很多项目都列出优秀报告的示例,并尽可能参考相关的经验性研究,还列出几个流程图的示例。CONSORT声明的说明和详述文件在以下网址可找到:http://www.consort-statement.org,这是提高随机对照试验报告质量的有益资源。 | Douglas G.Altman Kenneth F.Schulz David Moher Matthias Egger Frank Davidoff Diana Elbourne Peter C.Gφtzsch Thomas Lang the CONSORT Group 刘雪梅 | 2005 | 中国循证医学杂志2005，5，9： | 19 |
| 5 | The Arabidopsis DSO/ABCG 11 Transporter Affects Cutin Metabolism in Reproductive Organs and Suberin in Roots显示文摘除了它在对压力条件的保护的意义,表皮的盖子为在天线植物机关上形成的多样的表面结构的合适的开发是必要的。这层主要由一个角质矩阵组成,与表皮的蜡嵌入并且覆盖。在表皮的房间,角质和蜡跟随他们的生合成被建议被象 DSO/ABCG11 那样的 ABCG 类型 transporters 越过血浆膜出口到房间墙并且进一步到细胞外的矩阵。这里, DSO/ABCG11 功能的另外的方面被调查,主要在繁殖机关,它没在以前的报告被揭示。这被显示了相对微妙的词法、化学的显型的一根转基因的 DSO/ABCG11 silenced 线(dso-4 ) 的产生便于。这些包括的改变的花瓣和 silique 形态学,种子的熔化,和在在花和 siliques 的角质单体的层次的变化。dso-4 显型在胚胎外皮以及在发展中的种子的内乳纸巾对应于强壮的 DSO/ABCG11 基因表示。而且, DSO/ABCG11 蛋白质在胚胎 protoderm 显示了极的本地化。dso-4 异种叶子和茎的 Transcriptome 分析证明那项减少的 DSO/ABCG11 活动压制了很多联系表皮的基因的表示,暗示从血浆膜的表皮的类脂化合物的出口是在表皮新陈代谢的限制率的步。令人惊讶地, dso-4 的根软木脂作文被改变,以及二软木脂 biosynthetic 基因的根表示。一起拿,这研究在繁殖机关和根开发提供新卓见进角质和软木脂新陈代谢和他们的角色。 | David Panikashvili Jian Xin Shi Samuel Bocobza Rochus Benni Franke Lukas Schreiber Asaph Aharoni | 2010 | Molecular Plant2010，3，3： | 12 |
| 6 | How to identify which patients with asymptomatic carotid stenosis could benefit from endarterectomy or stenting显示文摘Offering routine carotid endarterectomy(CEA)or carotid artery stenting(CAS)to patients with asymptomatic carotid artery stenosis(ACS)is no longer considered as the optimal management of these patients.Equally suboptimal,however,is the policy of offering only best medical treatment(BMT)to all patients with ACS and not considering any of them for prophylactic CEA.In the last few years,there have been many studies aiming to identify reliable predictors of future cerebrovascular events that would allow the identification of patients with high-risk ACS and offer a prophylactic carotid intervention only to these patients to prevent them from becoming symptomatic.All patients with ACS should receive BMT.The present article will summarise the evidence suggesting ways to identify these high-risk asymptomatic individuals,namely:(1)microemboli detection on transcranial Doppler,(2)plaque echolucency on Duplex ultrasound,(3)progression in the severity of ACS,(4)silent embolic infarcts on brain CT/MRI,(5)reduced cerebrovascular reserve,(6)increased size of juxtaluminal hypoechoic area,(7)identification of intraplaque haemorrhage using MRI and(8)carotid ulceration.The evidence suggests that approximately 10%-15%of patents with asymptomatic stenosis might benefit from intervention;this will become more clear after publication of ongoing studies comparing stenting or endarterectomy with best medical therapy.In the meantime,no patient should be offered intervention unless there is evidence of high risk of ipsilateral stroke,from modalities such as those discussed here. | Kosmas I Paraskevas Frank J Veith J David Spence | 2018 | Stroke & Vascular Neurology2018，3，2： | 10 |
| 7 | 报告随机对照试验的CONSORT声明修订版:说明与详述(三)显示文摘 | Douglas G.Altman Kenneth F.Schulz David Moher Matthias Egger Frank Davidoff Diana Elbourne Peter C.GФtzsch Thomas Lang 刘雪梅 | 2005 | 中国循证医学杂志2005，5，11： | 8 |
| 8 | 报告随机对照试验的CONSORT声明修订版:说明与详述(二)显示文摘 | Douglas G. Altman Kenneth F. Schulz David Moher Matthias Egger Frank Davidoff Diana Elbourne Peter C. Gtzsch Thomas Lang 刘雪梅 | 2005 | 中国循证医学杂志2005，5，10： | 8 |
| 9 | Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery显示文摘Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration(GBR)and are often made of resorbable collagen or non-resorbable materials such as PTFE.While collagen membranes do not provide sufficient mechanical protection of the covered bone defect,titanium reinforced membranes and non-resorbable membranes need to be removed in a second surgery.Thus,biodegradable GBR membranes made of pure magnesium might be an alternative.In this study a biodegradable pure magnesium(99.95%)membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological perspective.After implantation,the magnesium membrane separates the regenerating bone from the overlying,faster proliferating soft tissue.During the initial healing period,the membrane maintained a barrier function and space provision,whilst retaining the positioning of the bone graft material within the defect space.As the magnesium metal corroded,it formed a salty corrosion layer and local gas cavities,both of which extended the functional lifespan of the membrane barrier capabilities.During the resorption of the magnesium metal and magnesium salts,it was observed that the membrane became surrounded and then replaced by new bone.After the membrane had completely resorbed,only healthy tissue remained.The in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen membrane.Overall,the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment. | Patrick Rider Zeljka Peric Kacarevic Akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch David Botond Hangyasi Balint Molnar Emely Bortel Bernhard Hesse Frank Witte | 2022 | Bioactive Materials2022，7，8： | 7 |
| 10 | 报告随机对照试验的CONSORT声明修订版:说明与详述(四)显示文摘Douglas G. Altman1, Kenneth F. Schulz2, David Moher3, Matthias Egger4, Frank Davidoff5, Diana Elbourne6, Peter C. Gtzsch7, Thomas Lang8 for the CONSORT | Douglas G. Altman Kenneth F. Schulz David Moher Matthias Egger Frank Davidoff Diana Elbourne Peter C. Gtzsch Thomas Lang 刘雪梅 | 2005 | 中国循证医学杂志2005，5，12： | 7 |
| 11 | 报告随机对照试验的CONSORT声明修订版:说明与详述(六)显示文摘 | Douglas G.Altman Kenneth F.Schulz David Moher Matthias Egger Frank Davidoff Diana Elbourne Peter C.Gφtzsche Thomas Lang 姚巡 | 2006 | 中国循证医学杂志2006，6，2： | 7 |
| 12 | Under the surface:Pressure-induced planetary-scale waves,volcanic lightning,and gaseous clouds caused by the submarine eruption of Hunga Tonga-Hunga Ha'apai volcano显示文摘We present a narrative of the eruptive events culminating in the cataclysmic January 15, 2022 eruption of Hunga Tonga-Hunga Ha’apai Volcano by synthesizing diverse preliminary seismic, volcanological, sound wave, and lightning data available within the first few weeks after the eruption occurred. The first hour of eruptive activity produced fast-propagating tsunami waves, long-period seismic waves, loud audible sound waves, infrasonic waves, exceptionally intense volcanic lightning and an unsteady volcanic plume that transiently reached-at 58km-the Earth’s mesosphere. Energetic seismic signals were recorded worldwide and the globally stacked seismogram showed episodic seismic events within the most intense periods of phreatoplinian activity, and they correlated well with the infrasound pressure waveform recorded in Fiji. Gravity wave signals were strong enough to be observed over the entire planet in just the first few hours, with some circling the Earth multiple times subsequently. These large-amplitude, long-wavelength atmospheric disturbances come from the Earth’s atmosphere being forced by the magmatic mixture of tephra, melt and gasses emitted by the unsteady but quasicontinuous eruption from 0402±1–1800 UTC on January 15, 2022. Atmospheric forcing lasted much longer than rupturing from large earthquakes recorded on modern instruments, producing a type of shock wave that originated from the interaction between compressed air and ambient(wavy) sea surface. This scenario differs from conventional ideas of earthquake slip, landslides, or caldera collapse-generated tsunami waves because of the enormous(~1000x) volumetric change due to the supercritical nature of volatiles associated with the hot,volatile-rich phreatoplinian plume. The time series of plume altitude can be translated to volumetric discharge and mass flow rate. For an eruption duration of ~12 h, the eruptive volume and mass are estimated at 1.9 km^(3) and~2 900 Tg, respectively, corresponding to a VEI of 5–6 for this event. The high frequency and intensity of lightning was enhanced by the production of fine ash due to magma-seawater interaction with concomitant high charge per unit mass and the high pre-eruptive concentration of dissolved volatiles. Analysis of lightning flash frequencies provides a rapid metric for plume activity and eruption magnitude. Many aspects of this eruption await further investigation by multidisciplinary teams. It represents a unique opportunity for fundamental research regarding the complex, non-linear behavior of high energetic volcanic eruptions and attendant phenomena, with critical implications for hazard mitigation, volcano forecasting, and first-response efforts in future disasters. | David A.Yuen Melissa A.Scruggs Frank J.Spera Yingcai Zheng Hao Hu Stephen R.McNutt Glenn Thompson Kyle Mandli Barry R.Keller Songqiao Shawn Wei Zhigang Peng Zili Zhou Francesco Mulargia Yuichiro Tanioka | 2022 | Earthquake Research Advances2022，2，3： | 7 |
| 13 | 报告随机对照试验的CONSORT声明修订版:说明与详述(一)显示文摘 | Douglas G. Altman Kenneth F. Schulz David Moher Matthias Egger Frank Davidoff Diana Elbourne Peter C. Gφtzsch Thomas Lang 刘雪梅 秦莉 林东涛 邓长安 李静 吴泰相 李幼平 | 2006 | 中国实用内科杂志:临床前沿版2006，26，2： | 6 |
| 14 | Camouflage Patterning in Maize Leaves Results from a Defect in Porphobilinogen Deaminase显示文摘玉米叶子从导致沿着叶的长轴穿的同种细胞的房间系的极化的房间部门被生产。我们利用了这个 stereotypical 部门模式识别形成违背同种细胞的房间系的叶绿体色素沉着部门的许多异种。这里,我们描述 camouflage1 (cf1 ) 异种,开发 nonclonal,在它的叶子的 yellowgreen 部门。我们由标注的 transposon 克隆 cf1 基因并且决定它编码 porphobilinogen 脱氨基酶(PBGD ) ,在叶绿素和 heme 早工作的酶生合成。当 PBGD 生物化学地被描绘了时,在这基因的可行变化都没在植物被报导。调查在里面 PBGD 的 vivo 功能,我们描绘了 cf1 异种。组织学的分析表明 cf1 黄扇区显示捆鞘的新奇显型房间特定的死亡。轻移动的实验决定经常的光压制了 cf1 部门形成,黑暗 / 轻的转变被要求仅仅在叶开发的一有限时间期间导致黄部门,和那种部门形式。生物化学的实验决定 cf1 异种叶子减少了 PBGD 活动和在绿、黄的区域的酶底层的增加的层次。而且, cf1 黄区域在过氧化氢酶活动显示了减小。一个阀值模型被假设向 cf1 解释上色并且合并光合的细胞区别,清除的反应的氧种,和 PBGD 功能。 | Mingshu Huanga Thomas L. Slewinski R. Frank Baker , Diane Janick-Buckner Brent Buckner Gurmukh S. Johal David M. Braun | 2009 | Molecular Plant2009，2，4： | 6 |
| 15 | 报告随机对照试验的CONSORT声明修订版:说明与详述(七)显示文摘第18条通过报告所有所做的分析,探讨各种可能影响结果的因素,包括亚组分析和校正分析,并指出哪些分析是既定的,哪些是临时增加的举例 另一个有趣的发现是,是否使用维生素A治疗与随之表现出的疾病严重程度有一定联系。使用维生素A治疗的住院患者的转归较未使用维生素A的门诊患者稍好。虽然该结果来自研究方案既定的亚组分析,但两组差异无统计学意义(α=0.05) | Douglas G.Altman Kenneth F.Schulz David Moher Matthias Egger Frank Davidoff Diana Elbourne Peter C.Gotzsche Thomas Lang 孙丁 | 2006 | 中国循证医学杂志2006，6，3： | 5 |
| 16 | RAS Is Regulated by the let-7 MicroRNA Family显示文摘 | Steven M. Johnson Helge Grosshans Jaclyn Shingara Mike Byrom Rich Jarvis Angie Cheng Emmanuel Labourier Kristy L. Reinert David Brown Frank J. Slack | 2005 | Cell2005，，5： | 5 |
| 17 | 几种典型X80管线钢管及其环焊缝性能研究显示文摘环焊缝质量是影响高钢级长输管道安全的重要因素之一。国际焊接研究中心(IWTC)针对几种典型X80管线钢的焊接开展了大量研究,测试了钢管管体和环焊缝的组织及关键力学性能,分析了X80管线钢管环焊工艺及环焊缝性能影响因素,给出了推荐工艺参数、控制措施等。采用焊接热模拟试验研究了2种不同Nb含量的X80钢管的焊接性,分析了Nb含量对焊缝区域微观组织的影响机制。结果表明,国内典型的X80管线钢管均具有良好的性能,其管体性能及焊接性满足工程需要;应采用合理的环焊工艺和质量控制措施以保证焊缝的性能;铌含量较高的X80管线钢具有更优越的焊接性,但必须严格遵从焊接工艺规范。 | David Han 齐丽华 霍春勇 José B.Bacalhau Marcos A.Stuart Nogueira Frank J.Barbaro 张永青 | 2021 | 石油管材与仪器2021，7，2： | 5 |
| 18 | The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation显示文摘 | Vidisha Tripathi Jonathan D. Ellis Zhen Shen David Y. Song Qun Pan Andrew T. Watt Susan M. Freier C. Frank Bennett Alok Sharma Paula A. Bubulya Benjamin J. Blencowe Supriya G. Prasanth Kannanganattu V. Prasanth | 2010 | Molecular Cell2010，，6： | 4 |
| 19 | 水飞蓟素的肝脏保护作用研究(英文)显示文摘目的:研究水飞蓟素对人正常肝细胞(Chang细胞株)的保护作用,尤其是其抗氧化活性和对细胞抗凋亡的保护作用。方法:采用400μmol/L H2O2处理Chang细胞20 min后,通过二氯荧光黄(dichlorofluorescein,DCF)荧光强度检测细胞内自由基水平,并检测了细胞活性及细胞内Bax表达水平和ATP水平。结果:水飞蓟素明显降低了DCF荧光信号,显示细胞内自由基生成减少。MTT实验结果显示水飞蓟素可增强细胞活性,增加细胞内ATP水平,而减少促凋亡蛋白Bax的转录和表达水平。结论:水飞蓟素可抑制Bas表达,具有保护细胞抗氧化应激所致自由基损伤的作用。水飞蓟素可作为治疗特异性肝脏疾病的有效辅助药物。 | Frank J.Burczynski 汪谷奇 David Nguyen 陈宇非 Howard J.Smith 巩跃文 | 2012 | 中南大学学报(医学版)2012，37，1： | 4 |
| 20 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
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