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| 1 | SPIRIT 2013声明:定义临床研究方案的标准条目显示文摘临床研究方案是临床研究设计、实行、报告和评价的基础。然而,临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》(Standard Protocol Items:Recommendations for Interventional Trials 2013 ),简称SPIRIT2013声明,一个临床研究方案必须报告的条目指引的系统建立和范围。 | An-Wen Chan Jennifer M.Tetzlaff Douglas G.Altman Andreas Laupacis Peter C.GΦtzsche Karmela Krleza-Jeri AsbjΦrn Hróbjartsson Howard Mann Kay Dickersin Jesse A.Berlin Caroline J.Doré Wendy R.Parulekar William S.M.Summerskill Trish Groves Kenneth F.Schulz Harold C.Sox Frank W.Rockhold Drummond Rennie David Moher 钟丽丹 郑颂华 吴泰相 李幼平 商洪才 张伯礼 唐旭东 吕爱平 卞兆祥 | 2013 | 中国循证医学杂志2013，13，12： | 23 |
| 2 | Expression of tissue factor in pancreatic adenocarcinoma is associated with activation of coagulation显示文摘瞄准:在 thromboembolism 的开发在胰腺的癌症和它的角色学习织物因素(TF ) 的表示。方法:TF 表示被北污点和间接免疫荧光在八根人的胰腺的癌房间线学习。或者拼接的 TF (asTF ) 的表示被 RT-PCR 估计。另外, TF 表示被免疫荧光与胰腺的腺癌(PCa ) 在 19 个病人的胰腺的纸巾决定,有慢性胰炎(CP ) 的 9 个病人和 20 正常控制。血浆样品(30 PCa 病人, 13 CP 病人和 20 控制) 为可溶的 TF 层次和凝结激活标记被调查[thrombin-antithrombin III 建筑群(梭织) ,凝血素碎片 1 + 2 (F1 + 2 )] 。结果:所有胰腺的癌房间线表示了 TF (8/8 ) ,他们中的大多数表示了 asTF (6/8 ) 。在蛋白质水平的 TF 表示没与癌房间线的区别相关。几乎,二件胰腺的癌症组织样品染色了为 TF (17/19 ) 积极。在 CP 的所有样品,弱染色被限制为胰腺的管房间,而一些仅仅内皮下房间在正常控制的 9/20 是积极的。TF 并且在 PCa 病人梭织层次而 2 铺平的提高的 F1 + 没与控制相比到达统计意义,显著地与控制相比被提高。在病人们梭织的 CP 和 F1 + , 2 个层次证明了显著地与控制相比被提高,尽管梭织举起少些比在 PCa 病人被读。结论:我们结束那除了起来房间膜上的 TF 的调整表示,可溶的 TF 可能在胰腺的癌症贡献凝结系统的激活。 | Stephan L Haas Ralf Jesnowski Michael Steiner Frank Hummel Jrg Ringel Christine Burstein Horst Nizze Stefan Liebe J Matthias Lhr | 2006 | World Journal of Gastroenterology2006，12，30： | 9 |
| 3 | Prospective evaluation of small bowel preparation with bisacodyl and sodium phosphate for capsule endoscopy显示文摘AIM: To determine the effect of Prepacol?, a com- bination of sodium phosphate and bisacodyl, on transit and quality of capsule endoscopy (CE). METHODS: Fivety two consecutive patients were included in this prospective study. CE was performed following a 12 h fasting period. Twenty six patients were randomized for additional preparation with Prepacol?. The quality of CE was assessed separately for the proximal and the distal small bowel by 3 experienced endoscopists on the basis of a graduation which was initially developed with 20 previous CE. RESULTS: Preparation with Prepacol? accelerated small bowel transit time (262 ± 55 min vs 287 ± 97 min), but had no effect on the quality of CE. Visibility was significantly reduced in the distal compared to the proximal small bowel. CONCLUSION: The significantly reduced visibility of CE in the distal small bowel allocates the need for a good preparation. Since Prepacol? has no beneficial effect on CE the modality of preparation and the ideal time of application remains unclear. Further standardized examinations are necessary to identify sufficient preparation procedures and to determine the impact of the volume of the preparation solution. | Andreas Franke Frank Hummel Phillip Knebel Christoph Antoni Ulrich Bcker Manfred V Singer Matthias Lhr | 2008 | World Journal of Gastroenterology2008，14，13： | 5 |
| 4 | Women's health in menopause with a fo- cus on hypertension显示文摘 | Maas AH Franke HR | 2009 | Neth Heart J2009，17，2： | 1 |
| 5 | Gonadotropin-releasing hormone agonist plus 'add-back' hormone replacement therapy for treatment of endometriosis:a prospective,randomized,placebo-controled,double-blind trial显示文摘 | Franke HR van de Weijer PH Pennings TM | | 0，，03： | 1 |
| 6 | Cystatin C:efficacy as screening test for redunced glomerular filtration rate显示文摘 | Stean HR Silke T Frank P | 2000 | Am J Nephrology2000，20，： | 1 |
| 7 | Equilibria, kinetics, and mechanism in the bicarbonate Activation of hydrogen peroxide: oxidation of sulfides by peroxymonocarbonate 显示文摘 | Richardson D E Yao HR Frank K M Bennett D A | 2000 | J Am Chem Soc2000，122，8： | 1 |
| 8 | Tibolone and low-dose continuous combined hormone treatment:vaginal bleeding pattern, efficacy and tolerability显示文摘 | Hammar ML van-de-Weijer P Franke HR | 2007 | BJOG2007，114，12： | 1 |
| 9 | Apoptosis and proliferation in breast cancer cells, cultured in vitro:effects of SERMs显示文摘 | Werner HM Franke HR Vermes I | 2005 | Climacteric2005，8，3： | 1 |
| 10 | Properties of different pancreatin preparations used in pancreatic exocrine insufficiency显示文摘 | Johannes-Matthias L?hr Frank M. Hummel Konstantinos T. Pirilis Gregor Steinkamp Andreas K?rner Friederike Henniges | 2009 | European Journal of Gastroenterology & Hepatology2009，，9： | 1 |
| 11 | Properties of different pancreatin preparations used in pancreatic exocrine insufficiency显示文摘 | Johannes-Matthias L?hr Frank M. Hummel Konstantinos T. Pirilis Gregor Steinkamp Andreas K?rner Friederike Henniges | 2009 | European Journal of Gastroenterology & Hepatology2009，，9： | 1 |
| 12 | Differential effects of progestogens on breast cancer cell lines显示文摘 | Franke HR Vermes I | 2003 | Maturitas2003，46，1： | 1 |
| 13 | Differential effects of bisphosphonates on breast cancer cell lines 显示文摘 | Verdijk R Franke HR Wolbers F | 2007 | Cancer lett2007，246，12： | 1 |
| 14 | Differential effects of progestogens on breast cancer cell lines显示文摘 | Franke HR Vermes I | 2003 | Maturitas2003，46，： | 1 |
| 15 | Gonadotropin-releasing hormone agonist plus″add-back″hormone replacement therapy for treatment of endometriosis:a prospective,randomized,placebo controlled,double-blind trial显示文摘 | Frank HR van de Weijer PH Pennings TM | 2000 | Fertil Steril2000，74，3： | 1 |
| 16 | Properties of different pancreatin preparations used in pancreatic exocrine insufficiency显示文摘 | Johannes-Matthias L?hr Frank M. Hummel Konstantinos T. Pirilis Gregor Steinkamp Andreas K?rner Friederike Henniges | 2009 | European Journal of Gastroenterology & Hepatology2009，，9： | 1 |
| 17 | Treatment of dysfunctional uterine bleeding in the perimenopause:the effects of adding combined estradiol/norethisterone acetate therapy to goserelin acetate treatment-a randomized,placebo-controlled,doubleblind trial显示文摘 | Franke HR Snaaijer FF Houben PW | 2006 | Gynecol Endocrinol2006，22，22： | 1 |
| 18 | Treatment of dysfunctional uterine bleeding in the perimenopause:the effects of adding combined estradiol/norethisterone acetate therapy to goserelin acetate treatment a randomized,placebo-controlled,double-blind trial显示文摘 | Franke HR Snaaijer FF Fbuben PW | 2006 | Gynecol Endocrinol2006，22，12： | 1 |
| 19 | Malignant peripheral nerve sheath tumor显示文摘 | Hrehorovich PA Franke HR Maximin S | 2003 | RadioGraphics2003，23，3： | 1 |
| 20 | Investigating the potential value of individual parameters of histological grading systems in a sheep model of cartilage damage: the Modified Mankin method显示文摘 | Moody HR Heard BJ Frank CB | 2012 | J Anat2012，221，1： | 1 |
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